miR-449a and CDK6 in gastric carcinoma

Oncology Letters

Volumn 8, Issue 4, 2014, Pages 1533-1538

  Li, Li Ping ^a   Wu, Wei Jing ^b   Sun, Da Yong ^a   Xie, Zi Ying ^a   Ma, Yan Chun ^a   Zhao, Ya Gang ^a  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cyclin dependent kinase 6 protein; Gastric carcinoma; MGC 803; microRNA 449; Real time cell analysis

Indexed keywords

4', 6 DIAMIDINO 2 PHENYLINDOLE; CYCLIN DEPENDENT KINASE 6; MICRORNA; MICRORNA 449A; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; APOPTOSIS; ARTICLE; CELL MIGRATION ASSAY; CELL SCRATCH TEST; CONTROLLED STUDY; CORRELATION COEFFICIENT; DOWN REGULATION; GASTRIC CANCER CELL LINE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; METASTASIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; STOMACH CARCINOMA; TUMOR GROWTH; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING;

EID: 84923068271     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2370     Document Type: Article

References (19)

1. Smith MG, Hold GL, Tahara E, et al: Cellular and molecular aspects of gastric cancer. World J Gastroenterol 12: 2979-2990, 2006.
2. Jemal A, Bray F, Center MM, et al: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
3. Stenvang J, Petri A, Lindow M, et al: Inhibition of microRNA function by antimiR oligonucleotides. Silence 3: 1, 2012.
4. Wu WK, Lee CW, Cho CH, et al: MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene 29: 5761-5771, 2010.
5. Lizé M, Klimke A and Dobbelstein M: MicroRNA-449 in cell fate determination. Cell Cycle 10: 2874-2882, 2011.
6. Teng Z, Kuang X, Wang J and Zhang X: Real-time cell analysis-a new method for dynamic, quantitative measurement of infectious viruses and antiserum neutralizing activity. J Virol Methods 193: 364-370, 2013.
7. Bou Kheir T, Futoma-Kazmierczak E, Jacobsen A, et al: miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer 10: 29, 2011.
8. Chan SH, Wu CW, Li AF, et al: miR-21 microRNA expression in human gastric carcinomas and its clinical association. Anticancer Res. 28: 907-911, 2008
9. Tsujiura M, Ichikawa D, Komatsu S, et al: Circulating microRNAs in plasma of patients with gastric cancers. Br J Cancer 102: 1174-1179, 2010.
10. Duman-Scheel M, Weng L, Xin S and Du W: Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417: 299-304, 2002.
11. Kozar K and Sicinski P: Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes. Cell Cycle 4: 388-391, 2005.
12. Laman H, Funes JM, Ye H, et al: Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. EMBO J 24: 3104-3116, 2005.
13. Cam EJ, Liu BD, Bjeldanes LF and Firestone GL: Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. J Biol Chem 276: 22332-22340, 2001.
14. Yang XJ, Feng M, Jiang X, et al: miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 23: 2388-2393, 2009.
15. Feng M and Yu Q: miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit. Cell Cycle 9: 213-214, 2010.
16. Lizé M, Herr C, Klimke A, et al: MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia. Cell Cycle 9: 4579-4583, 2010.
17. Bhatia S, Kaul D and Varma N: Functional genomics of tumor suppressor miR-196b in T-cell acute lymphoblastic leukemia. Mol Cell Biochem 346: 103-116, 2011.
18. Guan Y, Mizoguchi M, Yoshimoto K, et al: MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance. Clin Cancer Res 16: 4289-4297, 2010.
19. Katsios C, Baltogiannis G and Roukos DH: Progress, challenges and new genome-based concepts in the multidisciplinary treatment of gastric cancer. Expert Rev Anticancer Ther 11: 503-506, 2011.