Zebrafish as a new model for phenotype-based screening of positive inotropic agents

Chemical Biology and Drug Design

Volumn 85, Issue 3, 2015, Pages 253-258

  Tang, Chunlei ^a   Xie, Desheng ^a   Feng, Bainian ^a,b  

^a JIANGNAN UNIVERSITY   (China)

^b Jiangshu Alpha Biopharmaceuticals Inc   (China)

Author keywords

Heart failure; Phenotype based; Positive inotropic agent; Zebrafish

Indexed keywords

AF 001; DIGOXIN; INOTROPIC AGENT; TERFENADINE; UNCLASSIFIED DRUG; CARDIOTONIC AGENT;

ANIMAL EXPERIMENT; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; CONTROLLED STUDY; DRUG SCREENING; HEART FAILURE; HEART LEFT ATRIUM; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART RATE; HEART SIZE; HEART VENTRICLE PRESSURE; INOTROPISM; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; BLOOD PRESSURE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HEART; HEART MUSCLE; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA; DANIO RERIO;

ANIMALS; BLOOD PRESSURE; CARDIOTONIC AGENTS; DIGOXIN; DISEASE MODELS, ANIMAL; EMBRYO, NONMAMMALIAN; HEART; HEART FAILURE; HEART RATE; MALE; MYOCARDIUM; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; TERFENADINE; ZEBRAFISH;

EID: 84922962427     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12389     Document Type: Article

References (20)

1. Tamargo J., Lopez-Sendon J. (2011) Novel therapeutic targets for the treatment of heart failure. Nat Rev Drug Discov;10:536-555.
2. Fang J., Mensah G.A., Croft J.B., Keenan N.L. (2008) Heart failure-related hospitalization in the US, 1979 to 2004. J Am Coll Cardiol;52:428-434.
3. Teerlink J.R. (2009) A novel approach to improve cardiac performance: cardiac myosin activators. Heart Fail Rev;14:289-298.
4. Felker G.M., Pang P.S., Adams K.F., Cleland J.G.F., Cotter G., Dickstein K., Filippatos G.S. et al. (2010) Clinical trials of pharmacological therapies in acute heart failure syndromes lessons learned and directions forward. Circ Heart Fail;3:314-325.
5. Gheorghiade M., Pang P.S. (2009) Acute heart failure syndromes. J Am Coll Cardiol;53:557-573.
6. Tamargo J., Amoros I., Barana A., Caballero R., Delpon E. (2010) New investigational drugs for the management of acute heart failure syndromes. Curr Med Chem;17:363-390.
7. van Hees H.W.H., van der Heijden H.F.M., Ottenheijm C.A.C., Heunks L.M.A., Pigmans C.J.C., Verheugt F.W.A., Brouwer R.M. et al. (2007) Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats. Am J Physiol Heart Circ Physiol;293:H819-H828.
8. Shen Y.T., Lynch J.J., Shannon R.P., Wiedmann R.T. (1999) A novel heart failure model induced by sequential coronary artery occlusions and tachycardiac stress in awake pigs. Am J Physiol Heart Circ Physiol;277:H388-H398.
9. Zon L.I., Peterson R.T. (2005) In vivo drug discovery in the zebrafish. Nat Rev Drug Discov;4:35-44.
10. Huang C.C., Monte A., Cook J.M., Kabir M.S., Peterson K.P. (2013) Zebrafish heart failure models for the evaluation of chemical probes and drugs. Assay Drug Dev Technol;11:561-572.
11. Das B.C., McCormick L., Thapa P., Karki R., Evans T. (2013) Use of zebrafish in chemical biology and drug discovery. Future Med Chem;5:2103-2116.
12. Bowman T.V., Zon L.I. (2010) Swimming into the future of drug discovery. In vivo chemical screens in zebrafish. ACS Chem Biol;5:159-161.
13. Lieschke G.J., Currie P.D. (2007) Animal models of human disease: zebrafish swim into view. Nat Rev Genet;8:353-367.
14. Peterson R.T., Nass R., Boyd W.A., Freedman J.H., Dong K., Narahashi T. (2008) Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology; 29:546-555.
15. Westerfield M. (1993) The Zebrafish Book: A Guide for the Laboratory use of Zebrafish (Brachydanio Rerio). Eugene, OR: University of Oregon Press.
16. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. (1995) Stages of embryonic-development of the zebrafish. Dev Dyn;203:253-310.
17. Matrone G., Taylor J.M., Wilson K.S., Baily J., Love G.D., Girkin J.M., Mullins J.J. et al. (2013) Laser-targeted ablation of the zebrafish embryonic ventricle: a novel model of cardiac injury and repair. Int J Cardiol; 168:3913-3919.
18. Milan D.J., Peterson T.A., Ruskin J.N., Peterson R.T., MacRae C.A. (2003) Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation; 107:1355-1358.
19. Goldhaber J.I., Hamilton M.A. (2010) Role of inotropic agents in the treatment of heart failure. Circulation; 121:1655-1660.
20. Tamargo J., Caballero R., Gomez R., Barana A., Amoros I., Delpon E. (2009) Investigational positive inotropic agents for acute heart failure. Cardiovasc Haematol Disord Drug Targets;9:193-205.