Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection

Journal of Hepatology

Volumn 62, Issue 3, 2015, Pages 512-518

  Huang, Chung Feng ^a,b,c,d   Dai, Chia Yen ^b,d   Yeh, Ming Lun ^a,b   Huang, Ching I ^b   Tai, Chi Ming ^a,e   Hsieh, Meng Hsuan ^b   Liang, Po Cheng ^b   Lin, Yi Hung ^b   Hsieh, Ming Yen ^b,c   Yang, Hua Ling ^b   Huang, Jee Fu ^b,d,f   Lin, Zu Yau ^b,d   Chen, Shinn Cherng ^b,d   Yu, Ming Lung ^b,d,g   Chuang, Wan Long ^b,d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e I SHOU UNIVERSITY   (Taiwan)

^f KAOHSIUNG MUNICIPAL HSIAO KANG HOSPITAL   (Taiwan)

^g NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

CHC; DM; HCV; Liver fibrosis; PNPLA3; SNP

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN; GENOMIC DNA; ADIPONUTRIN, HUMAN; MEMBRANE PROTEIN; TRIACYLGLYCEROL LIPASE;

ADULT; AGE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLELE; ALPHA FETOPROTEIN BLOOD LEVEL; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE ASSOCIATION; DISEASE SEVERITY; FATTY LIVER; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HETEROZYGOTE; HIGH RISK PATIENT; HUMAN; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 GENE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE COUNT; AGED; BIOLOGICAL MODEL; CHRONIC HEPATITIS C; COHORT ANALYSIS; COMPLICATION; DOMINANT GENE; GENETIC PREDISPOSITION; GENETICS; LIVER CIRRHOSIS; PATHOLOGY; RECESSIVE GENE;

ADULT; AGED; COHORT STUDIES; DIABETES COMPLICATIONS; FEMALE; GENES, DOMINANT; GENES, RECESSIVE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HEPATITIS C, CHRONIC; HUMANS; LIPASE; LIVER CIRRHOSIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84923006443     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.10.011     Document Type: Article

References (44)

