Increased protein oxidation and decreased expression of nuclear factor E2-related factor 2 protein in skin tissue of patients with diabetes

Clinical and Experimental Dermatology

Volumn 40, Issue 2, 2015, Pages 192-200

  Lee, Y J ^a   Kwon, S B ^a   An, J M ^a   Kim, C H ^a   Lee, S H ^a   Choi, C Y ^a   Nam, D H ^a   Park, J W ^a   Nam, H S ^a   Lee, M W ^b   Cho, Moon Kyun ^a  

^a Soonchunhyang University College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; DINITROPHENYLHYDRAZONE; EOSIN; HEMATOXYLIN; MESSENGER RNA; PHENYLHYDRAZONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; OXIDATIVE STRESS; OXYBLOTTING ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; WESTERN BLOTTING; CASE CONTROL STUDY; METABOLISM; PHYSIOLOGY;

ADULT; AGED; BLOTTING, WESTERN; CASE-CONTROL STUDIES; DIABETES MELLITUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SKIN;

EID: 84923081724     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/ced.12487     Document Type: Article

References (25)

1. Izakovic J. [Skin manifestations of diabetes mellitus]. Praxis (Bern 1994) 2002; 91: 1011-18.
2. Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab 2000; 26: 163-76.
3. Chen XF, Lin WD, Lu SL, Xie T, Ge K, Shi YQ, et al. Mechanistic study of endogenous skin lesions in diabetic rats. Exp Dermatol 2010; 19: 1088-95.
4. Itoh K, Ishii T, Wakabayashi N, Yamamoto M. Regulatory mechanisms of cellular response to oxidative stress. Free Radic Res 1999; 31: 319-24.
5. Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007; 47: 89-116.
6. Lee YJ, Jeong HY, Kim YB, et al. Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. Food Chem Toxicol 2012; 50: 116-23.
7. Chan K, Han XD, Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 2001; 98: 4611-16.
8. Xue M, Qian Q, Adaikalakoteswari A, et al. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes 2008; 57: 2809-17.
9. Wolff SP, Dean RT. Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes. Biochem J 1987; 245: 243-50.
10. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-20.
11. Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med 1991; 10: 339-52.
12. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40: 405-12.
13. West IC. Radicals and oxidative stress in diabetes. Diabet Med 2000; 17: 171-80.
14. Chan K, Kan YW. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci USA 1999; 96: 12731-6.
15. Ma Q. Xenobiotic-activated receptors: from transcription to drug metabolism to disease. Chem Res Toxicol 2008; 21: 1651-71.
16. Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 2006; 38: 769-89.
17. Kobayashi A, Kang MI, Okawa H, et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 2004; 24: 7130-9.
18. Dinkova-Kostova AT, Holtzclaw WD, Cole RN, et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 2002; 99: 11908-13.
19. Cheng X, Siow RC, Mann GE. Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxid Redox Signal 2011; 14: 469-87.
20. Ning JL, Mo LW, Lai XN. Low- and high-dose hydrogen peroxide regulation of transcription factor NF-E2-related factor 2. Chin Med J (Engl) 2010; 123: 1063-9.
21. Moi P, Chan K, Asunis I, et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 1994; 91: 9926-30.
22. Papaiahgari S, Kleeberger SR, Cho HY, et al. NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. J Biol Chem 2004; 279: 42302-12.
23. Macara IG. Transport into and out of the nucleus. Microbiol Mol Biol Rev 2001; 65: 570-94.
24. Watt RA, Shatzman AR, Rosenberg M. Expression and characterization of the human c-myc DNA-binding protein. Mol Cell Biol 1985; 5: 448-56.
25. Chan JY, Han XL, Kan YW. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci USA 1993; 90: 11371-5.