Parkinson’s Disease and Sleep/Wake Disturbances

Current Neurology and Neuroscience Reports

Volumn 15, Issue 3, 2015, Pages

  Suzuki, Keisuke ^a   Miyamoto, Masayuki ^a   Miyamoto, Tomoyuki ^a   Hirata, Koichi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Excessive daytime sleepiness; Insomnia; Parkinson s disease; Rapid eye movement sleep behavior disorder; Restless legs syndrome; Sleep apnea syndrome

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

COMORBIDITY; DAYTIME SOMNOLENCE; DISEASE ASSOCIATION; DISEASE COURSE; EPWORTH SLEEPINESS SCALE; HUMAN; NARCOLEPSY; PARASOMNIA; PARKINSON DISEASE; PARKINSONISM; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; POSITRON EMISSION TOMOGRAPHY; REM SLEEP; RESTLESS LEGS SYNDROME; REVIEW; SLEEP DISORDER; SLEEP DISORDERED BREATHING; UNIFIED PARKINSON DISEASE RATING SCALE; SLEEP DISORDERS;

COMORBIDITY; HUMANS; PARKINSON DISEASE; SLEEP DISORDERS;

EID: 84923033508     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-015-0525-5     Document Type: Review

References (118)

1. Avidan A, Hays RD, Diaz N, Bordelon Y, Thompson AW, Vassar SD, et al. Associations of sleep disturbance symptoms with health-related quality of life in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2013;25(4):319–26. doi:10.1176/appi.neuropsych.12070175.
2. Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Coleman SY, Brooks DJ, et al. Health-related quality of life in early Parkinson's disease: the impact of nonmotor symptoms. Mov Disord. 2014;29(2):195–202. doi:10.1002/mds.25664. This study demonstrated a significant impact of non-motor symptoms, such as insomnia, depression, anxiety and memory disturbance, in 158 patients with newly diagnosed PD.
3. Lees AJ, Blackburn NA, Campbell VL. The nighttime problems of Parkinson's disease. Clin Neuropharmacol. 1988;11(6):512–9.
4. Sixel-Döring F, Schweitzer M, Mollenhauer B, Trenkwalder C. Intraindividual variability of REM sleep behavior disorder in Parkinson's disease: a comparative assessment using a new REM sleep behavior disorder severity scale (RBDSS) for clinical routine. J Clin Sleep Med. 2011;7(1):75–80.
5. Kumar S, Bhatia M, Behari M. Sleep disorders in Parkinson's disease. Mov Disord. 2002;17(4):775–81. doi:10.1002/mds.10167.
6. Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson's disease. Mov Disord. 1998;13(6):895–9. doi:10.1002/mds.870130606.
7. Neikrug AB, Maglione JE, Liu L, Natarajan L, Avanzino JA, Corey-Bloom J, et al. Effects of sleep disorders on the non-motor symptoms of Parkinson disease. J Clin Sleep Med. 2013;9(11):1119–29. doi:10.5664/jcsm.3148.
8. Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, et al. REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease. J Neurol Neurosurg Psychiatry. 2014;85(5):560–6. doi:10.1136/jnnp-2013-306104.
9. Chaudhuri KR, Prieto-Jurcynska C, Naidu Y, Mitra T, Frades-Payo B, Tluk S, et al. The nondeclaration of nonmotor symptoms of Parkinson's disease to health care professionals: an international study using the nonmotor symptoms questionnaire. Mov Disord. 2010;25(6):704–9. doi:10.1002/mds.22868.
10. van Gilst MM, Bloem BR, Overeem S. "Sleep benefit" in Parkinson's disease: a systematic review. Parkinsonism Relat Disord. 2013;19(7):654–9. doi:10.1016/j.parkreldis.2013.03.014.
11. Suzuki K, Miyamoto T, Miyamoto M, Numao A, Sakuta H, Fujita H et al. Sleep Disturbances in Patients with Parkinson’s Disease, A Synopsis of Parkinson's Disease, Dr. Abdul Qayyum Rana (Ed.), ISBN: 978-953-51-1229-7, InTech, 2014. doi:10.5772/57320.
