Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

Nature Neuroscience

Volumn 18, Issue 2, 2015, Pages 239-251

  Vogl, Annette M ^a   Brockmann, Marisa M ^a   Giusti, Sebastian A ^a   MacCarrone, Giuseppina ^a   Vercelli, Claudia A ^b   Bauder, Corinna A ^a   Richter, Julia S ^a   Roselli, Francesco ^a,c,h   Hafner, Anne Sophie ^d,e   Dedic, Nina ^a,f   Wotjak, Carsten T ^a   Vogt Weisenhorn, Daniela M ^f   Choquet, Daniel ^d,e   Turck, Christoph W ^a   Stein, Valentin ^g   Deussing, Jan M ^a   Refojo, Damian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b CONICET Partner Institute of the Max Planck Society ^*  (Argentina)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITÉ DE BORDEAUX   (France)

^e CNRS   (France)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

^g UNIVERSITY OF BONN   (Germany)

^h UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NEDD8 PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; DLGH4 PROTEIN, MOUSE; GUANYLATE KINASE; MEMBRANE PROTEIN; NEDD8 PROTEIN, MOUSE; NEDD8-ACTIVATING ENZYME E1 PROTEIN, MOUSE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC SPINE; EXCITATORY POSTSYNAPTIC POTENTIAL; FOREBRAIN; HEK293 CELL LINE; HUMAN; HUMAN CELL; MENTAL DETERIORATION; MOUSE; NEDDYLATION; NEUROTRANSMISSION; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SPINE; SYNAPSE; SYNAPTIC TRANSMISSION; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; COGNITIVE DEFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; COGNITION DISORDERS; DENDRITIC SPINES; GUANYLATE KINASE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES; SYNAPTIC TRANSMISSION; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINS;

EID: 84923095635     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3912     Document Type: Article

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