Monocyte-derived fibrocytes induce an inflammatory phenotype in airway smooth muscle cells

Clinical and Experimental Allergy

Volumn 44, Issue 11, 2014, Pages 1347-1360

  Lin, T Y ^a,b   Venkatesan, N ^a   Nishioka, M ^a   Kyoh, S ^a   Al Alwan, L ^a   Baglole, C J ^a   Eidelman, D H ^a   Ludwig, M S ^a   Hamid, Q ^a  

^a MCGILL UNIVERSITY   (Canada)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Airway smooth muscle cells; Asthma; Fibrocytes; Inflammation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BRONCHODILATING AGENT; CD14 ANTIGEN; COLLAGEN TYPE 1; CORTICOSTEROID; EOTAXIN; INTERLEUKIN 6; INTERLEUKIN 8; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN LIGHT CHAIN KINASE; SALBUTAMOL; SMALL INTERFERING RNA; THYMIDINE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; ACTA2 PROTEIN, HUMAN; ACTIN;

ADULT; AIRWAY SMOOTH MUSCLE CELL; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; CELL COUNT; CELL ISOLATION; CELL PROLIFERATION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROCYTE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MALE; MESENCHYME CELL; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RESPIRATORY TRACT INFLAMMATION; SMOOTH MUSCLE FIBER; BIOSYNTHESIS; CASE CONTROL STUDY; CELL COMMUNICATION; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; SIGNAL TRANSDUCTION;

ACTINS; ADULT; ASTHMA; CASE-CONTROL STUDIES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; COLLAGEN TYPE I; FEMALE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; MONOCYTES; MYOCYTES, SMOOTH MUSCLE; MYOSIN-LIGHT-CHAIN KINASE; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 84922881789     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12421     Document Type: Article

References (49)

