Reduction of HIV-1 infectivity through endoplasmic reticulum-associated degradation-mediated Env depletion

Journal of Virology

Volumn 89, Issue 5, 2015, Pages 2966-2971

  Casini, Antonio ^a   Olivieri, Michele ^a   Vecchi, Lara ^b   Burrone, Oscar R ^c   Cereseto, Anna ^a  

^a UNIVERSITY OF TRENTO   (Italy)

^b FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 160; GP160 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIRION; VIRUS INFECTIVITY; VIRUS PARTICLE; CELL LINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PHYSIOLOGY; PROTEIN DEGRADATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CELL LINE; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HIV ENVELOPE PROTEIN GP160; HIV-1; HUMANS; PROTEOLYSIS;

EID: 84922963943     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02634-14     Document Type: Article

References (24)

1. Checkley MA, Luttge BG, Freed EO. 2011. HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation. J Mol Biol 410:582-608. http://dx.doi.org/10.1016/j.jmb.2011.04.042.
2. Vecchi L, Petris G, Bestagno M, Burrone OR. 2012. Selective targeting of proteins within secretory pathway for endoplasmic reticulum-associated degradation. J Biol Chem 287:20007-20015. http://dx.doi.org/10.1074/jbc.M112.355107.
3. Mueller B, Klemm EJ, Spooner E, Claessen JH, Ploegh HL. 2008. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci USA 105:12325-12330. http://dx.doi.org/10.1073/pnas.0805371105.
4. Abacioglu YH, Fouts TR, Laman JD, Claassen E, Pincus SH, Moore JP, Roby CA, Kamin-Lewis R, Lewis GK. 1994. Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies. AIDS Res Hum Retroviruses 10:371-381. http://dx.doi.org/10.1089/aid.1994.10.371.
5. Wu X, Yang Z-Y, Li Y, Hogerkorp C-M, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L, Longo NS, McKee K, O'Dell S, Louder MK, Wycuff DL, Feng Y, Nason M, Doria-Rose N, Connors M, Kwong PD, Roederer M, Wyatt RT, Nabel GJ, Mascola JR. 2010. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329:856-861. http://dx.doi.org/10.1126/science.1187659.
6. Haas J, Park EC, Seed B. 1996. Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr Biol 6:315-324. http://dx.doi.org/10.1016/S0960-9822(02)00482-7.
7. Petris G, Bestagno M, Arnoldi F, Burrone OR. 2014. New tags for recombinant protein detection and O-glycosylation reporters. PLoS One 9:e96700. http://dx.doi.org/10.1371/journal.pone.0096700.
8. Dul JL, Burrone OR, Argon Y. 1992. A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine. J Immunol 149:1927-1933.
9. Dunn SJ, Ward RL, McNeal MM, Cross TL, Greenberg HB. 1993. Identification of a new neutralization epitope on VP7 of human serotype 2 rotavirus and evidence for electropherotype differences caused by single nucleotide substitutions. Virology 197:397-404. http://dx.doi.org/10.1006/viro.1993.1601.
10. He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR. 1995. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J Virol 69:6705-6711.
11. Verrier FC, Charneau P, Altmeyer R, Laurent S, Borman AM, Girard M. 1997. Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate. Proc Natl Acad Sci USA 94:9326-9331. http://dx.doi.org/10.1073/pnas.94.17.9326.
12. Pizzato M, Erlwein O, Bonsall D, Kaye S, Muir D, McClure MO. 2009. A one-step SYBR green I-based product-enhanced reverse transcriptase assay for the quantitation of retroviruses in cell culture supernatants. J Virol Methods 156:1-7. http://dx.doi.org/10.1016/j.jviromet.2008.10.012.
13. Nielsen MH, Pedersen FS, Kjems J. 2005. Molecular strategies to inhibit HIV-1 replication. Retrovirology 2:10. http://dx.doi.org/10.1186/1742-4690-2-10.
14. Buonocore L, Rose J. 1990. Prevention of HIV-1 glycoprotein transport by soluble CD4 retained in the endoplasmic reticulum. Nature 345:625-628.
15. Buonocore L, Rose JK. 1993. Blockade of human immunodeficiency virus type 1 production in CD4+T cells by an intracellular CD4 expressed under control of the viral long terminal repeat. Proc Natl Acad Sci USA 90:2695-2699. http://dx.doi.org/10.1073/pnas.90.7.2695.
16. Degar S, Johnson J, Boritz E, Rose J. 1996. Replication of primary HIV-1 isolates is inhibited in PM1 cells expressing sCD4-KDEL. Virology 429: 424-429.
17. San José E, Muñoz-Fernández MA, Alarcón B. 1998. Retroviral vectormediated expression in primary human T cells of an endoplasmic reticulum-retained CD4 chimera inhibits human immunodeficiency virus type-1 replication. Hum Gene Ther 9:1345-1357. http://dx.doi.org/10.1089/hum.1998.9.9-1345.
18. Marasco WA, Haseltine WA, Chen SY. 1993. Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody. Proc Natl Acad Sci USA 90:7889-7893. http://dx.doi.org/10.1073/pnas.90.16.7889.
19. Zhou P, Goldstein S, Devadas K, Tewari D, Notkins AL. 1998. Cells transfected with a non-neutralizing antibody gene are resistant to HIV infection: targeting the endoplasmic reticulum and trans-Golgi network. J Immunol 160:1489-1496.
20. Liu F, Kumar M, Ma Q, Duval M, Kuhrt D, Junghans R, Posner M, Cavacini L. 2005. Human single-chain antibodies inhibit replication of human immunodeficiency virus type 1 (HIV-1). AIDS Res Hum Retroviruses 21:876-881. http://dx.doi.org/10.1089/aid.2005.21.876.
21. Chen SY, Bagley J, Marasco WA. 1994. Intracellular antibodies as a new class of therapeutic molecules for gene therapy. Hum Gene Ther 5:595-601. http://dx.doi.org/10.1089/hum.1994.5.5-595.
22. Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529. http://dx.doi.org/10.1038/nrm2199.
23. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H. 2002. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16:1345-1355. http://dx.doi.org/10.1101/gad.992302.
24. Leitman J, Ulrich Hartl F, Lederkremer GZ. 2013. Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress. Nat Commun 4:2753. http://dx.doi.org/10.1038/ncomms3753.