SIRT2 is involved in the modulation of depressive behaviors

Scientific Reports

Volumn 5, Issue , 2015, Pages 8415-

  Liu, Rui ^a   Dang, Wei ^b   Du, Ying ^a   Zhou, Qiong ^a   Jiao, Kai ^a   Liu, Zhaohui ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b SHANDONG MENTAL HEALTH CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANILIDE; SIRTUIN 2; TENOVIN-D3; THIOUREA;

ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; DEPRESSION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HIPPOCAMPUS; MALE; MENTAL STRESS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PHENOTYPE; RAT;

ANILIDES; ANIMALS; BEHAVIOR, ANIMAL; DEPRESSION; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HIPPOCAMPUS; MALE; NEUROGENESIS; PHENOTYPE; RATS; SIRTUIN 2; STRESS, PSYCHOLOGICAL; THIOUREA;

EID: 84923022358     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08415     Document Type: Article

References (28)

1. Miller, A. H.,Maletic, V.&Raison, C. L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiat. 65, 732-741 (2009).
2. Roiser, J. P., Elliott, R. & Sahakian, B. J. Cognitive mechanisms of treatment in depression. Neuropsychopharmacol. 37, 117-136 (2011).
3. Whittle, J. R. et al . Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation. Trends. Endocrin. Met. 18 356-364 (2007).
4. Han, H. Potential role of sirtuin as a therapeutic target for neurodegenerative diseases. J. Clin. Neurol. 5, 120-125 (2009).
5. Paraíso, A. F., Mendes, K. L. & Santos, S. H. S. Brain Activation of SIRT1: Role in Neuropathology. Mol. Neurobiol. 48, 1-9 (2013).
6. Gao, J. et al. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Natur. 466, 1105-1109 (2010).
7. Michán, S. et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 30, 9695-9707 (2010).
8. Donmez, G. & Outeiro, T. F. SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO. Mol. Med. 5, 344-352(2013).
9. Abe, N. et al. Altered sirtuin deacetylase gene expression in patients with a mood disorder. J. Psychiatr. Res. 45, 1106-1112 (2011).
10. Sahay, A.,Drew,M. R.&Hen, R. Dentate gyrus neurogenesis and depression. Prog Brain. Res. 163, 697-822 (2007).
11. Garza, J. C., Guo, M., Zhang, W. & Lu, X. Y. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3b /b-catenin signaling. Mol. Psychiatr. 17, 790-808 (2011).
12. Egan, R. J. et al . Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. Behav. Brain. Res. 205, 38-44 (2009).
13. Covington, H. E. et al. Antidepressant actions of histone deacetylase inhibitors. J. Neurosci. 29, 11451-11460 (2009).
14. Schroeder, F. A. et al. A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests. PloS one 8, e71323 (2013).
15. Jung, M., Neugebauer, R. C. & Sippl, W. Inhibitors of NAD Dependent Histone Deacetylases (Sirtuins). Curr. Pharm. Design. 14, 562-573 (2008).
16. Pereira, A. C. et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl. Aca. Sci. USA. 104, 5638-5643 (2007).
17. Van Praag, H., Shubert, T., Zhao, C. & Gage, F. H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25, 8680-8685 (2005).
18. Shimazu, K. et al . NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis. Learn, Memory 13, 307-315 (2006).
19. Zhao, X. et al . Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl. Aca. Sci. USA 100, 6777-6782 (2003).
20. Suri, D. et al. Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition. Biol. Psychiat. 73, 658-666 (2012).
21. Saxe, M. D. et al. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Natl. Aca. Sci. USA 103, 17501-17506 (2006).
22. Surget, A. et al. Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol. Psychiat. 64, 293-301 (2008).
23. Raber, J. et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat. Res. 162, 39-47 (2004).
24. Larsen, M. H.,Mikkelsen, J. D., Hay-Schmidt, A. & Sandi, C. Regulation of brainderived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment. J. Psychiatr. Res. 44, 808-816 (2010).
25. Duric, V. et al . A negative regulator of MAP kinase causes depressive behavior. Nat. Med. 16, 1328-1332 (2010).
26. Noonan, M. A., Bulin, S. E., Fuller, D. C. & Eisch, A. J. Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. J Neurosci. 30, 304-315 (2010).
27. Snyder, J., Hong, N.,McDonald, R. &Wojtowicz, J. A role for adult neurogenesis in spatial long-term memory. Neuroscience 130, 843-852 (2005).
28. Lu, W. Y. et al. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 29, 243-254 (2001).