Postconditioning with simvastatin decreases myocardial injury in rats following acute myocardial ischemia

Experimental and Therapeutic Medicine

Volumn 9, Issue 4, 2015, Pages 1166-1170

  Yao, Heng Chen ^a,b   Yang, Lan Ju ^b   Han, Qian Feng ^b   Wang, Lan Hua ^b   Wu, Lei ^b   Zhang, Chun Yan ^b   Tian, Ke Li ^c   Zhang, Mei ^a  

^a SHANDONG UNIVERSITY   (China)

^b LIAOCHENG PEOPLE'S HOSPITAL   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Acute myocardial infarction; High mobility group box 1; Postconditioning; Simvastatin

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; MALONALDEHYDE; MONOCLONAL ANTIBODY; SIMVASTATIN; SUPEROXIDE DISMUTASE; TRIPHENYLTETRAZOLIUM; TROPONIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ELECTROCARDIOGRAPHY; HEART INFARCTION SIZE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISCHEMIC POSTCONDITIONING; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; ST SEGMENT ELEVATION; WESTERN BLOTTING;

EID: 84923007184     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2273     Document Type: Article

References (29)

1. Lakhan SE, Kirchgessner A and Hofer M: Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 7: 97, 2009.
2. Oozawa S, Mori S, Kanke T, Takahashi H, Liu K, Tomono Y, Asanuma M, Miyazaki I, Nishibori M and Sano S: Effects of HMGB1 on ischemia reperfusion injury in the rat heart. Circ J 72: 1178-1184, 2008.
3. Andrassy M, Volz HC, Riedle N, Gitsioudis G, Seidel C, Laohachewin D, Zankl AR, Kaya Z, Bierhaus A, Giannitsis E, et al: HMGB1 as a predictor of infarct transmurality and functional recovery in patients with myocardial infarction. J Intern Med 270: 245-253, 2011.
4. Yao HC, Zhao AP, Han QF, Wu L, Yao DK and Wang LX: Correlation between serum high mobility group box 1 levels and high sensitivity C reactive protein and troponin I in patients with coronary artery disease. Exp Ther Med 6: 121-124, 2013.
5. Wang CY, Liu PY and Liao JK: Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med 14: 37-44, 2008.
6. Ke D, Fang J, Fan L, Chen Z and Chen L: Regulatory T cells contribute to rosuvastatin induced cardioprotection against ischemia reperfusion injury. Coron Artery Dis 24: 334-341, 2013.
7. Yao HC, Han QF, Wang LH, Wu L, Liu T, Fu ZL, Tian KL and Zhang M: Simvastatin attenuates myocardial injury by inhibiting the expression of high mobility group box 1 in myocardium of rats following acute myocardial infarction. Exp Clin Cardiol 20: 2342-2342, 2014.
8. Eltzschig HK and Eckle T: Ischemia and reperfusion - from mechanism to translation. Nat Med 17: 1391-1401, 2011.
9. Fan Q, Yang XC, Liu Y, Wang LF, Liu SH, Ge YG, Chen ML, Wang W, Zhang LK, Irwin MG and Xia Z. Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans. Clin Sci (Lond) 120: 251-261, 2011.
10. Jiang XJ, Ai CY, Shi EY, Nakajima Y and Ma H: Neuroprotection against spinal cord ischemia reperfusion injury induced by different ischemic postconditioning methods: Roles of phosphatidylinositol 3-kinase-Akt and extracellular signal-regulated kinase. Anesthesiology 111: 1197-1205, 2009.
11. Kong Y, Rogers MR and Qin X. Effective neuroprotection by ischemic postconditioning is associated with a decreased expression of RGMa and inflammation mediators in ischemic rats. Neurochem Res 38: 815-825, 2013.
12. Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H and Chen Z: Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat. Transpl Int 21: 364-371, 2008.
