Identification of Nanoscale Ingredients in Commercial Food Products and their Induction of Mitochondrially Mediated Cytotoxic Effects on Human Mesenchymal Stem Cells

Journal of Food Science

Volumn 80, Issue 2, 2015, Pages N459-N464

  Athinarayanan, Jegan ^a   Alshatwi, Ali A ^a   Periasamy, Vaiyapuri S ^a   Al Warthan, Abdulrahman A ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Food additives; Human mesenchymal stem cells; Oxidative stress

Indexed keywords

FOOD ADDITIVE; NANOMATERIAL; SILICON DIOXIDE; TITANIUM; TITANIUM DIOXIDE;

CELL DIFFERENTIATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; MESENCHYMAL STROMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PARTICLE SIZE; TOXICITY TESTING;

CELL DIFFERENTIATION; CELL SURVIVAL; FOOD ADDITIVES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESENCHYMAL STROMAL CELLS; NANOSTRUCTURES; OXIDATIVE STRESS; PARTICLE SIZE; SILICON DIOXIDE; TITANIUM; TOXICITY TESTS;

EID: 84922913039     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12760     Document Type: Article

References (44)

1. Amit NP, Jorge G. 2011. Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy. Stem Cells Cloning 4:61-72.
2. Andrew DM. 2006. Nanotechnology: assessing the risks. Nano Today 1:22-33.
3. Athinarayanan J, Periasamy VS, Alsaif MA, Alshatwi AA. 2014. Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells. Cell Biol Toxicol 30:89-100.
4. Bankapur A, Krishnamurthy RS, Zachariah E, Santhosh C, Chougule B, Praveen B, Valiathan M, Mathur D. 2012. Micro-Raman spectroscopy of silver nanoparticle induced stress on optically-trapped stem cells. PLoS ONE 7:e35075.
5. Blagosklonny MV, El-Deiry WS. 1996. In-Vitro evaluation of a p53-expressing Adenovirus as an anticancer drug Int. J. Cancer 67:386-92.
6. Borm PJA, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, and others. 2006. The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 3:11-46.
7. Botelho MC, Costa C, Silva S, Costa S, Dhawan A, Oliveira PA, Teixeira JP. 2014. Effects of titanium dioxide nanoparticles in human gastric epithelial cells in vitro, Biomed. Pharmacother 68:59-64.
8. Bournat JC, Chester WB. 2010. Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes 17:446-52.
9. Brun E, Barreau F, Veronesi G, Fayard B, Sorieul S, Chanéac C, Carapito C, Rabilloud T, Mabondzo A, Herlin-Boime N, Carrière M. 2014. Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia Part. Fibre Toxicol 11:13-28.
10. Cao J, Weiqing S, Guanghong Z, Xinglian X, Zengqi P, Zhongliang H. 2010. Morphological and biochemical assessment of apoptosis in different skeletal muscles of bulls during conditioning. J. Anim. Sci 88:3439-44.
11. Chang JS, Chang KL, Hwang DF, Kong ZL. 2007. In vitro cytotoxicity of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ Sci Tech 41:2064-8.
12. Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, Aitken R, Watkins R. 2008. Applications and implications of nanotechnologies for the food sector. Food Addit Contam 25:241-58.
13. Colvin VL. 2003. The potential environment impact of engineered nanomaterials. Nat biotechnol 21:1166-70.
14. Commission Regulation (EU) 2010/257/CE of 25 March 2010 setting up a programme for the re-evaluation of approved food additives in accordance with Regulation (EC) No 1333/2008 of the European Parliament and of the Council on food additives (text with EEA relevance). Off J EU L80/19 26/3/2010.
15. Dekkers S, Krystek P, Peters RJB, Lankveld DPK, Bokkers BGH, Hoeven-Arentzen, PHV, Bouwmeester H, Oomen AG. 2011. Presence and risks of nanosilica in food products. Nanotoxicology 10:1-13.
16. Di Virgilio AL, Reigos M, Arnal PM, Fernández Lorenzo MM. 2010. Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells. J Hazard Mater 177:711-8.
17. Duchen MR. 2004. Roles of mitochondria in health and disease. Diabetes 53:S96-S102.
18. Bleeker EA, de Jong WH, Geertsma RE, Groenewold M, Heugens EH, Koers-Jacquemijns M, van de Meent D, Popma JR, Rietveld AG, Wijnhoven SW, Cassee FR, Oomen AG. 2013. Considerations on the EU definition of a nanomaterial: science to support policy making. Regul Toxicol Pharm 65:119-25