12. Diederich NJ, McIntyre DJ. Sleep disorders in Parkinson's disease: many causes, few therapeutic options. J Neurol Sci. 2012;314(1–2):12–9. doi:10.1016/j.jns.2011.10.025.
13. Diederich NJ, Comella CL. Sleep disturbances in Parkinson’s disease. In: Chokroverty S, Hening WA, Walters AS, editors. Sleep and movement disorders. Philadelphia: Elsevier Science; 2003. p. 478–88.
14. Trotti LM, Bliwise DL. Treatment of the sleep disorders associated with Parkinson's disease. Neurotherapeutics: J Am Soc Exp NeuroTher. 2014;11(1):68–77. doi:10.1007/s13311-013-0236-z.
15. Peeraully T, Yong MH, Chokroverty S, Tan EK. Sleep and Parkinson's disease: a review of case–control polysomnography studies. Mov Disord. 2012;27(14):1729–37. doi:10.1002/mds.25197. Peeraully et al. provided a review result of case–control polysomnographic studies, which found a higher prevalence of RBD in PD patients than controls; however, the incidence of obstructive sleep apnea did not differ between controls and PD patients. Subjective sleepiness was greater in PD patients than controls, but objective sleepiness, measured using multiple sleep latency tests, did not increase in PD patients.
16. Chaudhuri KR, Pal S, DiMarco A, Whately-Smith C, Bridgman K, Mathew R, et al. The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2002;73(6):629–35.
17. Suzuki K, Okuma Y, Hattori N, Kamei S, Yoshii F, Utsumi H, et al. Characteristics of sleep disturbances in Japanese patients with Parkinson's disease. A study using Parkinson's disease sleep scale. Mov Disord. 2007;22(9):1245–51. doi:10.1002/mds.21257.
18. Dhawan V, Dhoat S, Williams AJ, Dimarco A, Pal S, Forbes A, et al. The range and nature of sleep dysfunction in untreated Parkinson's disease (PD). A comparative controlled clinical study using the Parkinson's disease sleep scale and selective polysomnography. J Neurol Sci. 2006;248(1–2):158–62. doi:10.1016/j.jns.2006.05.004.
19. Buskova J, Klempir J, Majerova V, Picmausova J, Sonka K, Jech R, et al. Sleep disturbances in untreated Parkinson's disease. J Neurol. 2011. doi:10.1007/s00415-011-6109-7.
20. Högl B, Arnulf I, Comella C, Ferreira J, Iranzo A, Tilley B, et al. Scales to assess sleep impairment in Parkinson's disease: critique and recommendations. Mov Disord. 2011;25(16):2704–16. doi:10.1002/mds.23190.
21. Trenkwalder C, Kohnen R, Hӧgl B, Metta V, Sixel-Doring F, Frauscher B, et al. Parkinson's disease sleep scale-validation of the revised version PDSS-2. Mov Disord. 2011;26(4):644–52. doi:10.1002/mds.23476. Trenkwalder et al. developed the revised version of the PD sleep scale, the PDSS-2, which is the bedside screening tool for sleep problems related to PD. Applying the PDSS-2 may be useful for detecting and managing PD-related nocturnal symptoms.
22. Suzuki K, Miyamoto M, Miyamoto T, Tatsumoto M, Watanabe Y, Suzuki S, et al. Nocturnal disturbances and restlessness in Parkinson's disease: using the Japanese version of the Parkinson's disease sleep scale-2. J Neurol Sci. 2012;318(1–2):76–81. doi:10.1016/j.jns.2012.03.022.
23. Trenkwalder C, Kies B, Rudzinska M, Fine J, Nikl J, Honczarenko K, et al. Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double-blind, randomized, placebo-controlled study (RECOVER). Mov Disord. 2011;26(1):90–9. doi:10.1002/mds.23441.
24. Ondo WG, Dat Vuong K, Khan H, Atassi F, Kwak C, Jankovic J. Daytime sleepiness and other sleep disorders in Parkinson's disease. Neurology. 2001;57(8):1392–6.
25. Suzuki K, Miyamoto T, Miyamoto M, Okuma Y, Hattori N, Kamei S, et al. Excessive daytime sleepiness and sleep episodes in Japanese patients with Parkinson's disease. J Neurol Sci. 2008;271(1–2):47–52. doi:10.1016/j.jns.2008.03.008.
