Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Tellechea, Mariana ^a   Gianotti, Tomas Fernandéz ^a   Alvariñas, Jorge ^b   González, Claudio D ^c   Sookoian, Silvia ^a   Pirola, Carlos J ^a  

^a Department of Molecular Genetics and Biology of Complex Diseases Institute of Medical Research A Lanari IDIM University of Buenos Aires National Scientific and Technical Research Council ^*  (Argentina)

^b Policlinico Bancario   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CTC1 PROTEIN, HUMAN; STN1 PROTEIN, HUMAN; TELOMERE BINDING PROTEIN;

ADULT; BIRTH WEIGHT; FEMALE; FETUS DEVELOPMENT; GENETIC ASSOCIATION; GENETICS; HUMAN; HYPERTENSION; LEUKOCYTE; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; RADIATION RESPONSE; TELOMERE; TELOMERE HOMEOSTASIS;

ADULT; BIRTH WEIGHT; FEMALE; FETAL DEVELOPMENT; GENETIC ASSOCIATION STUDIES; HUMANS; HYPERTENSION; INFANT, NEWBORN; LEUKOCYTES; PREGNANCY; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE-BINDING PROTEINS;

EID: 84923112558     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07869     Document Type: Article

References (47)

1. Barker, D. J., Bull, A. R.,Osmond, C.&Simmonds, S. J. Fetal and placental size and risk of hypertension in adult life. BMJ 301, 259-262 (1990).
2. Curhan, G. C. et al. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 94, 3246-3250 (1996).
3. Das, U. G. & Sysyn, G. D. Abnormal fetal growth: intrauterine growth retardation, small for gestational age, large for gestational age. Pediatr. Clin. North Am. 51, 639-654 (2004).
4. Harder, T., Rodekamp, E., Schellong, K., Dudenhausen, J. W. & Plagemann, A. Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. Am. J. Epidemiol. 165, 849-857 (2007).
5. Osmond, C., Barker, D. J., Winter,P. D., Fall, C. H. & Simmonds, S. J. Early growth and death from cardiovascular disease in women. BMJ 307, 1519-1524 (1993).
6. Poston, L. Gestational weight gain: influences on the long-term health of the child. Curr. Opin. Clin. Nutr. Metab Care 15, 252-257 (2012).
7. Patel, M. S. & Srinivasan, M. Metabolic programming: causes and consequences. J. Biol. Chem. 277, 1629-1632 (2002).
8. Barker, D. J. A new model for the origins of chronic disease. Med Health Care Philos. 4, 31-35 (2001).
9. Forsen, T., Eriksson, J. G., Tuomilehto, J., Osmond, C. & Barker, D. J. Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ 319, 1403-1407 (1999).
10. Sookoian, S., Gianotti, T. F., Burgueno, A. L. & Pirola, C. J. Fetal metabolic programming and epigenetic modifications: a systems biology approach. Pediatr. Res. 73, 531-542 (2013).
11. Begum, G. et al. Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning. FASEB J. 26, 1694-1703 (2012).
12. Lillycrop, K. A. et al. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br. J. Nutr. 97, 1064-1073 (2007).
13. Burgueno, A. L., Cabrerizo, R., Gonzales, M. N., Sookoian, S. & Pirola, C. J. Maternal high-fat intake during pregnancy programs metabolic-syndromerelated phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A. J. Nutr. Biochem. 24, 6-13 (2012).
14. Engel, S. M. et al. Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort. Am. J. Epidemiol. 179, 834-842 (2014).
15. Gemma, C. et al. Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns. Obesity. (Silver. Spring) 17, 1032-1039 (2009).
16. Ruchat, S. M. et al. Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases. Epigenetics 8, 935-943 (2013).
17. Tarry-Adkins, J. L. & Ozanne, S. E. Mechanisms of early life programming: current knowledge and future directions. Am. J. Clin. Nutr. 94, 1765S-1771S (2011).
18. Entringer, S., Buss, C. &Wadhwa, P. D. Prenatal stress, telomere biology, and fetal programming of health and disease risk. Sci. Signal. 5, t12 (2012).
19. Entringer, S. et al. Maternal estriol (E) concentrations in early gestation predict infant telomere length. J. Clin. Endocrinol. Metabjc20142744 (2014).