19. EFSA, UK. Current EU approved additives and their E Numbers. 26 November 2010. Available from: http://www.food.gov.uk/safereating/chemsafe/additivesbranch/enumberlist.
20. FDA: Listing of Color Additives Exempt from Certification. 2002. In code of federal regulations Title 21-Food and Drugs; U.S. Washington, DC: Government Printing Office
21. GAO. 2010. Food safety: FDA should strengthen its oversight of food ingredients determined to be generally recognized as safe (GRAS). Washington, DC: Government Accountability Office.
22. Gehrke H, Fruhmesser A, Pelka J, Esselen M, Hecht LL, Blank H, Schuchmann HP, Gerthsen D, Marquardt C, Diabate S, Weiss C, Marko D. 2013. In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells. Nanotox 7:274-93.
23. Gerloff K, Albrecht C, Boots AW, Förster I, Shins RPF. 2009. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotox 3:335-64.
24. Hamburg MA. 2012. FDA's approach to regulation of products of nanotechnology. Science 336:299-300
25. Henchcliffe C, Flint BM. 2008. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neuro 4:600-9.
26. IARC. Carbon black, titanium dioxide and Non-Asbestiform Talc. 2006. Intl. agency for research on cancer (IARC). Lyon, France: Monographs on the evaluation of carcinogenic risks to humans. p 93.
27. Judith HM, Caroline D, Jean-Claude M, Dominic J. 2004. Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 23:2850-60
28. Kessler R. 2011. Engineered nanoparticles in consumer products: understanding a new ingredient. Environ. Health Perspect. 119:A120-A125.
29. Lai James CK, Gayathri A, Sirisha J, Vikas VD, Alok B, Mugdha G, Christopher KD, Solomon WL. 2010. Treatment of human astrocytoma U87 cells with silicon dioxide nanoparticles lowers their survival and alters their expression of mitochondrial and cell signaling proteins. Int J Nanomed 5:715-723.
30. Lara Y, Nguyen TKT, Marilena L, Alexander MS. 2011. Toxicology and clinical potential of nanoparticles. Nano Today 6:585-607.
31. Lin W, Huang YW, Zhou XD, Ma Y. 2006. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 217:252-9.
32. Lowell BB, Gerald IS. 2005. Mitochondrial dysfunction and type 2 diabetes. Science 307:384-7.
33. Napierska D, Thomassen LC, Rabolli V, Lison D, Gonzalez L, Kirsch-Volders M, Martens JA, Hoet PH. 2009. Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells. Small 5:846-53.
34. 2 nanoparticles in human hepatoma HepG2 cells. Nanotoxicology 5:341-53.
35. Stefaan JS, Pilar R, José-María M, Wolfgang JP, Stefaan C, Kevin B. 2011. Cellular toxicity of inorganic nanoparticles: common aspects and guidelines for improved nanotoxicity evaluation. Nano Today 6:446-65.
36. Suski JM, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR. 2012. Relation between mitochondrial membrane potential and ROS formation. Methods Mol Biol 810:183-205.
37. Syed KS, Paul TT, David B, John WE, Liping T. 2010. Nanomaterial cytotoxicity is composition, size, and cell type dependent, Part. Fibre Toxicol 7:22-39.
38. Teeguarden, JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. 2007. Particokinetics in vitro: dosimetry considerations for in vitro nanoparticles toxicity assessments. Toxicol Sci 95:300-12.
39. Teow Y, Asharani PV, Hande MP, Valiyaveettil S. 2011. Health impact and safety of engineered nanomaterials. Chem Commun (Camb) 47:7025-38.
40. 2 nanoparticles: studies on a human monoblastoid cell line. Toxicol In Vitro 22:1689-96.
41. Weir A, Westerhoff P, Fabricius L, Hristovski K, Goetz NV. 2012. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242-50.
42. Wu J, Wang C, Sun J, Xue Y. 2011. Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways. Acs Nano 5:4476-89.
43. Yamashita K, Yoshioka Y, Higashisaka K, Mimura K, Morishita Y, Nozaki M, and others. 2011. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotech 6:321-8.
44. Yu JX, Li TH. 2011. Distinct biological effects of different nanoparticles commonly used in cosmetics and medicine coatings. Cell Biosci 1:19-27.