Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers

International Journal of Radiation Biology

Volumn 91, Issue 2, 2015, Pages 142-149

  Lee, Younghyun ^a   Kim, Yang Jee ^a,b   Choi, Young Joo ^a   Lee, Joong Won ^a   Lee, Sunyeong ^a   Cho, Yoon Hee ^c   Chung, Hai Won ^a  

^a Seoul National University   (South Korea)

^b Chung Ang University   (South Korea)

^c UNIVERSITY OF MONTANA   (United States)

Author keywords

Chromosome aberrations; DNA methylation; Nuclear power plant workers; Radiation

Indexed keywords

BISULFITE; DNA; GENOMIC DNA;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BLOOD ANALYSIS; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; DNA STRUCTURE; HUMAN; LONG INTERSPERSED NUCLEAR ELEMENT 1; LOW ENERGY RADIATION; MAJOR CLINICAL STUDY; MALE; NUCLEAR POWER PLANT; NUCLEAR POWER PLANT WORKER; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; REAL TIME POLYMERASE CHAIN REACTION; SMOKING; WORKER; ADVERSE EFFECTS; AGED; CASE CONTROL STUDY; GENETICS; MIDDLE AGED; NUCLEOTIDE REPEAT; RADIATION RESPONSE;

ADULT; AGED; CASE-CONTROL STUDIES; CHROMOSOME ABERRATIONS; DNA METHYLATION; HUMANS; MALE; MIDDLE AGED; NUCLEAR POWER PLANTS; OCCUPATIONAL EXPOSURE; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 84922895898     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2015.969847     Document Type: Article

References (46)