26. Tandberg E, Larsen JP, Karlsen K. Excessive daytime sleepiness and sleep benefit in Parkinson's disease: a community-based study. Mov Disord. 1999;14(6):922–7.
27. Tan EK, Lum SY, Fook-Chong SM, Teoh ML, Yih Y, Tan L, et al. Evaluation of somnolence in Parkinson's disease: comparison with age- and sex-matched controls. Neurology. 2002;58(3):465–8.
28. Rissling I, Frauscher B, Kronenberg F, Tafti M, Stiasny-Kolster K, Robyr AC, et al. Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. Sleep. 2006;29(1):108–11.
29. Fronczek R, Overeem S, Lee SY, Hegeman IM, van Pelt J, van Duinen SG, et al. Hypocretin (orexin) loss in Parkinson's disease. Brain. 2007;130(Pt 6):1577–85. doi:10.1093/brain/awm090.
30. Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson's disease. Brain. 2007;130(Pt 6):1586–95. doi:10.1093/brain/awm097.
31. Overeem S, Scammell TE, Lammers GJ. Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy. Curr Opin Neurol. 2002;15(6):739–45. doi:10.1097/01.wco.0000044800.53746.5a.
32. Yasui K, Inoue Y, Kanbayashi T, Nomura T, Kusumi M, Nakashima K. CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. J Neurol Sci. 2006;250(1–2):120–3. doi:10.1016/j.jns.2006.08.004.
33. Compta Y, Santamaria J, Ratti L, Tolosa E, Iranzo A, Munoz E, et al. Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia. Brain. 2009;132(Pt 12):3308–17. doi:10.1093/brain/awp263.
34. Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP. Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology. 2006;67(5):853–8. doi:10.1212/01.wnl.0000233980.25978.9d.
35. Kaynak D, Kiziltan G, Kaynak H, Benbir G, Uysal O. Sleep and sleepiness in patients with Parkinson's disease before and after dopaminergic treatment. Eur J Neurol. 2005;12(3):199–207. doi:10.1111/j.1468-1331.2004.00971.x.
36. Cochen De Cock V, Bayard S, Jaussent I, Charif M, Grini M, Langenier MC, et al. Daytime sleepiness in Parkinson's disease: a reappraisal. PLoS One. 2014;9(9):e107278. doi:10.1371/journal.pone.0107278.
37. Arnulf I, Leu-Semenescu S. Sleepiness in Parkinson's disease. Parkinsonism Relat Disord. 2009;15 Suppl 3:S101–4. doi:10.1016/S1353-8020(09)70792-8.
38. Arnulf I, Konofal E, Merino-Andreu M, Houeto JL, Mesnage V, Welter ML, et al. Parkinson's disease and sleepiness: an integral part of PD. Neurology. 2002;58(7):1019–24.
39. Bliwise DL, Trotti LM, Wilson AG, Greer SA, Wood-Siverio C, Juncos JJ, et al. Daytime alertness in Parkinson's disease: potentially dose-dependent, divergent effects by drug class. Mov Disord. 2012. doi:10.1002/mds.25082.
40. Chaudhuri KR, Logishetty K. Dopamine receptor agonists and sleep disturbances in Parkinson's disease. Parkinsonism Relat Disord. 2009;15 Suppl 4:S101–4. doi:10.1016/S1353-8020(09)70845-4.
41. Hobson DE, Lang AE, Martin WR, Razmy A, Rivest J, Fleming J. Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group. JAMA. 2002;287(4):455–63.
42. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep. 1986;9(2):293–308.
43. Arnulf I. REM sleep behavior disorder: motor manifestations and pathophysiology. Mov Disord. 2012;27(6):677–89. doi:10.1002/mds.24957.
44. Ohayon MM, Caulet M, Priest RG. Violent behavior during sleep. J Clin Psychiatry. 1997;58(8):369–76. quiz 77.
45. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38 % of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology. 1996;46(2):388–93.
46. Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81 % of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744–8. doi:10.1016/j.sleep.2012.10.009.
