메뉴 건너뛰기




Volumn 308, Issue 4, 2015, Pages G269-G276

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

Author keywords

Alcoholic hepatitis; Cytotoxic T lymphocytes; Degranulation; Natural killer cells; Natural killer group 2 D

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 22; NATURAL KILLER CELL RECEPTOR NKG2D; CD56 ANTIGEN; IFNG PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; KLRK1 PROTEIN, HUMAN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; NCAM1 PROTEIN, HUMAN;

EID: 84922875071     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00200.2014     Document Type: Article
Times cited : (26)

References (51)
  • 1
    • 84922868275 scopus 로고    scopus 로고
    • Lymphocyte reference values) 08.03.2014
    • Aarhus University Hospital. DoCBLrv. http://www.auh.dk/om+auh/afdelinger/klinisk+biokemisk+afdeling/for+sundhedsfaglige/analysefortegnelse/hospital. (Lymphocyte reference values) 08.03.2014.
    • Docblrv
    • Aarhus University Hospital1
  • 2
    • 10344255635 scopus 로고    scopus 로고
    • CD107a as a functional marker for the identification of natural killer cell activity
    • Alter G, Malenfant JM, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods 294: 15-22, 2004.
    • (2004) J Immunol Methods , vol.294 , pp. 15-22
    • Alter, G.1    Malenfant, J.M.2    Altfeld, M.3
  • 3
    • 80051657716 scopus 로고    scopus 로고
    • Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-gamma release
    • Bouzani M, Ok M, McCormick A, Ebel F, Kurzai O, Morton CO, Einsele H, Loeffler J. Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-gamma release. J Immunol 187: 1369-1376, 2011.
    • (2011) J Immunol , vol.187 , pp. 1369-1376
    • Bouzani, M.1    Ok, M.2    McCormick, A.3    Ebel, F.4    Kurzai, O.5    Morton, C.O.6    Einsele, H.7    Loeffler, J.8
  • 7
    • 0002585491 scopus 로고
    • Surgery and portal hypertension. In: The Liver and Portal Hypertension, edited by Child CG
    • Child CG, Turcotte JG. Surgery and portal hypertension. In: The Liver and Portal Hypertension, edited by Child CG. Philadelphia, PA: Saunders, 1964, p. 50-64.
    • (1964) Philadelphia, PA: Saunders , pp. 50-64
    • Child, C.G.1    Turcotte, J.G.2
  • 8
    • 84860543583 scopus 로고    scopus 로고
    • Cirrhosis and mortality risks of biopsy-verified alcoholic pure steatosis and steatohepatitis: A nationwide registry-based study
    • Deleuran T, Gronbaek H, Vilstrup H, Jepsen P. Cirrhosis and mortality risks of biopsy-verified alcoholic pure steatosis and steatohepatitis: a nationwide registry-based study. Alimen Pharmacol Ther 35: 1336-1342, 2012.
    • (2012) Alimen Pharmacol Ther , vol.35 , pp. 1336-1342
    • Deleuran, T.1    Gronbaek, H.2    Vilstrup, H.3    Jepsen, P.4
  • 10
    • 0038427741 scopus 로고    scopus 로고
    • Natural killer cells participate in bacterial clearance during septic peritonitis through interactions with macrophages
    • Godshall CJ, Scott MJ, Burch PT, Peyton JC, Cheadle WG. Natural killer cells participate in bacterial clearance during septic peritonitis through interactions with macrophages. Shock 19: 144-149, 2003.
    • (2003) Shock , vol.19 , pp. 144-149
    • Godshall, C.J.1    Scott, M.J.2    Burch, P.T.3    Peyton, J.C.4    Cheadle, W.G.5
  • 11
    • 0024353639 scopus 로고
    • Cytotoxic effector cells of the immune system
    • Groscurth P. Cytotoxic effector cells of the immune system. Anat Embryol 180: 109-119, 1989.
    • (1989) Anat Embryol , vol.180 , pp. 109-119
    • Groscurth, P.1
  • 12
    • 63349086250 scopus 로고    scopus 로고
    • NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis
    • Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology 49: 940-949, 2009.
    • (2009) Hepatology , vol.49 , pp. 940-949
    • Hou, X.1    Zhou, R.2    Wei, H.3    Sun, R.4    Tian, Z.5
  • 14
    • 3242700529 scopus 로고    scopus 로고
    • Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: Alcohol disregulation of NF-kappaB and STAT3 signaling pathways
    • Jaruga B, Hong F, Kim WH, Sun R, Fan S, Gao B. Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways. Am J Physiol Gastrointest Liver Physiol 287: G471-G479, 2004.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G471-G479
    • Jaruga, B.1    Hong, F.2    Kim, W.H.3    Sun, R.4    Fan, S.5    Gao, B.6
  • 15
    • 37349108815 scopus 로고    scopus 로고
    • Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
    • Jeong WI, Park O, Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 134: 248-258, 2008.
    • (2008) Gastroenterology , vol.134 , pp. 248-258