13. Knudsen AR, Kannerup AS, Dich R, Funch-Jensen P, Grønbaek H, Kruhøffer M and Mortensen FV: Ischemic pre- and postconditioning has pronounced effects on gene expression profiles in the rat liver after ischemia/reperfusion. Am J Physiol Gastrointest Liver Physiol 303: G482-G489, 2012.
14. Liang H, Yu F, Tong Z, Yuan B and Wang C. Effect of ischemia postconditioning on skeletal muscle oxidative injury, mTOR, Bax, Bcl-2 proteins expression, and HIF-1α/β-actin mRNA, IL-6/β-actin mRNA and caveolin-3/β-actin mRNA expression in ischemia-reperfusion rabbits. Mol Biol Rep 40: 507-514, 2013.
15. Cao QF, Qu MJ, Yang WQ, Wang DP, Zhang MH and Di SB. Ischemia postconditioning preventing lung ischemia reperfusion injury. Gene 554: 120-124, 2015.
16. Leng YF, Zhang Y, Zhang Y, Xue X, Wang T and Kang YQ. Ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats. Braz J Med Biol Res 44: 411-417, 2011.
17. Zhao ZQ. Postconditioning in reperfusion injury: A status report. Cardiovasc Drugs Ther 24: 265-279, 2010.
18. Yao HC, Liu T, Meng XY, Han QF, Zhang M and Wang LX: Effect of basic fibroblast growth factor on the myocardial expression of hypoxia inducible factor 1α and vascular endothelial growth factor following acute myocardial infarction. Heart Lung Circ 22: 946-951, 2013.
19. Braunwald E and Kloner RA: Myocardial reperfusion: a double edged sword? J Clin Invest 76: 1713-1719, 1985.
20. Skyschally A, Gres P, Hoffmann S, Haude M, Erbel R, Schulz R and Heusch G: Bidirectional role of tumor necrosis factor alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction. Circ Res 100: 140-146, 2007.
21. Bonaldi T, Talamo F, Scaffidi P, Ferrera D, Porto A, Bachi A, Rubartelli A, Agresti A and Bianchi ME: Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 22: 5551-5560, 2003.
22. Ren D, Sun R and Wang S: Role of inducible nitric oxide synthase expressed by alveolar macrophages in high mobility group box 1 induced acute lung injury. Inflamm Res 55: 207-215, 2006.
23. Prasad A, Stone GW, Holmes DR and Gersh B: Reperfusion injury, microvascular dysfunction, and cardioprotection: the 'dark side' of reperfusion. Circulation 120: 2105-2112, 2009.
24. Kitano K, Usui S, Ootsuji H, Takashima S, Kobayashi D, Murai H, Furusho H, Nomura A, Kaneko S and Takamura M: Rho kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury. PLoS One 9: e92242, 2014.
25. Tsung A, Klune JR, Zhang X, Jeyabalan G, Cao Z, Peng X, Stolz DB, Geller DA, Rosengart MR and Billiar TR: HMGB1 release induced by liver ischemia involves Toll like receptor 4 dependent reactive oxygen species production and calcium mediated signaling. J Exp Med 204: 2913-2923, 2007.
26. Hu X, Zhou X, He B, Xu C, Wu L, Cui B, Wen H, Lu Z and Jiang H: Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol 638: 84-89, 2010.
27. Du X, Hu X and Wei J: Postconditioning with rosuvastatin reduces myocardial ischemia reperfusion injury by inhibiting high mobility group box 1 protein expression. Exp Ther Med 7: 117-120, 2014.
28. Ding HS, Yang J, Chen P, Yang J, Bo SQ, Ding JW and Yu QQ: The HMGB1 TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene 527: 389-393, 2013.
29. Li XD, Yang YJ, Geng YJ, et al: The cardioprotection of simvastatin in reperfused swine hearts relates to the inhibition of myocardial edema by modulating aquaporins via the PKA pathway. Int J Cardiol 167: 2657-2666, 2013.