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Volumn 20, Issue 8, 2013, Pages 517-523

Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C

Author keywords

abdominal fat; APOC3; chronic hepatitis C; liver steatosis; PNPLA3

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN C3; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3; PHOSPHOLIPASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84879798869     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12053     Document Type: Article
Times cited : (52)

References (34)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P,. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G,. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-1364.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 3
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW,. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279: 48968-48975.
    • (2004) J Biol Chem , vol.279 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5    Gross, R.W.6
  • 4
    • 84894403460 scopus 로고
    • Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice
    • Ito Y, Azrolan N, O'Connell A, Walsh A, Breslow JL,. Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science 1990; 17: 249.
    • (1990) Science , vol.17 , pp. 249
    • Ito, Y.1    Azrolan, N.2    O'Connell, A.3    Walsh, A.4    Breslow, J.L.5
  • 5
    • 2642551767 scopus 로고    scopus 로고
    • The role and mode of action of apolipoproteins CIII and AV: Synergistic actors in triglyceride metabolism?
    • van Dijk KW, Rensen PC, Voshol PJ, Havekes LM,. The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism? Curr Opin Lipidol 2004; 15: 239-246.
    • (2004) Curr Opin Lipidol , vol.15 , pp. 239-246
    • Van Dijk, K.W.1    Rensen, P.C.2    Voshol, P.J.3    Havekes, L.M.4
  • 6
    • 84894404796 scopus 로고    scopus 로고
    • A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    • Pollin TI, Damcott CM, Shen H, et al,. A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science 2008; 12: 322.
    • (2008) Science , vol.12 , pp. 322
    • Pollin, T.I.1    Damcott, C.M.2    Shen, H.3
  • 7
    • 77949895032 scopus 로고    scopus 로고
    • A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
    • He S, McPhaul C, Li JZ, et al,. A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis. J Biol Chem 2010; 285: 6706-6715.
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3
  • 8
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al,. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-1465.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 9
    • 77956630787 scopus 로고    scopus 로고
    • GIANT Consortium; MIGen Consortium; NASH CRN, Hirschhorn JN. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    • Speliotes EK, Butler JL, Palmer CD, Voight BF,. GIANT Consortium; MIGen Consortium; NASH CRN, Hirschhorn JN. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology 2010; 52: 904-912.
    • (2010) Hepatology , vol.52 , pp. 904-912
    • Speliotes, E.K.1    Butler, J.L.2    Palmer, C.D.3    Voight, B.F.4
  • 10
    • 80055057797 scopus 로고    scopus 로고
    • Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
    • Lee HY, Birkenfeld AL, Jornayvaz FR, et al,. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology 2011; 54: 1650-1660.
    • (2011) Hepatology , vol.54 , pp. 1650-1660
    • Lee, H.Y.1    Birkenfeld, A.L.2    Jornayvaz, F.R.3
  • 11
    • 84894403581 scopus 로고    scopus 로고
    • Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    • Petersen KF, Dufour S, Hariri A, et al,. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 2010; 25: 362.
    • (2010) N Engl J Med , vol.25 , pp. 362
    • Petersen, K.F.1    Dufour, S.2    Hariri, A.3
  • 12
    • 79251523832 scopus 로고    scopus 로고
    • Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance
    • Kozlitina J, Boerwinkle E, Cohen JC, Hobbs HH,. Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance. Hepatology 2011; 53: 467-474.
    • (2011) Hepatology , vol.53 , pp. 467-474
    • Kozlitina, J.1    Boerwinkle, E.2    Cohen, J.C.3    Hobbs, H.H.4
  • 13
    • 81255198296 scopus 로고    scopus 로고
    • The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver
