The antileukemia activity of natural product HQ17(3) is possibly associated with downregulation of MIR-17-92 cluster

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Liao, Ya Chun ^a   Lin, Tzu Heng ^a   Chen, Chih Ying ^b   Lin, Shwu Bin ^c   Au, Lo Chun ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

10',13',15' HEPTADECATRIENYLHYDROQUINONE; ANTILEUKEMIC AGENT; DICER; FLUOROURACIL; MICRORNA; MICRORNA 17 92; MYC PROTEIN; NATURAL PRODUCT; UNCLASSIFIED DRUG; 2-(10-HEPTADECENYL)-1,4-HYDROQUINONE; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; HYDROQUINONE DERIVATIVE; MIRN17-92 MICRORNA, HUMAN; MYC PROTEIN, HUMAN; TUMOR ANTIGEN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; K562 CELL LINE; LEUKEMIA CELL; ONCOGENE C MYC; U937 CELL LINE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTIGENS, NEOPLASM; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; FLUOROURACIL; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; HYDROQUINONES; LEUKEMIA; MICRORNAS; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 84923076982     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/306718     Document Type: Article

References (21)

1. P.-L. Wu, S.-B. Lin, C.-P. Huang, and R. Y.-Y. Chiou, "Antioxidative and cytotoxic compounds extracted from the sap of Rhus succedanea, " Journal of Natural Products, vol. 65, no. 11, pp. 1719-1721, 2002.
2. T. Y. Lin, C. P. Huang, L. C. Au, Y. W. Chang, C. Y. Hu, and S. B. Lin, "A cysteine-reactive alkyl hydroquinone modifies topoisomerase IIα, enhances DNA breakage, and induces apoptosis in cancer cells, " Chemical Research in Toxicology, vol. 25, no. 11, pp. 2340-2351, 2012.
3. C. Huang, W. Fang, L. Lin et al., "Anticancer activityofbotanical alkyl hydroquinones attributed to topoisomerase II poisoning Toxicology and Applied Pharmacology, vol. 227, no. 3, pp. 331-338, 2008.
4. K. M. Nishida and M. C. Siomi, "Molecular mechanisms of RNA silencing by siRNA, miRNA and piRNA, " Tanpakushitsu Kakusan Koso, vol. 51, supplement 16, pp. 2450-2455, 2006.
5. M. Ghildiyal and P. D. Zamore, "Small silencing RNAs: An expanding universe, " Nature Reviews Genetics, vol. 10, no. 2, pp. 94-108, 2009.
6. X. H. Sheng and L. X. Du, "Progress on the research of microRNAs and its function in humans and animals, " Yi Chuan, vol. 29, no. 6, pp. 651-658, 2007.
7. W. Wu, M. Sun, G. Zou, and J. Chen, "MicroRNA and cancer: current status and prospective, " International Journal of Cancer, vol. 120, no. 5, pp. 953-960, 2007.
8. J. W. Vardiman, N. L. Harris, and R. D. Brunning, "The World Health Organization (WHO) classification of the myeloid neoplasms, " Blood, vol. 100, no. 7, pp. 2292-2302, 2002.
9. V. Olive, I. Jiang, and L. He, "Mir-17-92, a cluster of miRNAs in the midst of the cancer network, " International Journal of Biochemistry and Cell Biology, vol. 42, no. 8, pp. 1348-1354, 2010.
10. Z. Zhang, Y. An, and C. Teng, "The roles of miR-17-92 cluster in mammal development and tumorigenesis, " Yi Chuan, vol. 31, no. 11, pp. 1094-1100, 2009.
11. M. Dews, A. Homayouni, D. Yu et al., "Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster, " Nature Genetics, vol. 38, no. 9, pp. 1060-1065, 2006.
12. K. A. ODonnell, E. A. Wentzel, K. I. Zeller, C. V. Dang, and J. T. Mendell, "c-Myc-regulated microRNAs modulate E2F1 expression, " Nature, vol. 435, no. 7043, pp. 839-843, 2005.
13. L. Venturini, K. Battmer, M. Castoldi et al., "Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells, " Blood, vol. 109, no. 10, pp. 4399-4405, 2007.
14. L. Hong, M. Lai, M. Chen et al., "The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogeneinduced senescence, " Cancer Research, vol. 70, no. 21, pp. 8547-8557, 2010.
15. N. Cloonan, M. K. Brown, A. L. Steptoe et al., "The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition, " Genome Biology, vol. 9, no. 8, article R127, 2008.
16. V. Olive, M. J. Bennett, J. C. Walker et al., "miR-19 is a key oncogenic component of mir-17-92, "Genes andDevelopment, vol. 23, no. 24, pp. 2839-2849, 2009.
17. Y. Cao, S. L. Yu, Y. Wang, G. Y. Guo, Q. Ding, and R. H. An, "MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24, " Tumor Biology, vol. 32, no. 1, pp. 179-188, 2011.
18. J. Tao, D. Wu, P. Li, B. Xu, Q. Lu, and W. Zhang, "microRNA-18a, amember of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells, " Molecular Medicine Reports, vol. 5, no. 1, pp. 167-172, 2012.
19. Z. Luo, Y. Dai, L. zhang et al., "miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma, " Carcinogenesis, vol. 34, no. 2, pp. 415-425, 2013.
20. Y. R. Chen, Y. C. Robin, T. Y. Lin et al., "Identification of an alkylhydroquinone from rhus succedanea as an inhibitor of tyrosinase andmelanogenesis, " Journal of Agricultural and Food Chemistry, vol. 57, no. 6, pp. 2200-2205, 2009.
21. G. K. Geiss, R. E. Bumgarner, and B. Birditt, "Directmultiplexed measurement of gene expression with color-coded probe pairs, " Nature Biotechnology, vol. 26, no. 3, pp. 317-325, 2008.