1. Halwani R, Al-Muhsen S, Hamid Q. Airway remodeling in asthma. Curr Opin Pharmacol 2010; 10: 236-45.
2. Fixman ED, Stewart A, Martin JG. Basic mechanisms of development of airway structural changes in asthma. Eur Respir J 2007; 29:379-89.
3. Leguillette R, Lauzon AM. Molecular mechanics of smooth muscle contractile proteins in airway hyperresponsiveness and asthma. Proc Am Thorac Soc 2008; 5:40-6.
4. Pepe C, Foley S, Shannon J et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol 2005; 116:544-9.
5. Xia YC, Redhu NS, Moir LM et al. Pro-inflammatory and immunomodulatory functions of airway smooth muscle: emerging concepts. Pulm Pharmacol Ther 2013; 26:64-74.
6. Chung KF. Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation? Eur Respir J 2000; 15:961-8.
7. Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002; 346:1699-705.
8. Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol 2006; 117:1277-84.
9. Woodman L, Siddiqui S, Cruse G et al. Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1. J Immunol 2008; 181:5001-7.
10. Ramos-Barbon D, Fraga-Iriso R, Brienza NS et al. T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthma. Am J Respir Crit Care Med 2010; 182:317-24.
11. Ramos-Barbon D, Presley JF, Hamid QA, Fixman ED, Martin JG. Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma. J Clin Invest 2005; 115:1580-9.
12. Ammit AJ, Lazaar AL, Irani C et al. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol 2002; 26:465-74.
13. Wuyts WA, Vanaudenaerde BM, Dupont LJ, Demedts MG, Verleden GM. Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1beta-induced chemokine release in human airway smooth muscle cells. Respir Med 2003; 97:811-7.
14. Henness S, van Thoor E, Ge Q, Armour CL, Hughes JM, Ammit AJ. IL-17A acts via p38 MAPK to increase stability of TNF-alpha-induced IL-8 mRNA in human ASM. Am J Physiol Lung Cell Mol Physiol 2006; 290:L1283-90.
15. Xia YC, Harris T, Stewart AG, Mackay GA. Secreted factors from human mast cells trigger inflammatory cytokine production by human airway smooth muscle cells. Int Arch Allergy Immunol 2013; 160:75-85.
16. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992; 89:958-67.
17. Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 2001; 119:1329-36.
18. Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest 2012; 142:86-93.
19. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994; 1:71-81.
20. Saunders R, Siddiqui S, Kaur D et al. Fibrocyte localization to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol 2009; 123:376-84.
21. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 2001; 166:7556-62.
22. Yang L, Scott PG, Giuffre J, Shankowsky HA, Ghahary A, Tredget EE. Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest, 2002; 82:1183-92.
23. Niedermeier M, Reich B, Rodriguez Gomez M et al. CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc Natl Acad Sci U S A 2009; 106:17892-7.
24. Garcia-de-Alba C, Becerril C, Ruiz V et al. Expression of matrix metalloproteases by fibrocytes. Possible role in migration and homing. Am J Respir Crit Care Med 2010; 182:1144-52.
25. Aiba S, Tagami H. Inverse correlation between CD34 expression and proline-4-hydroxylase immunoreactivity on spindle cells noted in hypertrophic scars and keloids. J Cutan Pathol 1997; 24:65-9.
26. Phillips RJ, Burdick MD, Hong K et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004; 114:438-46.
27. Bianchetti L, Barczyk M, Cardoso J, Schmidt M, Bellini A, Mattoli S. Extracellular matrix remodelling properties of human fibrocytes. J Cell Mol Med 2012; 16:483-95.
28. Chesney J, Metz C, Stavitsky AB, Bacher M, Bucala R. Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes. J Immunol 1998; 160:419-25.
29. Wang CH, Huang CD, Lin HC et al. Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am J Respir Crit Care Med 2008; 178:583-91.
30. Nihlberg K, Larsen K, Hultgardh-Nilsson A, Malmstrom A, Bjermer L, Westergren-Thorsson G. Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane? Respir Res 2006; 7:50.
31. Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol 2012; 5:140-9.
32. Varcoe RL, Mikhail M, Guiffre AK et al. The role of the fibrocyte in intimal hyperplasia. J Thromb Haemost 2006; 4:1125-33.
33. Pilling D, Fan T, Huang D, Kaul B, Gomer RH. Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS ONE 2009; 4:e7475.
34. Moore WC, Meyers DA, Wenzel SE et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181:315-23.
35. McGrath KW, Icitovic N, Boushey HA et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med 2012; 185:612-9.
36. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009; 361:888-98.
37. Shaw DE, Berry MA, Hargadon B et al. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest 2007; 132:1871-5.
38. Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D. Pivotal advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol 2008; 83:1323-33.
39. Reilkoff RA, Bucala R, Herzog EL. Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol 2011; 11:427-35.
40. Curnow SJ, Fairclough M, Schmutz C et al. Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum. PLoS ONE 2010; 5:e9730.
41. Reich B, Schmidbauer K, Rodriguez Gomez M et al. Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model. Kidney Int 2013; 84:78-89.
42. Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 2004; 36:598-606.
43. Girodet PO, Ozier A, Trian T et al. Mast cell adhesion to bronchial smooth muscle in asthma specifically depends on CD51 and CD44 variant 6. Allergy 2010; 65:1004-12.
44. Ozier A, Allard B, Bara I et al. The pivotal role of airway smooth muscle in asthma pathophysiology. J Allergy (Cairo) 2011; 2011:742710.
45. Kaur D, Hollins F, Saunders R et al. Airway smooth muscle proliferation and survival is not modulated by mast cells. Clin Exp Allergy 2010; 40:279-88.
46. Halwani R, Al-Abri J, Beland M et al. CC and CXC chemokines induce airway smooth muscle proliferation and survival. J Immunol 2011; 186:4156-63.
47. Ma X, Cheng Z, Kong H et al. Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. Am J Physiol Lung Cell Mol Physiol 2002; 283:L1181-9.
48. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003; 167:1360-8.
49. Al-Alwan LA, Chang Y, Mogas A et al. Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration. J Immunol 2013; 191:2731-41.