47. Iranzo A, Tolosa E, Gelpi E, Molinuevo JL, Valldeoriola F, Serradell M, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12(5):443–53. doi:10.1016/S1474-4422(13)70056-5.
48. Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology. 2009;72(15):1296–300. doi:10.1212/01.wnl.0000340980.19702.6e.
49. Iranzo A, Fernandez-Arcos A, Tolosa E, Serradell M, Molinuevo JL, Valldeoriola F, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One. 2014;9(2):e89741. doi:10.1371/journal.pone.0089741.
50. Boeve BF, Silber MH, Ferman TJ, Lin SC, Benarroch EE, Schmeichel AM, et al. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med. 2013;14(8):754–62. doi:10.1016/j.sleep.2012.10.015. Although a significant link between RBD and synucleinopathies has been reported in several longitudinal studies, this clinicopathological study confirmed a high percentage of pathologically proven synucleinopathies (94 %) among RBD patients associated with neurodegenerative diseases (n = 170).
51. Murray ME, Ferman TJ, Boeve BF, Przybelski SA, Lesnick TG, Liesinger AM, et al. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Neurology. 2013;81(19):1681–9. doi:10.1212/01.wnl.0000435299.57153.f0. This study used pathologically confirmed DLB patients and found that the presence of RBD was associated with a higher likelihood of DLB pathology and less severe AD-related pathology.
52. Dauvilliers Y, Postuma RB, Ferini-Strambi L, Arnulf I, Högl B, Manni R, et al. Family history of idiopathic REM behavior disorder: a multicenter case–control study. Neurology. 2013;80(24):2233–5. doi:10.1212/WNL.0b013e318296e967.
53. Frauscher B, Jennum P, Ju YE, Postuma RB, Arnulf I, Cochen De Cock V, et al. Comorbidity and medication in REM sleep behavior disorder: a multicenter case–control study. Neurology. 2014;82(12):1076–9. doi:10.1212/WNL.0000000000000247.
54. Postuma RB, Montplaisir JY, Pelletier A, Dauvilliers Y, Oertel W, Iranzo A, et al. Environmental risk factors for REM sleep behavior disorder: a multicenter case–control study. Neurology. 2012;79(5):428–34. doi:10.1212/WNL.0b013e31825dd383.
55. Boeve BF. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15–54. doi:10.1111/j.1749-6632.2009.05115.x.
56. American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014.
57. American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep and Associated Events: rules, terminology and technical specifications: version 2.0.3. Darien, IL, USA; 2014.
58. Miyamoto T, Miyamoto M, Iwanami M, Kobayashi M, Nakamura M, Inoue Y, et al. The REM sleep behavior disorder screening questionnaire: validation study of a Japanese version. Sleep Med. 2009;10(10):1151–4. doi:10.1016/j.sleep.2009.05.007.
59. Stiasny-Kolster K, Mayer G, Schafer S, Moller JC, Heinzel-Gutenbrunner M, Oertel WH. The REM sleep behavior disorder screening questionnaire—a new diagnostic instrument. Mov Disord. 2007;22(16):2386–93. doi:10.1002/mds.21740.
60. Boeve BF, Molano JR, Ferman TJ, Smith GE, Lin SC, Bieniek K, et al. Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep Med. 2011;12(5):445–53. doi:10.1016/j.sleep.2010.12.009.
61. Li SX, Wing YK, Lam SP, Zhang J, Yu MW, Ho CK, et al. Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK). Sleep Med. 2010;11(1):43–8. doi:10.1016/j.sleep.2009.06.008.
62. Frauscher B, Ehrmann L, Zamarian L, Auer F, Mitterling T, Gabelia D, et al. Validation of the Innsbruck REM sleep behavior disorder inventory. Mov Disord. 2012;27(13):1673–8. doi:10.1002/mds.25223.
63. Iranzo A, Santamaria J. Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorder. Sleep. 2005;28(2):203–6.
64. Postuma RB, Gagnon JF, Vendette M, Montplaisir JY. Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease. Brain. 2009;132(Pt 12):3298–307. doi:10.1093/brain/awp244.
