SIRT3 protects endothelial cells from high glucose-induced cytotoxicity

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 1, 2015, Pages 353-360

  Liu, Guodong ^a   Cao, Mingming ^a   Xu, Ying ^a   Li, Yanbo ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes; Endothelial cell dysfunction; High glucose; SIRT3

Indexed keywords

GLUCOSE; SIRT3 PROTEIN, HUMAN; SIRTUIN 3;

CELL SURVIVAL; DIABETES MELLITUS; DRUG EFFECTS; ENDOTHELIUM CELL; HUMAN; IMMUNOBLOTTING; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUNEL ASSAY; UMBILICAL VEIN;

CELL SURVIVAL; DIABETES MELLITUS; ENDOTHELIAL CELLS; GLUCOSE; HUMANS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; SIRTUIN 3; UMBILICAL VEINS;

EID: 84923077289     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E and Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003; 52: 2795-2804.
2. Morgan CL, Currie CJ, Stott NC, Smithers M, Butler CC and Peters JR. The prevalence of multiple diabetes-related complications. Dia-bet Med 2000; 17: 146-151.
3. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 2005; 28: 1769-1778.
4. Kojda G and Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res 1999; 43: 562-571.
5. Ungvari Z, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson K, de Cabo R and Csiszar A. Adaptive induction of NF-E2-related factor-2-driven antioxidant gen-es in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol 2011; 300: H1133-1140.
6. Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F and Em-anueli C. Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation 2011; 123: 282-291.
7. Inoue T, Hiratsuka M, Osaki M and Oshimura M. The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 2007; 6: 1011-1018.
8. Bell EL and Guarente L. The SirT3 divining rod points to oxidative stress. Mol Cell 2011; 42: 561-568.
9. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR and Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010; 464: 121-125.
10. Xie Z, Zhang J, Wu J, Viollet B and Zou MH. Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes. Diabetes 2008; 57: 3222-3230.
11. Bonanno G, Mariotti A, Procoli A, Corallo M, Scambia G, Pierelli L and Rutella S. Inter-leukin-21 induces the differentiation of human umbilical cord blood CD34-lineage-cells into pseudomature lytic NK cells. BMC immunology 2009; 10: 46.
12. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L and Moore MAS. Expression of VEGFR-2 and AC-133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 2000; 95: 952-958.
13. Cosentino F, Hishikawa K, Katusic ZS and Lüscher TF. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 1997; 96: 25-28.
14. Wolff SP, Jiang ZY and Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med 1991; 10: 339-352.
15. Fernie AR, Carrari F and Sweetlove LJ. Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport. Curr Opin Plant Biol 2004; 7: 254-261.
16. Qiu X, Brown K, Hirschey MD, Verdin E and Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662-667.
17. Loomans CJ, de Koning EJ, Staal FJ, Rook-maaker MB, Verseyden C, de Boer HC, Verhaar MC, Braam B, Rabelink TJ and van Zonneveld AJ. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004; 53: 195-199.
18. Geary K, Knaub LA, Schauer IE, Keller AC, Wa-tson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ and Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans 2014; 42: 231-238.
19. Haigis MC and Guarente LP. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006; 20: 2913-2921.
20. Schumacker PT. SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF. Cancer Cell 2011; 19: 299-300.
21. Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX and Gius D. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010; 17: 41-52.
22. Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Ya-qoob MM, Holness MJ and Sugden MC. Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia 2013; 56: 1068-1077.
23. Zeng H, He X, Hou X, Li L and Chen JX. Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. Am J Physiol Heart Circ Physiol 2014; 306: H585-597.
24. Johansen JS, Harris AK, Rychly DJ and Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 2005; 4: 5.
25. Zelko IN, Mariani TJ and Folz RJ. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 2002; 33: 337-49.