Influence of lead on repetitive behavior and dopamine metabolism in a mouse model of iron overload

Toxicological Research

Volumn 30, Issue 4, 2014, Pages 267-276

  Chang, JuOae ^a   Kueon, Chojin ^a   Kim, Jonghan ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Autism; Hemochromatosis; HFE; Marble burying; Nestlet shredding; Selenium

Indexed keywords

MUS;

EID: 84923117696     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2014.30.4.267     Document Type: Article

References (29)

1. Toscano, C.D. and Guilarte, T.R. (2005) Lead neurotoxicity: from exposure to molecular effects. Brain Res. Rev., 49, 529-554.
2. Kim, S., Arora, M., Fernandez, C., Landero, J., Caruso, J. and Chen, A. (2013) Lead, mercury, and cadmium exposure and attention deficit hyperactivity disorder in children. Environ. Res., 126, 105-110.
3. Moreira, E.G., Vassilieff, I. and Vassilieff, V.S. (2001) Developmental lead exposure: behavioral alterations in the short and long term. Neurotoxicol. Teratol., 23, 489-495.
4. Levin, R., Grown, M.J., Kashtock, M.E., Jacobs, D.E., Whelan, E.A., Rodman, J., Schock, M.R., Padilla, A. and Sinks, T. (2008) Lead exposures in U.S. Children, 2008: implications for prevention. Environ. Health Perspect., 116, 1285-1293.
5. Hu, H., Shine, J. and Wright, R.O. (2007) The challenge posed to children's health by mixtures of toxic waste: the Tar Creek superfund site as a case-study. Pediatr. Clin. North Am., 54, 155-175.
6. Garrick, M.D., Dolan, K.G., Horbinski, C., Ghio, A.J., Higgins, D., Porubcin, M., Moore, E.G., Hainsworth, L.N., Umbreit, J.N., Conrad, M.E., Feng, L., Lis, A., Roth, J.A., Singleton, S. and Garrick, L.M. (2003) DMT1: a mammalian transporter for multiple metals. Biometals, 16, 41-54.
7. Hashmi, N.S., Kachru, D.N., Khandelwal, S. and Tandon, S.K. (1989) Interrelationship between iron deficiency and lead intoxication (Part 2). Biol. Trace Elem. Res., 22, 299-307.
8. Pietrangelo, A. (2004) Hereditary hemochromatosis-a new look at an old disease. N. Engl. J. Med., 350, 2383-2397.
9. Zhang, A., Park, S.K., Wright, R.O., Weisskopf, M.G., Mukherjee, B., Nie, H., Sparrow, D. and Hu, H. (2010) HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study. Environ. Health Perspect., 118, 1261-1266.
10. Lee, S.H., Kim, J.W., Shin, S.H., Kang, K.P., Choi, H.C., Park, K.U., Kim, H.Y., Kang, W. and Jeong, S.H. (2009) HFE gene mutations, serum ferritin level, transferrin saturation, and their clinical correlates in a Korean population. Dig. Dis. Sci., 54, 879-886.
11. Nandar, W. and Connor, J.R. (2011) HFE gene variants affect iron in the brain. J. Nutr., 141, 729S-739S.
12. Gebril, O.H. and Meguid, N.A. (2011) HFE gene polymorphisms and the risk for autism in Egyptian children and impact on the effect of oxidative stress. Dis. Markers, 31, 289-294.
13. Liu, Y., Lee, S.Y., Neely, E., Nandar, W., Moyo, M., Simmons, Z. and Connor, J.R. (2011) Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J. Biol. Chem., 286, 13161-13170.
14. Nandar, W., Neely, E.B., Unger, E. and Connor, J.R. (2013) A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice. Biochim. Biophys. Acta, 1832, 729-741.
15. Berglund, M., Lindberg, A.L., Rahman, M., Yunus, M., Grandér, M., Lönnerdal, B. and Vahter, M. (2011) Gender and age differences in mixed metal exposure and urinary excretion. Environ. Res., 111, 1271-1279.
16. Molina, R.M., Phattanarudee, S., Kim, J., Thompson, K., Wessling-Resnick, M., Maher, T.J. and Brain, J.D. (2011) Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring. Neurotoxicology, 32, 413-422.
17. Morgan, E.H. and Oates, P.S. (2002) Mechanisms and regulation of intestinal iron absorption. Blood Cells Mol. Dis., 29, 384-399.
18. Joshi, J.G. and Zimmeman, A. (1988) Ferritin: an expanded role in metabolic regulation. Toxicology, 48, 21-29.
19. Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L.A. and Paylor, R. (2009) Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety. Psychopharmacology (Berl), 204, 361-373.
20. Angoa-Pérez, M., Kane, M.J., Briggs, D.I., Francescutti, D.M. and Kuhn, D.M. (2013) Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice. J. Visualized Exp., 24, 50978.
21. Jirkof, P., Fleischmann, T., Cesarovic, N., Rettich, A., Vogel, J. and Arras, M. (2013) Assessment of postsurgical distress and pain in laboratory mice by nest complexity scoring. Lab. Anim., 47, 153-161.
22. Silveman, J.L., Yang, M., Lord, C. and Crawley, J.N. (2010) Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci., 11, 490-502.
23. Fortune, T. and Lurie, D.I. (2009) Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex. J. Comp. Neurol., 513, 542-558.
24. Pokora, M.J., Richfield, E.K. and Cory-Slechta, D.A. (1996) Preferential vulnerability of nucleus accumbens dopamine binding sites to low-level lead exposure: time course of effects and interactions with chronic dopamine agonist treatments. J. Neurochem., 67, 1540-1550.
25. Bianco, L.E., Wiesinger, J., Earley, C.J., Jones, B.C. and Beard, J.L. (2008) Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats. J. Neurochem., 106, 205-215.
26. Taylor, J.L., Rajbhandari, A.K., Berridge, K.C. and Aldridge, J.W. (2010) Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome. Brain Res., 1322, 92-101.
27. Kordas, K., Ettinger, A.S., Bellinger, D.C., Schnaas, L., Téllez Rojo, M.M., Hernández-Avila, M., Hu, H. and Wright, R.O. (2011) A dopamine receptor (DRD2) but not dopamine transporter (DAT1) gene polymorphism is associated with neurocognitive development of Mexican preschool children with lead exposure. J. Pediatr., 159, 638-643.
28. Lakshmi Priya, M.D. and Geetha, A. (2011) Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biol. Trace Elem. Res., 142, 148-158.
29. Latif, A., Heinz, P. and Cook, R. (2002) Iron deficiency in autism and Asperger syndrome. Autism, 6, 103-114.