    • Valenti L, Nobili V, Al-Serri A, et al,. The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver. J Hepatol 2011; 55: 1409-1414.
    • (2011) J Hepatol , vol.55 , pp. 1409-1414
    • Valenti, L.1    Nobili, V.2    Al-Serri, A.3
  • 14
    • 79952222716 scopus 로고    scopus 로고
    • Patatin-Like Phospholipase Domain-Containing 3 I148M Polymorphism, Steatosis, and Liver Damage in Chronic Hepatitis C
    • Valenti L, Rumi MG, Galmozzi E, et al,. Patatin-Like Phospholipase Domain-Containing 3 I148M Polymorphism, Steatosis, and Liver Damage in Chronic Hepatitis C. Hepatology 2011; 53: 791-799.
    • (2011) Hepatology , vol.53 , pp. 791-799
    • Valenti, L.1    Rumi, M.G.2    Galmozzi, E.3
  • 15
    • 79959554057 scopus 로고    scopus 로고
    • Impact of Patatin-Like Phospholipase-3 (rs738409 C>G) Polymorphism on Fibrosis Progression and Steatosis in Chronic Hepatitis C
    • Trepo E, Pradat P, Potthoff A, et al,. Impact of Patatin-Like Phospholipase-3 (rs738409 C>G) Polymorphism on Fibrosis Progression and Steatosis in Chronic Hepatitis C. Hepatology 2011; 54: 60-69.
    • (2011) Hepatology , vol.54 , pp. 60-69
    • Trepo, E.1    Pradat, P.2    Potthoff, A.3
  • 16
    • 84860389885 scopus 로고    scopus 로고
    • Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C
    • Müller T, Buch S, Berg T, Hampe J, Stickel F,. Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C. J Hepatol 2011; 55: 732-733.
    • (2011) J Hepatol , vol.55 , pp. 732-733
    • Müller, T.1    Buch, S.2    Berg, T.3    Hampe, J.4    Stickel, F.5
  • 17
    • 84860389137 scopus 로고    scopus 로고
    • Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis
    • Cai T, Dufour JF, Tilman BM, et al,. Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis. J Hepatol 2011; 55: 529-535.
    • (2011) J Hepatol , vol.55 , pp. 529-535
    • Cai, T.1    Dufour, J.F.2    Tilman, B.M.3
  • 18
    • 79955085671 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma
    • Corradini SG, Burza MA, Molinaro A, Romeo S,. Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma. Hepatology 2011; 53: 1776.
    • (2011) Hepatology , vol.53 , pp. 1776
    • Corradini, S.G.1    Burza, M.A.2    Molinaro, A.3    Romeo, S.4
  • 19
    • 70350579034 scopus 로고    scopus 로고
    • Long-term outcome of hepatitis B and hepatitis C virus co-infection and single HBV infection acquired in youth
    • Zampino R, Marrone A, Merola A, et al,. Long-term outcome of hepatitis B and hepatitis C virus co-infection and single HBV infection acquired in youth. J Med Virol 2009; 81: 2012-2020.
    • (2009) J Med Virol , vol.81 , pp. 2012-2020
    • Zampino, R.1    Marrone, A.2    Merola, A.3
  • 20
    • 0029039362 scopus 로고
    • Histological grading and staging of chronic hepatitis
    • Ishak K, Baptista A, Bianchi L, et al,. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-699.
    • (1995) J Hepatol , vol.22 , pp. 696-699
    • Ishak, K.1    Baptista, A.2    Bianchi, L.3
  • 21
    • 0033638049 scopus 로고    scopus 로고
    • High-speed detection of blood-borne hepatitis C virus RNA by single-tube real-time fluorescence reverse-transcription PCR with LightCycler
    • Ratge D, Scheiblhuber B, Nitsche M, Knabbe C,. High-speed detection of blood-borne hepatitis C virus RNA by single-tube real-time fluorescence reverse-transcription PCR with LightCycler. Clin Chem. 2000; 46: 1987-1989.
    • (2000) Clin Chem , vol.46 , pp. 1987-1989
    • Ratge, D.1    Scheiblhuber, B.2    Nitsche, M.3    Knabbe, C.4
  • 22
    • 65449154684 scopus 로고    scopus 로고
    • HBV superinfection in HCV chronic carriers: A disease that is frequently severe but associated with the eradication of HCV
    • Sagnelli E, Coppola N, Pisaturo M, et al,. HBV superinfection in HCV chronic carriers: a disease that is frequently severe but associated with the eradication of HCV. Hepatology 2009; 49: 1090-1097.
    • (2009) Hepatology , vol.49 , pp. 1090-1097
    • Sagnelli, E.1    Coppola, N.2    Pisaturo, M.3
  • 23
    • 82155164171 scopus 로고    scopus 로고
    • The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat
    • Miraglia del Giudice E, Grandone A, Cirillo G, et al,. The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat. PLoS ONE 2011; 6 (11): e27933.
