The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway

Journal of Neuroscience

Volumn 35, Issue 7, 2015, Pages 3190-3200

  Pucilowska, Joanna ^a   Vithayathil, Joseph ^a   Tavares, Emmanuel J ^a   Kelly, Caitlin ^a   Colleen Karlo, J ^a   Landreth, Gary E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autism; Cortex; Cortical development; ERK; MAP kinases; Mouse models

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; AUTISM; BODY WEIGHT; BRAIN CORTEX; BRAIN WEIGHT; CELL CYCLE ARREST; CELL PROLIFERATION; CHROMOSOME DELETION; CONTROLLED STUDY; CYTOARCHITECTURE; DISEASE MODEL; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MAZE TEST; MEMORY DISORDER; MOUSE; NERVE PROJECTION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; WESTERN BLOTTING; AGE; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; CHROMOSOME 16; COMPLICATION; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MEMORY DISORDERS; METABOLISM; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL;

AGE FACTORS; ANIMALS; ANXIETY; AUTISTIC DISORDER; CELL PROLIFERATION; CEREBRAL CORTEX; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 16; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EXPLORATORY BEHAVIOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; ORGAN SIZE; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84923040471     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4864-13.2015     Document Type: Article

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