Restless Legs Syndrome (RLS) and Parkinson's disease (PD)-Related disorders or different entities?

Journal of the Neurological Sciences

Volumn 289, Issue 1-2, 2010, Pages 135-137

  Möller, Jens Carsten ^a   Unger, Marcus ^a   Stiasny Kolster, Karin ^a   Oertel, Wolfgang Hermann ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Comorbidity; Diagnostic criteria; Parkinson's disease; Restless Legs Syndrome; Validation

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; FERRITIN; LEVODOPA; METOCLOPRAMIDE; MIRTAZAPINE; NEUROLEPTIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRANSFERRIN;

ARTICLE; CHROMOSOME 15; CHROMOSOME 2; CHROMOSOME 6; DISEASE ASSOCIATION; FERRITIN BLOOD LEVEL; GATE CONTROL THEORY; GENETICS; HUMAN; NOCICEPTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; PROTEIN AGGREGATION; PUTAMEN; RESTLESS LEGS SYNDROME; SUBSTANTIA NIGRA; TRANSFERRIN BLOOD LEVEL;

HUMANS; PARKINSON DISEASE; RESTLESS LEGS SYNDROME;

EID: 74149085981     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.08.035     Document Type: Article

References (32)

1. Allen R.P., Barker P.B., Wehrl F., Song H.K., and Earley C.J. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56 (2001) 263-265
2. Allen R.P., Picchietti D., Hening W.A., Trenkwalder C., Walters A.S., and Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology work shop at the National Institute of Health. Sleep Med 4 (2003) 101-119
3. Braak H., and del Tredici K. Nervous system pathology in sporadic Parkinson's disease. Neurology 70 (2008) 1916-1925
4. Braga-Neto P., da Silva-Junior F.P., Sueli Monte F., de Bruin P.F.C., and de Bruin V.M.S. Snoring and excessive daytime sleepiness in Parkinson's disease. J Neurol Sci 217 (2004) 41-45
5. Connor J.R., Boyer P.J., Menzies S.L., Dellinger B., Allen R.P., Ondo W.G., et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 61 (2003) 304-309
6. Earley C.J., Connor J.R., Beard J.L., Malecki E.A., Epstein D.K., and Allen R.P. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 54 (2000) 1698-1700
7. Eisensehr I., Wetter T.C., Linke R., Noachtar S., von Lindeiner H., Gildehaus F.J., et al. Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome. Neurology 57 (2001) 1307-1309
8. Garcia-Borreguero D., Egatz R., Winkelmann J., and Berger K. Epidemiology of restless legs syndrome: the current status. Sleep Med Rev 10 (2006) 153-167
9. Gasser T. Update on the genetics of Parkinson's disease. Mov Disord 22 (2007) S343-S350
10. Godau J., Schweitzer K.J., Liepelt I., Gerloff C., and Berg D. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. Mov Disord 22 (2007) 187-192
11. Gomez-Esteban J.C., Zarranz J.J., Tijero B., Velasco F., Barcena J., Rouco I., et al. Restless legs syndrome in Parkinson's disease. Mov Disord 22 (2007) 1912-1916
12. Hening W., Walters A.S., Allen R.P., Montplaisir J., Myers A., and Ferini-Strambi L. Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med 5 (2004) 237-246
13. Hughes A.J., Daniel S.E., Kilford L., and Lees A.J. Accuracy of clinical diagnosis of Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55 (1992) 181-184
14. Iranzo I., Comella C.L., Santamaria J., and Oertel W. Restless legs syndrome in Parkinson's disease and other neurodegenerative diseases of the central nervous system. Mov Disord 22 (2007) S424-S430
15. Krishnan P.R., Bhatia M., and Behari M. Restless legs syndrome in Parkinson's disease: a case-controlled study. Mov Disord 18 (2003) 181-185
16. Lang A.E., and Johnson K. Akathisia in Parkinson's disease. Neurology 37 (1987) 477-481
17. Lee J.E., Shin H.W., Kim K.S., and Sohn Y.H. Factors contributing to the development of restless legs syndrome in patients with Parkinson's disease. Mov Disord 24 4 (2009) 579-582
18. Loo H.V., and Tan E.K. Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease. J Neurol Sci 266 (2008) 145-149
19. Mylius V., Engau I., Teepker M., Stiasny-Kolster K., Schepelmann K., Oertel W.H., et al. Pain sensitivity and descending inhibition in Parkinson's disease. J Neurol Neurosurg Psychiatry 80 (2009) 24-28
20. Nomura T., Inoue Y., Miyake M., Yasui K., and Nakashima K. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson's syndrome. Mov Disord 21 (2006) 380-384
21. O'Keeffe S.T., Gavin K., and Lavan J.N. Iron status and restless legs syndrome in the elderly. Age Ageing 23 (1994) 200-203
22. Oertel W.H., Benes H., Garcia-Borreguero D., Geisler P., Högl B., Saletu B., et al. Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe. Sleep Med 9 (2008) 228-239
23. Oertel W.H., Trenkwalder C., Zucconi M., Benes H., Garcia Borreguero D.G., Bassetti C., et al. State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndrome. Mov Disord 22 (2007) S466-S475
24. Ondo W.G., Vuong K.D., and Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 59 3 (2002) 421-424
25. Schmidauer C., Sojer M., Seppi K., Stockner H., Högl B., Biedermann B., et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann Neurol 58 (2005) 630-634
26. Schormair B., Kemlink D., Roeske D., Eckstein G., Xiong L., Lichtner P., et al. PTPRD (protein tyrosine phosphatase receptor delta) is associated with restless legs syndrome. Nat Genet 40 (2008) 946-948
27. Stiasny-Kolster K., Kohnen R., Möller J.C., Trenkwalder C., and Oertel W.H. Validation of the "L-DOPA test" for diagnosis of restless legs syndrome. Mov Disord 21 (2006) 1333-1339
28. Stiasny-Kolster K., Magerl W., Oertel W.H., Möller J.C., and Treede R.D. Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome. Brain 127 (2004) 773-782
29. Sun E.R., Chen C.A., Ho G., Earley C.J., and Allen R.P. Iron and the restless legs syndrome. Sleep 21 (1998) 371-377
30. Tan E.K., Lum S.Y., and Wong M.C. Restless legs syndrome in Parkinson's disease. J Neurol Sci 196 (2002) 33-36
31. Winkelmann J., Lichtner P., Schormair B., Uhr M., Hauk S., Stiasny-Kolster K., et al. Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. Mov Disord 23 (2008) 350-358
32. Winkelmann J., Schormair B., Lichtner P., Ripke S., Xiong L., Jalilzadeh S., et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 39 (2007) 1000-1006