1. G.M. Lauer, and B.D. Walker Hepatitis C virus infection N Engl J Med 345 2001 41 52
2. C.F. Huang, W.L. Chuang, and M.L. Yu Chronic hepatitis C infection in the elderly Kaohsiung J Med Sci 27 2011 533 537
3. T. Poynard, P. Bedossa, and P. Opolon Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups Lancet 349 1997 825 832
4. M. Wright, R. Goldin, A. Fabre, J. Lloyd, H. Thomas, and C. Trepo Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study Gut 52 2003 574 579
5. J.F. Huang, M.L. Yu, C.M. Lee, C.Y. Dai, N.J. Hou, and M.Y. Hsieh Sustained virological response to interferon reduces cirrhosis in chronic hepatitis C: a 1,386-patient study from Taiwan Aliment Pharmacol Ther 25 2007 1029 1037
6. M.L. Yu, S.M. Lin, C.M. Lee, C.Y. Dai, W.Y. Chang, and S.C. Chen A simple noninvasive index for predicting long-term outcome of chronic hepatitis C after interferon-based therapy Hepatology 44 2006 1086 1097
7. S.B. Missiha, M. Ostrowski, and E.J. Heathcote Disease progression in chronic hepatitis C: modifiable and nonmodifiable factors Gastroenterology 134 2008 1699 1714
8. E. Patin, Z. Kutalik, J. Guergnon, S. Bibert, B. Nalpas, and E. Jouanguy Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection Gastroenterology 143 2012 403, 1244-1252
9. Y. Urabe, H. Ochi, N. Kato, V. Kumar, A. Takahashi, and R. Muroyama A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region J Hepatol 58 2013 875 882
10. N. Goossens, and F. Negro Is genotype 3 of the hepatitis C virus the new villain? Hepatology 59 2014 2403 2412
11. F. Kanwal, J.R. Kramer, J. Ilyas, Z. Duan, and H.B. El-Serag HCV genotype 3 is associated with an increased risk of cirrhosis and hepatocellular cancer in a national sample of U.S. Veterans with HCV Hepatology 60 2014 98 105
12. M. Ydreborg, J. Westin, K. Rembeck, M. Lindh, H. Norrgren, and A. Holmberg Impact of Il28b-related single nucleotide polymorphisms on liver transient elastography in chronic hepatitis C infection PLoS One 8 2013 e80172
13. M. Noureddin, E.C. Wright, H.J. Alter, S. Clark, E. Thomas, and R. Chen Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: a longitudinal analysis Hepatology 58 2013 1548 1557
14. S. Romeo, J. Kozlitina, C. Xing, A. Pertsemlidis, D. Cox, and L.A. Pennacchio Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease Nat Genet 40 2008 1461 1465
15. Y. Rotman, C. Koh, J.M. Zmuda, D.E. Kleiner, and T.J. Liang The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease Hepatology 52 2010 894 903
16. S. Sookoian, and C.J. Pirola Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease Hepatology 53 2011 1883 1894
17. M. Nakamura, T. Kanda, S. Nakamoto, T. Miyamura, X. Jiang, and S. Wu No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV PLoS One 8 2013 e81312
18. L. Valenti, M. Rumi, E. Galmozzi, A. Aghemo, B. Del Menico, and S. De Nicola Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C Hepatology 53 2011 791 799
19. E. Trepo, P. Pradat, A. Potthoff, Y. Momozawa, E. Quertinmont, and T. Gustot Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C Hepatology 54 2011 60 69
20. E. Estrabaud, M. Vidaud, P. Marcellin, and T. Asselah Genomics and HCV infection: progression of fibrosis and treatment response J Hepatol 57 2012 1110 1125
21. W. Dunn, M. O'Neil, J. Zhao, C.H. Wu, B. Roberts, and S. Chakraborty Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C Hepatology 59 2014 453 460
22. J.F. Huang, M.L. Yu, C.Y. Dai, and W.L. Chuang Glucose abnormalities in hepatitis C virus infection Kaohsiung J Med Sci 29 2013 61 68
23. J.E. Everhart, A.S. Lok, H.Y. Kim, T.R. Morgan, K.L. Lindsay, and R.T. Chung Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial Gastroenterology 137 2009 549 557
24. I.J. Hickman, and G.A. Macdonald Impact of diabetes on the severity of liver disease Am J Med 120 2007 829 834
25. P. Angulo, J.C. Keach, K.P. Batts, and K.D. Lindor Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis Hepatology 30 1999 1356 1362
26. K. Kantartzis, A. Peter, F. Machicao, J. Machann, S. Wagner, and I. Konigsrainer Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene Diabetes 58 2009 2616 2623
27. E.K. Speliotes, J.L. Butler, C.D. Palmer, B.F. Voight, and J.N. Hirschhorn PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease Hepatology 52 2010 904 912
28. T. Muller, S. Buch, T. Berg, J. Hampe, and F. Stickel Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C J Hepatol 55 2011 732 733
29. R. Zampino, N. Coppola, G. Cirillo, A. Boemio, M. Pisaturo, and A. Marrone Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C J Viral Hepat 20 2013 517 523
30. H. Okamoto, H. Tokita, M. Sakamoto, M. Horikita, M. Kojima, and H. Iizuka Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection J Gen Virol 74 1993 2385 2390
31. P.J. Scheuer Classification of chronic viral hepatitis: a need for reassessment J Hepatol 13 1991 372 374
32. C.W. Wang, H.Y. Lin, S.J. Shin, M.L. Yu, Z.Y. Lin, and C.Y. Dai The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population Liver Int 31 2011 1326 1331
33. M. Vigano, L. Valenti, P. Lampertico, F. Facchetti, B.M. Motta, and R. D'Ambrosio Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B Hepatology 58 2013 1245 1252
34. E. Trepo, T. Gustot, D. Degre, A. Lemmers, L. Verset, and P. Demetter Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease J Hepatol 55 2011 906 912
35. A.G. Singal, H. Manjunath, A.C. Yopp, M.S. Beg, J.A. Marrero, and P. Gopal The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis Am J Gastroenterol 109 2014 325 334
36. M. Miyashita, T. Ito, M. Sakaki, A. Kajiwara, H. Nozawa, and K. Hiroishi Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C J Viral Hepat 19 2012 608 614
37. S. Romeo, I. Huang-Doran, M.G. Baroni, and A. Kotronen Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein Curr Opin Lipidol 21 2010 247 252
38. G. Leandro, A. Mangia, J. Hui, P. Fabris, L. Rubbia-Brandt, and G. Colloredo Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data Gastroenterology 130 2006 1636 1642
39. M.J. Walsh, D.M. Vanags, A.D. Clouston, M.M. Richardson, D.M. Purdie, and J.R. Jonsson Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury Hepatology 39 2004 1230 1238
40. L. Valenti, A. Al-Serri, A.K. Daly, E. Galmozzi, R. Rametta, and P. Dongiovanni Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease Hepatology 51 2010 1209 1217
41. M.H. Lee, S.N. Lu, Y. Yuan, H.I. Yang, C.L. Jen, and S.L. You Development and validation of a clinical scoring system for predicting risk of HCC in asymptomatic individuals seropositive for anti-HCV antibodies PLoS One 9 2014 e94760
42. C. Colletta, C. Smirne, C. Fabris, P. Toniutto, R. Rapetti, and R. Minisini Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases Hepatology 42 2005 838 845
43. A.S. Lok, J.E. Everhart, R.T. Chung, L. Padmanabhan, J.K. Greenson, and M.L. Shiffman Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial Clin Gastroenterol Hepatol 5 2007 245 254
44. J.M. Petit, B. Guiu, D. Masson, L. Duvillard, V. Jooste, and P. Buffier PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes Liver Int 31 2011 1332 1336