65. Gagnon JF, Bertrand JA, Genier Marchand D. Cognition in rapid eye movement sleep behavior disorder. Front Neurol. 2012;3:82. doi:10.3389/fneur.2012.00082.
66. Postuma RB, Lanfranchi PA, Blais H, Gagnon JF, Montplaisir JY. Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Mov Disord. 2010;25(14):2304–10. doi:10.1002/mds.23347.
67. Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology. 2006;67(12):2236–8. doi:10.1212/01.wnl.0000249313.25627.2e.
68. Iwanami M, Miyamoto T, Miyamoto M, Hirata K, Takada E. Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. Sleep Med. 2010;11(4):361–5. doi:10.1016/j.sleep.2009.12.006.
69. Postuma RB, Gagnon JF, Rompre S, Montplaisir JY. Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. Neurology. 2010;74(3):239–44. doi:10.1212/WNL.0b013e3181ca0166.
70. Miyamoto T, Orimo S, Miyamoto M, Hirata K, Adachi T, Hattori R, et al. Follow-up PET studies in case of idiopathic REM sleep behavior disorder. Sleep Med. 2010;11(1):100–1. doi:10.1016/j.sleep.2009.05.006.
71. Iranzo A, Lomena F, Stockner H, Valldeoriola F, Vilaseca I, Salamero M, et al. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. Lancet Neurol. 2010;9(11):1070–7. doi:10.1016/S1474-4422(10)70216-7.
72. Postuma RB, Lang AE, Gagnon JF, Pelletier A, Montplaisir JY. How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain. 2012;135(Pt 6):1860–70. doi:10.1093/brain/aws093.
73. McDade EM, Boot BP, Christianson TJ, Pankratz VS, Boeve BF, Ferman TJ, et al. Subtle gait changes in patients with REM sleep behavior disorder. Mov Disord. 2013;28(13):1847–53. doi:10.1002/mds.25653.
74. Trenkwalder C, Arnulf I. Principles and practice of sleep medicine. In: Kryger MH, Roth T, Dement WC, editors. Parkinsonism. 5th ed. St. Louis: Saunders; 2010. p. 980–92.
75. Bugalho P, Viana-Baptista M. REM sleep behavior disorder and motor dysfunction in Parkinson's disease—a longitudinal study. Parkinsonism Relat Disord. 2013;19(12):1084–7. doi:10.1016/j.parkreldis.2013.07.017.
76. Bolitho SJ, Naismith SL, Terpening Z, Grunstein RR, Melehan K, Yee BJ, et al. Investigating rapid eye movement sleep without atonia in Parkinson's disease using the rapid eye movement sleep behavior disorder screening questionnaire. Mov Disord. 2014;29(6):736–42. doi:10.1002/mds.25832.
77. Kim YE, Jeon BS. Clinical implication of REM sleep behavior disorder in Parkinson's disease. J Parkinson's Dis. 2014;4(2):237–44. doi:10.3233/JPD-130293.
78. Gong Y, Xiong KP, Mao CJ, Shen Y, Hu WD, Huang JY, et al. Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Med. 2014;15(6):647–53. doi:10.1016/j.sleep.2013.12.021.
79. Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, et al. REM sleep behavior disorder in Japanese patients with Parkinson's disease: a multicenter study using the REM sleep behavior disorder screening questionnaire. J Neurol. 2012;259(8):1606–12. doi:10.1007/s00415-011-6386-1.
80. Postuma RB, Gagnon JF, Vendette M, Charland K, Montplaisir J. Manifestations of Parkinson disease differ in association with REM sleep behavior disorder. Mov Disord. 2008;23(12):1665–72. doi:10.1002/mds.22099.
81. Postuma RB, Gagnon JF, Vendette M, Charland K, Montplaisir J. REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features. J Neurol Neurosurg Psychiatry. 2008;79(10):1117–21. doi:10.1136/jnnp.2008.149195.
82. Sixel-Döring F, Trautmann E, Mollenhauer B, Trenkwalder C. Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology. 2011;77(11):1048–54. doi:10.1212/WNL.0b013e31822e560e.
83. Suzuki K, Miyamoto T, Miyamoto M, Watanabe Y, Suzuki S, Tatsumoto M, et al. Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson's disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire. BMC Neurol. 2013;13:18. doi:10.1186/1471-2377-13-18.
