Non-alcoholic steatohepatitis weakens the acute phase response to endotoxin in rats

Liver International

Volumn 34, Issue 10, 2014, Pages 1584-1592

  Thomsen, Karen L ^a   Hebbard, Lionel ^b   Glavind, Emilie ^a   Clouston, Andrew ^c   Vilstrup, Hendrik ^a   George, Jacob ^b   Grønbæk, Henning ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Acute phase response; Cytokines; Inflammation; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Rats

Indexed keywords

ACUTE PHASE PROTEIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTOXIN; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; PRIMER DNA;

ACUTE PHASE RESPONSE; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL DIET; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ACTIVITY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; INFECTION SENSITIVITY; LIPID DIET; LIVER BIOPSY; LIVER FIBROSIS; LIVER WEIGHT; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SCORING SYSTEM; SPLEEN WEIGHT; ANIMAL; BLOOD; GENETICS; IMMUNOASSAY; IMMUNOLOGY; LIVER; METABOLISM; NONPARAMETRIC TEST; POLYMERASE CHAIN REACTION; WISTAR RAT;

ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ANIMALS; DNA PRIMERS; ENDOTOXINS; FEMALE; IMMUNOASSAY; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84908121964     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12547     Document Type: Article

References (20)

1. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American association for the study of liver diseases, American college of gastroenterology, and the american gastroenterological association. Am J Gastroenterol 2012; 107: 811-26.
2. Matteoni CA, Younossi ZM, Gramlich T, et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413-9.
3. Jepsen P, Vilstrup H, Mellemkjaer L, et al. Prognosis of patients with a diagnosis of fatty liver-a registry-based cohort study. Hepatogastroenterology 2003; 50: 2101-4.
4. Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44: 865-73.
5. Ceciliani F, Giordano A, Spagnolo V. The systemic reaction during inflammation: the acute-phase proteins. Protein Pept Lett 2002; 9: 211-23.
6. Inzaugarat ME, Ferreyra Solari NE, Billordo LA, et al. Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis. J Clin Immunol 2011; 31: 1120-30.
7. Milland J, Tsykin A, Thomas T, et al. Gene expression in regenerating and acute-phase rat liver. Am J Physiol 1990; 259(3 Pt 1): G340-7.
8. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448-54.
9. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21.
10. Nielsen SS, Grofte T, Tygstrup N, Vilstrup H. Effect of lipopolysaccharide on in vivo and genetic regulation of rat urea synthesis. Liver Int 2005; 25: 177-83.
11. Nielsen SS, Grofte T, Tygstrup N, Vilstrup H. Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide. Comp Hepatol 2006; 5: 3.
12. Xu ZJ, Fan JG, Ding XD, Qiao L, Wang GL. Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats. Dig Dis Sci 2010; 55: 931-40.
13. Treeprasertsuk S, Bjornsson E, Enders F, Suwanwalaikorn S, Lindor KD. NAFLD fibrosis score: a prognostic predictor for mortality and liver complications among NAFLD patients. World J Gastroenterol 2013; 19: 1219-29.
14. Harry D, Anand R, Holt S, et al. Increased sensitivity to endotoxemia in the bile duct-ligated cirrhotic Rat. Hepatology 1999; 30: 1198-205.
15. Imajo K, Fujita K, Yoneda M, et al. Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling. Cell Metab 2012; 16: 44-54.
16. Kudo H, Takahara T, Yata Y, et al. Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. J Hepatol 2009; 51: 168-75.
17. Schreiber G, Tsykin A, Aldred AR, et al. The acute phase response in the rodent. Ann NY Acad Sci 1989; 557: 61-85.
18. Geiger T, Andus T, Klapproth J, et al. Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur J Immunol 1988; 18: 717-21.
19. Jensen SA. Liver gene regulation in rats following both 70 or 90% hepatectomy and endotoxin treatment. J Gastroenterol Hepatol 2001; 16: 525-30.
20. Park WB, Lee KD, Lee CS, et al. Production of C-reactive protein in Escherichia coli-infected patients with liver dysfunction due to liver cirrhosis. Diagn Microbiol Infect Dis 2005; 51: 227-30.