1. Agrawala PK, Adhikari JS, Chaudhury NK. 2010. Lymphocyte chromosomal aberration assay in radiation biodosimetry. J Pharm Bioallied Sci 2 : 197-201
2. Aypar U, Morgan WF, Baulch JE. 2011a. Radiation-induced epigenetic alterations after low and high LET irradiations. Mutat Res 707 : 24-33
3. Aypar U, Morgan WF, Baulch JE. 2011b. Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?. Int J Radiat Biol 87: 179-191
4. Baccarelli A, Bollati V. 2009. Epigenetics and environmental chemicals. Curr Opin Pediatr 21 : 243-251
5. Baylin SB. 2005. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2(SUPPL 1): S4-11
6. Bernal AJ, Dolinoy DC, Huang D, Skaar DA, Weinhouse C, Jirtle RL. 2013. Adaptive radiation-induced epigenetic alterations mitigated by antioxidants. FASEB J 27 : 665-671
7. Cann KL, Dellaire G. 2011. Heterochromatin and the DNA damage response: Th e need to relax. Biochem Cell Biol 89 : 45-60
8. Chalitchagorn K, Shuangshoti S, Hourpai N, Kongruttanachok N , Tangkijvanich P, Th ong-ngam D, Voravud N, Sriuranpong V , Mutirangura A. 2004. Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene 23 : 8841-8846
9. Eden A, Gaudet F, Waghmare A, Jaenisch R. 2003. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300 : 455
10. Elliott AC, Hynan LS. 2011. A SAS(macro implementation of a multiple comparison post hoc test for a Kruskal-Wallis analysis. Comput Methods Programs Biomed 102: 75-80
11. Estécio MR, Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, Jelinek J, Yang AS, Yan PS, Huang TH, Tajara EH, Issa JP. 2007. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. Plos One 2: e399
12. Falk M, LukásováE, Kozubek S. 2008. Chromatin structure infl uences the sensitivity of DNA to gamma-radiation. Biochim Biophys Acta 1783 : 2398-2414
13. Fang X, Corrales J, Th ornton C, Scheffler BE, Willett KL. 2013. Global and gene specifi c DNA methylation changes during zebrafish development. Comp Biochem Physiol B Biochem Mol Biol 166: 99-108
14. Fernàndez-Roig S, Lai SC, Murphy MM, Fernandez-Ballart J , Quadros EV. 2012. Vitamin B12 defi ciency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse, Nutr Metab (Lond) 9 : 41
15. Gehring M, Reik W, Henikoff S. 2009. DNA demethylation by DNA repair. Trends Genet 25 : 82-90
16. Goetz W, Morgan MN, Baulch JE. 2011. Th e eff ect of radiation quality on genomic DNA methylation profi les in irradiated human cell lines. Radiat Res 175: 575-587
17. Hattermann K, Mehdorn HM, Mentlein R, Schultka S, Held-Feindt J. 2008. A methylation-specifi c and SYBR-green-based quantitative polymerase chain reaction technique for O 6 -methylguanine DNA methyltransferase promoter methylation analysis. Anal Biochem 377 : 62-71
18. International Atomic Energy Agency (IAEA). 2011. Cytogenetic dosimetry: Applications in preparedness for and response to radiation emergencies. Vienna: IAEA
19. Jones PA, Baylin SB. 2007. Th e epigenomics of cancer. Cell 128: 683-692
20. Kaup S, Grandjean V, Mukherjee R, Kapoor A, Keyes E, Seymour CB , Mothersill CE, Schofi eld PN. 2006. Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes. Mutat Res 597: 87-97
21. Koturbash I, Pogribny I, Kovalchuk O. 2005. Stable loss of global DNA methylation in the radiation-Target tissue-A possible mechanism contributing to radiation carcinogenesis?. Biochem Biophys Res Commun 337 : 526-533
22. Kovalchuk O, Burke P, Arkhipov A, Kuchma N, James SJ, Kovalchuk I , Pogribny I. 2003. Genome hypermethylation in Pinus silvestris of Chernobyl-A mechanism for radiation adaptation?. Mutat Res 529 : 13-20
23. Kovalchuk O, Burke P, Besplug J, Slovack M, Filkowski J, Pogribny I. 2004. Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-rayirradiation. Mutat Res 548: 75-84
24. Kumar A, Rai PS, Upadhya R, Vishwanatha, Prasada KS, Rao BS , Satyamoorthy K. 2011. Radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. Int J Radiat Biol 87 : 1086-1096
25. Li H, Hilmarsen HT, Hossain MB, Bj ö rk J, Hansteen IL, Albin M , Furu Skjelbred C, Broberg K. 2013. Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood. Genes Chromosomes Cancer 52 : 1-10
26. Ma S, Liu X, Jiao B, Yang Y, Liu X. 2010. Low-dose radiation-induced responses: Focusing on epigenetic regulation. Int J Radiat Biol 86 : 517-528
27. Martínez JG, P érez-Escuredo J, Castro-Santos P, Marcos CA, Pendás JL , Fraga MF, Hermsen MA. 2012. Hypomethylation of LINE-1, and not centromeric SAT- is associated with centromeric instability in head and neck squamous cell carcinoma. Cell Oncol (Dordr) 35: 259-267
28. Moskalev EA, Zavgorodnij MG, Majorova SP, Vorobjev IA, Jandaghi P , Bure IV, Hoheisel JD. 2011. Correction of PCR-bias in quantitative DNA methylation studies by means of cubic polynomial regression. Nucleic Acids Res 39: e77
29. Palii SS, Van Emburgh BO, Sankpal UT, Brown KD, Robertson KD. 2008. DNA methylation inhibitor 5-Aza-2 ' -deoxycytidine induces reversible genome-wide DNA damage that is distinctly infl uenced by DNA methyltransferases 1 and 3B. Mol Cell Biol 28 : 752-771
30. Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK , Ahmad S, White CW. 2004. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antioxid Redox Signal 6: 129-136
31. Pfeiff er P, Goedecke W, Obe G. 2000. Mechanisms of DNA doublestrand break repair and their potential to induce chromosomal aberrations. Mutagenesis 15: 289-302
32. Pogribny I, Koturbash I, Tryndyak V, Hudson D, Stevenson SM, Sedelnikova O, Bonner W, Kovalchuk O. 2005. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol Cancer Res 3: 553-561
33. Pogribny I, Raiche J, Slovack M, Kovalchuk O. 2004. Dose-dependence, sex- And tissue-specifi city, and persistence of radiation-induced genomic DNA methylation changes. Biochem Biophys Res Commun 320 : 1253-1261
34. Raiche J, Rodriguez-Juarez R, Pogribny I, Kovalchuk O. 2004. Sex- And tissue-specifi c expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice. Biochem Biophys Res Commun 325: 39-47
35. Robertson KD. 2002. DNA methylation and chromatin-unraveling the tangled web. Oncogene 21 : 5361-5379
36. Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, Moreno V, Esteller M, Capellà G, Ribas M, Peinado MA. 2006. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res 66 : 8462-9468
37. Rü be CE, Lorat Y, Schuler N, Schanz S, Wennemuth G, Rü be C. 2011. DNA repair in the context of chromatin: New molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. DNA Repair (Amst) 10 : 427-437
38. Schecter A, Malik-Bass N, Calafat AM, Kato K, Colacino JA, Gent TL , Hynan LS, Harris TR, Malla S, Birnbaum L. 2012. Polyfl uoroalkyl compounds in Texas children from birth through 12 years of age. Environ Health Perspect 120: 590-594
39. Shames DS, Minna JD, Gazdar AF. 2007. DNA methylation in health, disease, and cancer. Curr Mol Med 7: 85-102
40. Warnecke PM, Stirzaker C, Melki JR, Millar DS, Paul CL, Clark SJ. 1997. Detection and measurement of PCR bias in quantitative methylation analysis of bisulfi te-Treated DNA. Nucleic Acids Res 25 : 4422-4426
41. Weber M, Schü beler D. 2007. Genomic patterns of DNA methylation: Targets and function of an epigenetic mark. Curr Opin Cell Biol 19 : 273-280
42. Weidman JR, Dolinoy DC, Murphy SK, Jirtle RL. 2007. Cancer susceptibility: Epigenetic manifestation of environmental exposures. Cancer J 13 : 9-16
43. Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, Fiala E, Ehrlich M, Laird PW. 2005. Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res 33: 6823-6836
44. Wojcik A, Gregoire E, Hayata I, Roy L, Sommer S, Stephan G, Voisin P. 2004. Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: A review of three recent radiation accidents. Cytogenet Genome Res 104: 200-205
45. Yang AS, Estécio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. 2004. A simple method for estimating global DNA methylation using bisulfi te PCR of repetitive DNA elements. Nucleic Acids Res 32 : e38
46. Ye S, Yuan D, Xie Y, Pan Y, Shao C. 2013. Role of DNA methylation in long-Term low-dose gamma-rays induced adaptive response in human B lymphoblast cells. Int J Radiat Biol 89: 898-906