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Miraglia Del Giudice, E.1    Grandone, A.2    Cirillo, G.3
  • 24
    • 77954157546 scopus 로고    scopus 로고
    • On the use of variance per genotype as a tool to identify quantitative trait interaction effects: A report from the Women's Genome Health Study
    • Paré G, Cook NR, Ridker PM, Chasman DI,. On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study. PLoS Genet 2010; 6: e1000981.
    • (2010) PLoS Genet , vol.6
    • Paré, G.1    Cook, N.R.2    Ridker, P.M.3    Chasman, D.I.4
  • 25
    • 74249093842 scopus 로고    scopus 로고
    • Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
    • Romeo S, Sentinelli F, Dash S, et al,. Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. Int J Obes 2010; 34: 190-194.
    • (2010) Int J Obes , vol.34 , pp. 190-194
    • Romeo, S.1    Sentinelli, F.2    Dash, S.3
  • 26
    • 77955308935 scopus 로고    scopus 로고
    • The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
    • Romeo S, Sentinelli F, Cambuli VM, et al,. The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life. J Hepatol 2010; 53: 335-338.
    • (2010) J Hepatol , vol.53 , pp. 335-338
    • Romeo, S.1    Sentinelli, F.2    Cambuli, V.M.3
  • 27
    • 84861188878 scopus 로고    scopus 로고
    • Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin
    • Valenti L, Aghemo A, Stättermayer F, et al,. Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin. Aliment Pharmacol Ther 2012; 35 (12): 1434-1442.
    • (2012) Aliment Pharmacol Ther , vol.35 , Issue.12 , pp. 1434-1442
    • Valenti, L.1    Aghemo, A.2    Stättermayer, F.3
  • 28
    • 84860511974 scopus 로고    scopus 로고
    • Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) -482C>T polymorphism on triglyceride concentration in Turkish adults
    • Coban N, Onat A, Guclu-Geyik F, et al,. Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) -482C>T polymorphism on triglyceride concentration in Turkish adults. Clin Chem Lab Med 2011; 2: 285-292.
    • (2011) Clin Chem Lab Med , vol.2 , pp. 285-292
    • Coban, N.1    Onat, A.2    Guclu-Geyik, F.3
  • 29
    • 79957800826 scopus 로고    scopus 로고
    • Elevated levels of triglyceride and triglyceride-rich lipoprotein induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults
    • Lin J, Fang DZ, Du J, et al,. Elevated levels of triglyceride and triglyceride-rich lipoprotein induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults. Ann Nutr Metab 2011; 58 (2): 150-157.
    • (2011) Ann Nutr Metab , vol.58 , Issue.2 , pp. 150-157
    • Lin, J.1    Fang, D.Z.2    Du, J.3
  • 30
    • 73149104856 scopus 로고    scopus 로고
    • Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men
    • Delgado-Lista J, Perez-Jimenez F, Ruano J, et al,. Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men. J Lipid Res 2010; 51 (1): 63-73.
    • (2010) J Lipid Res , vol.51 , Issue.1 , pp. 63-73
    • Delgado-Lista, J.1    Perez-Jimenez, F.2    Ruano, J.3
  • 31
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després JP, Lemieux I,. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-887.
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 32
    • 0038365556 scopus 로고    scopus 로고
    • Waist-to-height ratio, a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women
    • Hsieh SD, Yoshinaga H, Muto T,. Waist-to-height ratio, a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women. Int J Obes Relat Metab Disord 2003; 27: 610-616.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 610-616
    • Hsieh, S.D.1    Yoshinaga, H.2    Muto, T.3
  • 33
    • 78751536418 scopus 로고    scopus 로고
    • Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians
    • Stickel F, Buch S, Lau K, et al,. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians. Hepatology 2011; 53: 86-95.
    • (2011) Hepatology , vol.53 , pp. 86-95
    • Stickel, F.1    Buch, S.2    Lau, K.3
  • 34
    • 80455174482 scopus 로고    scopus 로고
    • The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    • Nischalke HD, Berger C, Luda C, et al,. The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. PLoS ONE 2011; 6 (11): e27087.
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Nischalke, H.D.1    Berger, C.2    Luda, C.3


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