Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 5, 2015, Pages 1027-1043

  Williams, John D ^a   Torhan, Matthew C ^a   Neelagiri, Venugopal R ^a   Brown, Carson ^a   Bowlin, Nicholas O ^a   Di, Ming ^a   McCarthy, Courtney T ^a   Aiello, Daniel ^a   Peet, Norton P ^a   Bowlin, Terry L ^a   Moir, Donald T ^a  

^a MICROBIOTIX INC   (United States)

Author keywords

Mitsunobu reaction; Phenoxyacetamide; Pseudomonas aeruginosa; Type III secretion system; Virulence factor

Indexed keywords

1 METHYLINDOLE 5 YLBENZYLAMINE; 2 CHLOROPHENYLBENZYLAMINE; 2 FLUOROPHENYLBENZYLAMINE; 2 METHOXYPHENYLBENZYLAMINE; 2 METHYLPHENYLBENZYLAMINE; 2,4 DIMETHOXYPHENYLBENZYLAMINE; 3 CHLOROPHENYLBENZYLAMINE; 3 FLUOROPHENYLBENZYLAMINE; 3 METHOXYPHENYLBENZYLAMINE; 3 METHYLPHENYLBENZYLAMINE; 3,4 DIMETHOXYPHENYLBENZYLAMINE; 3,4 METHYLENEDIOXYPHENYLBENZYLAMINE; 4 CHLOROPHENYLBENZYLAMINE; 4 FLUOROPHENYLBENZYLAMINE; 4 METHOXYPHENYLBENZYLAMINE; 4 METHYLPHENYLBENZYLAMINE; ACETAMIDE DERIVATIVE; ANTIBIOTIC AGENT; BENZIMIDAZOLE 5 YLBENZYLAMINE; BENZOFURAN 5 YLBENZYLAMINE; BENZOTHIOPHENE 5 YLBENZYLAMINE; INDOLE 2 YLBENZYLAMINE; INDOLE 4 YLBENZYLAMINE; INDOLE 5 YLBENZYLAMINE; INDOLE 6 YLBENZYLAMINE; PHENOXYACETAMIDE; PHENOXYACETAMIDE INHIBITOR DERIVATIVE; PHENYLBENZYLAMINE; PYRROLO[2,3 B]PYRIDIN 5 YLBENZYLAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ACETIC ACID DERIVATIVE; AMIDE; ANTIINFECTIVE AGENT; PHENOXYACETIC ACID;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HIGH THROUGHPUT SCREENING; IC50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; TYPE III SECRETION SYSTEM; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; HAMSTER; METABOLISM;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

ACETATES; AMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84923090939     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.01.011     Document Type: Article

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