    • Jeong, W.I.1    Park, O.2    Gao, B.3
  • 19
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
    • Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52: 1291-1300, 2010.
    • (2010) Hepatology , vol.52 , pp. 1291-1300
    • Ki, S.H.1    Park, O.2    Zheng, M.3    Morales-Ibanez, O.4    Kolls, J.K.5    Bataller, R.6    Gao, B.7
  • 20
    • 0036660185 scopus 로고    scopus 로고
    • Trafficking machinery of NKT cells: Shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity
    • Kim CH, Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood 100: 11-16, 2002.
    • (2002) Blood , vol.100 , pp. 11-16
    • Kim, C.H.1    Johnston, B.2    Butcher, E.C.3
  • 22
    • 49749111514 scopus 로고    scopus 로고
    • Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma
    • Kohga K, Takehara T, Tatsumi T, Ohkawa K, Miyagi T, Hiramatsu N, Kanto T, Kasugai T, Katayama K, Kato M, Hayashi N. Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma. Cancer Sci 99: 1643-1649, 2008.
    • (2008) Cancer Sci , vol.99 , pp. 1643-1649
    • Kohga, K.1    Takehara, T.2    Tatsumi, T.3    Ohkawa, K.4    Miyagi, T.5    Hiramatsu, N.6    Kanto, T.7    Kasugai, T.8    Katayama, K.9    Kato, M.10    Hayashi, N.11
  • 23
    • 84885871218 scopus 로고    scopus 로고
    • Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis (Abstract)
    • Kong X, Feng D, Wang H, Hong F, Bertola A, Wang FS, Gao B. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis (Abstract). Hepatology 2: 25744, 2012.
    • (2012) Hepatology , vol.2 , pp. 25744
    • Kong, X.1    Feng, D.2    Wang, H.3    Hong, F.4    Bertola, A.5    Wang, F.S.6    Gao, B.7
  • 24
    • 84867218760 scopus 로고    scopus 로고
    • Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
    • Kramer B, Korner C, Kebschull M, Glassner A, Eisenhardt M, Nischalke HD, Alexander M, Sauerbruch T, Spengler U, Natter-mann J. Natural killer p46High expression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis. Hepatology 56: 1201-1213, 2012.
    • (2012) Hepatology , vol.56 , pp. 1201-1213
    • Kramer, B.1    Korner, C.2    Kebschull, M.3    Glassner, A.4    Eisenhardt, M.5    Nischalke, H.D.6    Alexander, M.7    Sauerbruch, T.8    Spengler, U.9    Natter-Mann, J.10
  • 25
    • 0030991267 scopus 로고    scopus 로고
    • Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption
    • Laso FJ, Madruga JI, Giron JA, Lopez A, Ciudad J, San Miguel JF, Alvarez-Mon M, Orfao A. Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption. Hepatology 25: 1096-1100, 1997.
    • (1997) Hepatology , vol.25 , pp. 1096-1100
    • Laso, F.J.1    Madruga, J.I.2    Giron, J.A.3    Lopez, A.4    Ciudad, J.5    San Miguel, J.F.6    Alvarez-Mon, M.7    Orfao, A.8
  • 26
    • 0030988743 scopus 로고    scopus 로고
    • Abnormalities of peripheral blood T lymphocytes and natural killer cells in alcoholic hepatitis persist after a 3-month withdrawal period
    • Laso FJ, Madruga JI, Lopez A, Ciudad J, Alvarez-Mon M, San Miguel J, Orfao A. Abnormalities of peripheral blood T lymphocytes and natural killer cells in alcoholic hepatitis persist after a 3-month withdrawal period. Alcohol Clin Exp Res 21: 672-676, 1997.
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 672-676
    • Laso, F.J.1    Madruga, J.I.2    Lopez, A.3    Ciudad, J.4    Alvarez-Mon, M.5    San Miguel, J.6    Orfao, A.7
  • 27
    • 79955438684 scopus 로고    scopus 로고
    • Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection (Abstract)
    • Li J, Han Y, Jin K, Wan Y, Wang S, Liu B, Liu Y, Lu S, Huang Z. Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection (Abstract). Virol J 8: 199, 2011.
    • (2011) Virol J , vol.8 , pp. 199
    • Li, J.1    Han, Y.2    Jin, K.3    Wan, Y.4    Wang, S.5    Liu, B.6    Liu, Y.7    Lu, S.8    Huang, Z.9
  • 28
    • 84880838425 scopus 로고    scopus 로고
    • NK cell isolation from liver biopsies: Phenotypic and functional analysis of low cell numbers by flow cytometry (Abstract)
    • Li N, Puga Yung GL, Pradier A, Toso C, Giostra E, Morard I, Spahr L, Seebach JD. NK cell isolation from liver biopsies: phenotypic and functional analysis of low cell numbers by flow cytometry (Abstract). Front Immunol 4: 61, 2013.
    • (2013) Front Immunol , vol.4 , pp. 61
    • Li, N.1    Puga Yung, G.L.2    Pradier, A.3    Toso, C.4    Giostra, E.5    Morard, I.6    Spahr, L.7    Seebach, J.D.8
  • 32
    • 84877050511 scopus 로고    scopus 로고
    • Lymphopenia as risk factor for development of severe infections in patients with systemic lupus erythematosus: A case-control study.
