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Volumn 23, Issue 5, 2015, Pages 985-995
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Computer-aided discovery of aminopyridines as novel JAK2 inhibitors
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Author keywords
Aminopyridine; JAK2 inhibitor; Shape based drug design; Structure based drug design; V shape; Virtual screening
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Indexed keywords
2 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YL) 5 (TOLUENE 2 SULFONYLAMINO)NICOTINIC ACID;
2 (BUTYLMETHYLAMINO) 5 5 (TOLUENE 2 SULFONYLAMINO)NICOTINIC ACID;
2 DIETHYLAMINO 5 5 (TOLUENE 2 SULFONYLAMINO)NICOTINIC ACID;
2 MORPHOLIN 4 YL 5 (TOLUENE 2 SULFONYLAMINO)NICOTINIC ACID;
5' (2 NITROBENZENESULFONYLAMINO) 3,4,5,6 TETRAHYDRO 2H[1,2']BIPYRIDINYL 4,3' DICARBOXYLIC ACID 4 ETHYL ESTER;
5' (4 TRIFLUOROMETHYLBENZENESULFONYLAMINO) 3,4,5,6 TETRAHYDRO 2H[1,2']BIPYRIDINYL 4,3' DICARBOXYLIC ACID 4 ETHYL ESTER;
5' (TOLUENE 2 SULFONYLAMINO) 3,4,5,6 TETRAHYDRO 2H[1,2']BIPYRIDINYL 3'CARBOXYLIC ACID;
5' (TOLUENE 2 SULFONYLAMINO) 3,4,5,6 TETRAHYDRO 2H[1,2']BIPYRIDINYL 4,3' DICARBOXYLIC ACID 4 ETHYL ESTER;
6 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YL) N (3 METHOXYPHENYL) 5 NITRONICOTINAMIDE;
6 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YL) N (4 METHELPYRIDIN 2 YL) 5 NITRONICOTINAMIDE;
6 (3,4 DIHYDRO 1H ISOQUINOLIN 2 YL) N (6 METHELPYRIDIN 2 YL) 5 NITRONICOTINAMIDE;
6 (BENZYLETHYLAMINO) N (6 METHYLPYRIDIN 2 YL) 5 NITRO NICOTINAMIDE;
6' (3 METHOXYPHENYLCARBAMOYL) 2' NITRO 3,4,5,6 TETRAHYDRO 2H [1,3']BIPYRIDINYL 4 CARBOXYLIC ACID ETHYL ESTE;
ADENOSINE TRIPHOSPHATE;
AMINOPYRIDINE DERIVATIVE;
ETHYL 1 [5 [(3 METHOXYPHENYL)CARBAMOYL]3 NITROPYRIDIN 2 YL]PIPERIDINE 4 CARBOXYLATE;
JANUS KINASE 2;
JANUS KINASE 2 INHIBITOR;
N (3 METHOXYPHENYL) 5 NITRO 6 (4 PYRIMIDIN 2 YL PIPERAZIN 1 YL)NICOTINAMIDE;
N (3 METHOXYPHENYL) 6 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] 5 NITRONICOTINAMIDE;
UNCLASSIFIED DRUG;
JAK2 PROTEIN, HUMAN;
PROTEIN KINASE INHIBITOR;
ARTICLE;
BINDING AFFINITY;
BINDING SITE;
COMPUTER AIDED DESIGN;
COMPUTER PROGRAM;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG MECHANISM;
DRUG POTENCY;
DRUG PROTEIN BINDING;
DRUG SCREENING;
DRUG STRUCTURE;
ENZYME ACTIVITY;
ENZYME BINDING;
ENZYME INHIBITION;
IN VITRO STUDY;
MOLECULAR DOCKING;
PROCESS OPTIMIZATION;
STRUCTURE ACTIVITY RELATION;
ANTAGONISTS AND INHIBITORS;
CHEMISTRY;
DRUG DEVELOPMENT;
HT 29 CELL LINE;
HUMAN;
IC50;
RUMEX;
AMINOPYRIDINES;
COMPUTER-AIDED DESIGN;
DRUG DISCOVERY;
DRUG EVALUATION, PRECLINICAL;
HT29 CELLS;
HUMANS;
INHIBITORY CONCENTRATION 50;
JANUS KINASE 2;
PROTEIN KINASE INHIBITORS;
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EID: 84923072206
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.01.016 Document Type: Article |
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Times cited : (10)
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References (30)
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