The in vitro antitumor activity of Siegesbeckia glabrescens against ovarian cancer through suppression of receptor tyrosine kinase expression and the signaling pathways

Oncology Reports

Volumn 30, Issue 1, 2013, Pages 221-226

  Cho, Young Rak ^a   Choi, Shin Wook ^b   Seo, Dong Wan ^a  

^a Dankook University   (South Korea)

^b Radiant Research Institute   (South Korea)

Author keywords

Invasion; Migration; Ovarian cancer; Proliferation; Receptor tyrosine kinases; Siegesbeckia glabrescens

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; PLANT EXTRACT; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; S6 KINASE; SIEGESBECKIA GLABRESCENS EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL ADHESION; CELL CYCLE PROGRESSION; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MECHANICS; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIEGESBECKIA GLABRESCENS; SIGNAL TRANSDUCTION; TRADITIONAL MEDICINE;

ASTERACEAE; CADHERINS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FOCAL ADHESION KINASE 1; HUMANS; MEDICINE, KOREAN TRADITIONAL; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; PHOSPHORYLATION; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RETINOBLASTOMA PROTEIN; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84878187208     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2468     Document Type: Article

References (33)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
2. Lemmon MA and Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell 141: 1117-1134, 2010.
3. Hynes NE and Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354, 2005. (Pubitemid 40637826)
4. Alper Ö, Bergmann-Leitner ES, Bennett TA, Hacker NF, Stromberg K and Stetler-Stevenson WG: Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells. J Natl Cancer Inst 93: 1375-1384, 2001. (Pubitemid 32936814)
5. van der Bilt ARM, de Vries EGE, de Jong S, Timmer-Bosscha H, van der Zee AGJ and Reyners AKL: Turning promise into progress for antiangiogenic agents in epithelial ovarian cancer. Crit Rev Oncol Hematol 84: 224-242, 2012.
6. Masoumi Moghaddam S, Amini A, Morris D and Pourgholami M: Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer. Cancer Metastasis Rev 31: 143-162, 2012.
7. Cole C, Lau S, Backen A, et al: Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer. Cancer Biol Ther 10: 495-504, 2010.
8. Gui T and Shen K: The epidermal growth factor receptor as a therapeutic target in epithelial ovarian cancer. Cancer Epidemiol 36: 490-496, 2012.
9. Tiwari N, Gheldof A, Tatari M and Christofori G: EMT as the ultimate survival mechanism of cancer cells. Semin Cancer Biol 22: 194-207, 2012.
10. Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
11. Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006. (Pubitemid 43278296)
12. Lee JM, Dedhar S, Kalluri R and Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172: 973-981, 2006.
13. Bourboulia D and Stetler-Stevenson WG: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 20: 161-168, 2010.
14. Kang BK, Lee EH and Kim HM: Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro. J Ethnopharmacol 57: 73-79, 1997. (Pubitemid 27344796)
15. Kim H-M, Lee J-H, Won J-H, et al: Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens. Phytother Res 15: 572-576, 2001. (Pubitemid 33021860)
16. Kim JY, Lim HJ and Ryu J-H: In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. Bioorg Med Chem Lett 18: 1511-1514, 2008. (Pubitemid 351226516)
17. Li H, Kim JY, Hyeon J, Lee HJ and Ryu J-H: In vitro antiinflammatory activity of a new Sesquiterpene lactone isolated from Siegesbeckia glabrescens. Phytother Res 25: 1323-1327, 2011.
18. Jun SY, Choi YH and Shin HM: Siegesbeckia glabrescens induces apoptosis with different pathways in human MCF-7 and MDA-MB-231 breast carcinoma cells. Oncol Rep 15: 1461-1467, 2006.
19. Cho Y-R, Kim SH, Ko HY, Kim M-D, Choi SW and Seo D-W: Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep 26: 861-867, 2011.
20. Seo D-W, Saxinger WC, Guedez L, Cantelmo AR, Albini A and Stetler-Stevenson WG: An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivo. Peptides 32: 1840-1848, 2011.
21. Kim SH, Cho Y-R, Kim H-J, et al: Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway. Blood 120: 4892-4902, 2012.
22. Yoon HJ, Cho Y-R, Joo J-H and Seo D-W: Knockdown of integrin α3β1 expression induces proliferation and migration of non-small cell lung cancer cells. Oncol Rep 29: 662-668, 2013.
23. Kim SH, Cho Y-R, Kim M-D, Kim HJ, Choi SW and Seo D-W: Inhibitory effects of sepiapterin on vascular endothelial growth factor-A-induced proliferation and adhesion in human umbilical vein endothelial cells. Arch Pharm Res 34: 1571-1577, 2011.
24. Cho Y-R, Choi S and Seo D-W: Sepiapterin regulates cell proliferation and migration: its association with integrin α3β1 and p53 in human lung cancer cells. Genes Genom 33: 577-582, 2011.
25. Bourboulia D, Jensen-Taubman S, Rittler MR, et al: Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment. Am J Pathol 179: 2589-2600, 2011.
26. Hong SY, Cho JY and Seo D-W: Ginsenoside Rp1 inhibits proliferation and migration of human lung cancer cells. Biomol Ther 19: 411-418, 2011.
27. Malumbres M and Barbacid M: Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9: 153-166, 2009.
28. Mitra SK, Hanson DA and Schlaepfer DD: Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68, 2005. (Pubitemid 40064899)
29. Desgrosellier JS and Cheresh DA: Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10: 9-22, 2010.
30. Slack-Davis JK, Atkins KA, Harrer C, Hershey ED and Conaway M: Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. Cancer Res 69: 1469-1476, 2009.
31. Eliceiri BP: Integrin and growth factor receptor crosstalk. Circ Res 89: 1104-1110, 2001.
32. Hannigan GE, McDonald PC, Walsh MP and Dedhar S: Integrin-linked kinase: Not so 'pseudo' after all. Oncogene 30: 4375-4385, 2011.
33. Lu Y-M, Rong M-L, Shang C, et al: Suppression of HER-2 via siRNA interference promotes apoptosis and decreases metastatic potential of SKOV-3 human ovarian carcinoma cells. Oncol Rep 29: 1133-1139, 2013.