Broussonetia kazinoki modulates the expression of VEGFR-2 and MMP-2 through the inhibition of ERK, Akt and p70S6K-dependent signaling pathways: Its implication in endothelial cell proliferation, migration and tubular formation

Oncology Reports

Volumn 32, Issue 4, 2014, Pages 1531-1536

  Cho, Young Rak ^a,b   Kim, Jae Hyeon ^a   Kim, Jin Kyu ^b   Ahn, Eun Kyung ^b   Ko, Hye Jin ^b   In, Jae Kyung ^a   Lee, Sang Jin ^c   Bae, Gyu Un ^c   Kim, Yong Ke ^c   Oh, Joa Sub ^a,b   Seo, Dong Wan ^a  

^a Dankook University   (South Korea)

^b Gyeonggi Institute of Science and Technology Promotion   (South Korea)

^c Sookmyung Women's University   (South Korea)

Author keywords

Angiogenesis; Broussonetia kazinoki; Matrix metalloproteinases 2; Vascular endothelial growth factor receptor 2

Indexed keywords

ANGIOGENESIS INHIBITOR; BROUSSONETIA KAZINOKI EXTRACT; CYCLIN DEPENDENT KINASE; CYCLINE; GELATINASE A; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; MMP2 PROTEIN, HUMAN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; BROUSSONETIA KAZINOKI; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; BROUSSONETIA; CELL MOTION; DRUG EFFECTS; METABOLISM; NEOVASCULARIZATION (PATHOLOGY);

BROUSSONETIA; CELL MOVEMENT; CELL PROLIFERATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84923068459     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3380     Document Type: Article

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