84. Gagnon JF, Vendette M, Postuma RB, Desjardins C, Massicotte-Marquez J, Panisset M, et al. Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease. Ann Neurol. 2009;66(1):39–47. doi:10.1002/ana.21680.
85. Erro R, Santangelo G, Picillo M, Vitale C, Amboni M, Longo K, et al. Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients. J Neurol. 2012;259(9):1808–13. doi:10.1007/s00415-011-6407-0.
86. Plomhause L, Dujardin K, Duhamel A, Delliaux M, Derambure P, Defebvre L, et al. Rapid eye movement sleep behavior disorder in treatment-naive Parkinson disease patients. Sleep Med. 2013;14(10):1035–7. doi:10.1016/j.sleep.2013.04.018.
87. Postuma RB, Bertrand JA, Montplaisir J, Desjardins C, Vendette M, Rios Romenets S, et al. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: a prospective study. Mov Disord. 2012;27(6):720–6. doi:10.1002/mds.24939.
88. Miyamoto T, Miyamoto M, Iwanami M, Hirata K. Cardiac 123I-MIBG accumulation in Parkinson's disease differs in association with REM sleep behavior disorder. Parkinsonism Relat Disord. 2011;17(3):219–20. doi:10.1016/j.parkreldis.2010.11.020.
89. Nomura T, Inoue Y, Högl B, Uemura Y, Kitayama M, Abe T, et al. Relationship between (123)I-MIBG scintigrams and REM sleep behavior disorder in Parkinson's disease. Parkinsonism Relat Disord. 2010;16(10):683–5. doi:10.1016/j.parkreldis.2010.08.011.
90. Mahale R, Yadav R, Pal PK. Rapid eye movement sleep behaviour disorder in young- and older-onset Parkinson disease: a questionnaire-based study. Sleep Med. 2014;15(6):642–6. doi:10.1016/j.sleep.2014.01.022.
91. Neikrug AB, Avanzino JA, Liu L, Maglione JE, Natarajan L, Corey-Bloom J, et al. Parkinson's disease and REM sleep behavior disorder result in increased non-motor symptoms. Sleep Med. 2014. doi:10.1016/j.sleep.2014.04.009.
92. Garcia-Lorenzo D, Longo-Dos Santos C, Ewenczyk C, Leu-Semenescu S, Gallea C, Quattrocchi G, et al. The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease. Brain. 2013;136(Pt 7):2120–9. doi:10.1093/brain/awt152.
93. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101–19.
94. Schmidauer C, Sojer M, Seppi K, Stockner H, Högl B, Biedermann B, et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann Neurol. 2005;58(4):630–4. doi:10.1002/ana.20572.
95. Wong JC, Li Y, Schwarzschild MA, Ascherio A, Gao X. Restless legs syndrome: an early clinical feature of Parkinson disease in men. Sleep. 2014;37(2):369–72. doi:10.5665/sleep.3416.
96. Nomura T, Inoue Y, Miyake M, Yasui K, Nakashima K. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson's disease. Mov Disord. 2006;21(3):380–4. doi:10.1002/mds.20734.
97. Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol. 2002;59(3):421–4.
98. Peralta CM, Frauscher B, Seppi K, Wolf E, Wenning GK, Högl B, et al. Restless legs syndrome in Parkinson's disease. Mov Disord. 2009;24(14):2076–80. doi:10.1002/mds.22694.
99. Iranzo A, Comella CL, Santamaria J, Oertel W. Restless legs syndrome in Parkinson's disease and other neurodegenerative diseases of the central nervous system. Mov Disord. 2007;22 Suppl 18:S424–30. doi:10.1002/mds.21600.
100. Ondo WG. Sleep/wake problems in Parkinson's disease: pathophysiology and clinicopathologic correlations. J Neural Transm. 2014. doi:10.1007/s00702-014-1239-6.
101. Möller JC, Unger M, Stiasny-Kolster K, Oertel WH. Restless legs syndrome (RLS) and Parkinson's disease (PD)-related disorders or different entities? J Neurol Sci. 2010;289(1–2):135–7. doi:10.1016/j.jns.2009.08.035.