20. Toutain, J. et al. Reduced placental telomere length during pregnancies complicated by intrauterine growth restriction. PLoS. One. 8, e54013 (2013).
21. Entringer, S. et al. Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. Am. J. Obstet. Gynecol. 208, 134-137 (2013).
22. Akkad, A. et al. Telomere length in small-for-gestational-age babies. BJOG. 113, 318-323 (2006).
23. Gemma, C. et al. Mitochondrial DNA depletion in small- and large-forgestational- age newborns. Obesity. (Silver. Spring) 14, 2193-2199 (2006).
24. Levy, D. et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc. Natl. Acad. Sci. U. S. A. 107, 9293-9298 (2010).
25. Mangino, M. et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum. Mol. Genet. 21, 5385-5394 (2012).
26. Codd, V. et al. Identification of seven loci affectingmean telomere length and their association with disease. Nat. Genet. 45, 422 (2013).
27. Burnett-Hartman, A. N. et al. Telomere-associated polymorphisms correlate with cardiovascular disease mortality in Caucasian women: the Cardiovascular Health Study. Mech. Ageing Dev. 133, 275-281 (2012).
28. Miyake, Y. et al. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to singlestranded DNA and protects telomeres independently of the Pot1 pathway. Mol. Cell 36, 193-206 (2009).
29. Wan, M., Qin, J., Songyang, Z. & Liu, D. OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J. Biol. Chem. 284, 26725-26731 (2009).
30. Anderson, B. H. et al. Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat. Genet. 44, 338-342 (2012).
31. Chen, L. Y. & Lingner, J. CST for the grand finale of telomere replication. Nucleus 4, 277-282 (2013).
32. Friedrich, U., Schwab, M., Griese, E. U., Fritz, P. & Klotz, U. Telomeres in neonates: new insights in fetal hematopoiesis. Pediatr. Res. 49, 252-256 (2001).
33. Entringer, S., Buss, C. &Wadhwa, P. D. Prenatal stress, telomere biology, and fetal programming of health and disease risk. Sci. Signal. 5, t12 (2012).
34. Cross, J. A. et al. Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes. Diabet. Med. 27, 1264-1270 (2010).
35. Fyhrquist, F. & Saijonmaa, O. Telomere length and cardiovascular aging. Ann. Med. 44 Suppl 1, S138-S142 (2012).
36. Vasan, R. S. et al. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC. Med. Genet. 8 Suppl 1, S2 (2007).
37. Maubaret, C. G. et al. Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease. PLoS. One. 8, e83122 (2013).
38. Molloy, A.M. et al.Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C- -.T variant. Am. J. Obstet. Gynecol. 186, 499-503 (2002).
39. Refsum, H., Ueland, P. M., Nygard, O. & Vollset, S. E. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49, 31-62 (1998).
40. Garfunkel, V. A. et al. Hyperhomocysteinemia but not MTHFR genotype is associated with young-onset essential hypertension. J Hum. Hypertens. 17, 361-364 (2003).
41. San, P. M., Grandi, C., Larguia, M. & Solana, C. [Standard of birth weight for gestational age in 55706 healthy newborns in a public maternity of Buenos Aires]. Medicina (B Aires) 61, 15-22 (2001).
42. Kitzmiller, J. L. et al. Diabetic pregnancy and perinatal morbidity. Am. J. Obstet. Gynecol. 131, 560-580 (1978).
43. Kawasaki, E. S. [Sample preparation from blood, cells, and other fluids]. PCR Protocols. A guide to Methods and Applications [Innis, M. A., Gelfand, D. H., Sninsky, J. J. & White, T. J. (eds.)] [146-152] (Academic Press, INC., San diego, 1990).
44. McGrath, M.,Wong, J. Y.,Michaud, D., Hunter, D. J. & De, V. I. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol. Biomarkers Prev. 16, 815-819 (2007).
45. Ramakers, C., Ruijter, J. M., Deprez, R. H. & Moorman, A. F. Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci. Lett. 339, 62-66 (2003).
46. Ehrlenbach, S. et al. Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay. Int. J. Epidemiol. 38, 1725-1734 (2009).
47. Hu, Z. et al. VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies. Nucleic Acids Res. 41, W225-31 (2013).