    • Merayo-Chalico J, Gomez-Martin D, Pineirua-Menendez A, Santana De Anda K, Alcocer-Varela J. Lymphopenia as risk factor for development of severe infections in patients with systemic lupus erythematosus: a case-control study. Q J Med 106: 451–457, 2013.
    • (2013) Q J Med , vol.106 , pp. 451-457
    • Merayo-Chalico, J.1    Gomez-Martin, D.2    Pineirua-Menendez, A.3    Santana De Anda, K.4    Alcocer-Varela, J.5
  • 33
    • 2142653007 scopus 로고    scopus 로고
    • Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology
    • Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology 126: 1387–1399, 2004.
    • (2004) , vol.126 , pp. 1387-1399
    • Minagawa, M.1    Deng, Q.2    Liu, Z.X.3    Tsukamoto, H.4    Dennert, G.5
  • 35
    • 67649980706 scopus 로고    scopus 로고
    • Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: Implications for immunity
    • Nath B, Szabo G. Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity. Semin Liver Dis 29: 166-177, 2009.
    • (2009) Semin Liver Dis , vol.29 , pp. 166-177
    • Nath, B.1    Szabo, G.2
  • 37
    • 84908088067 scopus 로고    scopus 로고
    • Short-term and long-term causes of death in patients with alcoholic hepatitis in Denmark
    • Orntoft NW, Sandahl TD, Jepsen P, Vilstrup H. Short-term and long-term causes of death in patients with alcoholic hepatitis in Denmark. Clin Gastroenterol Hepatol 12: 1739-1744, 2014.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1739-1744
    • Orntoft, N.W.1    Sandahl, T.D.2    Jepsen, P.3    Vilstrup, H.4
  • 39
    • 61449115971 scopus 로고    scopus 로고
    • CD56bright natural killer (NK) cells: An important NK cell subset
    • Poli A, Michel T, Theresine M, Andres E, Hentges F, Zimmer J. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 126: 458–465, 2009.
    • (2009) Immunology , vol.126 , pp. 458-465
    • Poli, A.1    Michel, T.2    Theresine, M.3    Res, E.4    Hentges, F.5    Zimmer, J.6
  • 41
    • 32044443617 scopus 로고    scopus 로고
    • Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
    • Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130: 435–452, 2006.
    • (2006) Gastroenterology , vol.130 , pp. 435-452
    • Radaeva, S.1    Sun, R.2    Jaruga, B.3    Nguyen, V.T.4    Tian, Z.5    Gao, B.6
  • 42
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S, Sun R, Pan HN, Hong F, Gao B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39: 1332-1342, 2004.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 44
    • 79952708982 scopus 로고    scopus 로고
    • Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: A nationwide population based cohort study
    • Sandahl TD, Jepsen P, Thomsen KL, Vilstrup H. Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study. J Hepatol 54: 760-764, 2011.
    • (2011) J Hepatol , vol.54 , pp. 760-764
    • Sandahl, T.D.1    Jepsen, P.2    Thomsen, K.L.3    Vilstrup, H.4
  • 46
    • 84872849622 scopus 로고    scopus 로고
    • Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course
    • Stoy S, Sandahl TD, Dige AK, Agnholt J, Rasmussen TK, Gronbaek H, Deleuran B, Vilstrup H. Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course. PloS one 8: e55101, 2013.
    • (2013) Plos One , pp. 8
    • Stoy, S.1    Sandahl, T.D.2    Dige, A.K.3    Agnholt, J.4    Rasmussen, T.K.5    Gronbaek, H.6    Deleuran, B.7    Vilstrup, H.8
  • 47
    • 67649669912 scopus 로고    scopus 로고
    • Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease
    • Tajiri K, Shimizu Y, Tsuneyama K, Sugiyama T. Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol 21: 673-680, 2009.
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , pp. 673-680
    • Tajiri, K.1    Shimizu, Y.2    Tsuneyama, K.3    Sugiyama, T.4
  • 49
    • 36749019143 scopus 로고    scopus 로고
    • Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus
    • Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci USA 104: 18187–18192, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18187-18192
    • Vilarinho, S.1    Ogasawara, K.2    Nishimura, S.3    Lanier, L.L.4    Baron, J.L.5
  • 51
    • 34548674932 scopus 로고    scopus 로고
    • Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease
    • Xu CF, Yu CH, Li YM, Xu L, Du J, Shen Z. Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease. World J Gastroenterol 13: 4504–4508, 2007.
    • (2007) World J Gastroenterol , vol.13 , pp. 4504-4508
    • Xu, C.F.1    Yu, C.H.2    Li, Y.M.3    Xu, L.4    Du, J.5    Shen, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.