102. Braga-Neto P, da Silva-Junior FP, Sueli Monte F, de Bruin PF, de Bruin VM. Snoring and excessive daytime sleepiness in Parkinson's disease. J Neurol Sci. 2004;217(1):41–5.
103. Lee JE, Shin HW, Kim KS, Sohn YH. Factors contributing to the development of restless legs syndrome in patients with Parkinson disease. Mov Disord. 2009;24(4):579–82. doi:10.1002/mds.22410.
104. Krishnan PR, Bhatia M, Behari M. Restless legs syndrome in Parkinson's disease: a case-controlled study. Mov Disord. 2003;18(2):181–5. doi:10.1002/mds.10307.
105. Angelini M, Negrotti A, Marchesi E, Bonavina G, Calzetti S. A study of the prevalence of restless legs syndrome in previously untreated Parkinson's disease patients: absence of co-morbid association. J Neurol Sci. 2011;310(1–2):286–8. doi:10.1016/j.jns.2011.08.012.
106. Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology. 2011;77(22):1941–6. doi:10.1212/WNL.0b013e31823a0cc8.
107. Shin HY, Youn J, Yoon WT, Kim JS, Cho JW. Restless legs syndrome in Korean patients with drug-naive Parkinson's disease: a nation-wide study. Parkinsonism Relat Disord. 2013;19(3):355–8. doi:10.1016/j.parkreldis.2012.09.009.
108. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–5. doi:10.1056/NEJM199304293281704.
109. Suzuki K, Miyamoto M, Miyamoto T, Suzuki S, Watanabe Y, Numao A, et al. Snoring is associated with an impaired motor function, disease severity and the quality of life but not with excessive daytime sleepiness in patients with Parkinson's disease. Intern Med. 2013;52(8):863–9.
110. da Silva Jr FP, Prado GF, Barbosa ER, Tufik S, Togeiro SM. Sleep disordered breathing in Parkinson's disease: a critical appraisal. Sleep Med Rev. 2014;18(2):173–8. doi:10.1016/j.smrv.2013.04.005.
111. De Cock VC, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M, et al. Is obstructive sleep apnea a problem in Parkinson's disease? Sleep Med. 2010;11(3):247–52. doi:10.1016/j.sleep.2009.05.008.
112. Trotti LM, Bliwise DL. No increased risk of obstructive sleep apnea in Parkinson's disease. Mov Disord. 2010;25(13):2246–9. doi:10.1002/mds.23231.
113. Diederich NJ, Vaillant M, Leischen M, Mancuso G, Golinval S, Nati R, et al. Sleep apnea syndrome in Parkinson's disease. A case–control study in 49 patients. Mov Disord. 2005;20(11):1413–8. doi:10.1002/mds.20624.
114. Maria B, Sophia S, Michalis M, Charalampos L, Andreas P, John ME, et al. Sleep breathing disorders in patients with idiopathic Parkinson's disease. Respir Med. 2003;97(10):1151–7.
115. Nomura T, Inoue Y, Kobayashi M, Namba K, Nakashima K. Characteristics of obstructive sleep apnea in patients with Parkinson's disease. J Neurol Sci. 2013;327(1–2):22–4. doi:10.1016/j.jns.2013.01.036.
116. Valko PO, Hauser S, Werth E, Waldvogel D, Baumann CR. Heart rate variability in patients with idiopathic Parkinson's disease with and without obstructive sleep apnea syndrome. Parkinsonism Relat Disord. 2012;18(5):525–31. doi:10.1016/j.parkreldis.2012.01.023.
117. Yong MH, Fook-Chong S, Pavanni R, Lim LL, Tan EK. Case control polysomnographic studies of sleep disorders in Parkinson's disease. PLoS One. 2011;6(7):e22511. doi:10.1371/journal.pone.0022511.
118. Neikrug AB, Liu L, Avanzino JA, Maglione JE, Natarajan L, Bradley L, et al. Continuous positive airway pressure improves sleep and daytime sleepiness in patients with Parkinson disease and sleep apnea. Sleep. 2014;37(1):177–85. doi:10.5665/sleep.3332.