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Volumn 4, Issue MAR, 2013, Pages

NK cell isolation from liver biopsies: Phenotypic and functional analysis of low cell numbers by flow cytometry

Author keywords

CD107a; Collagenase; Flow cytometry; Human NK cells; IFN ; Intrahepatic lymphocytes; Liver biopsy

Indexed keywords

CD16 ANTIGEN; CD56 ANTIGEN; CYTOKINE; DEOXYRIBONUCLEASE I; GAMMA INTERFERON; GELATINASE A; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1;

EID: 84880838425     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00061     Document Type: Article
Times cited : (14)

References (44)
  • 1
    • 0030583236 scopus 로고    scopus 로고
    • Collagenase and Dispase enzymes disrupt lymphocyte surface molecules
    • Abuzakouk, M., Feighery, C., and O'Farrelly, C. (1996). Collagenase and Dispase enzymes disrupt lymphocyte surface molecules. J. Immunol. Methods 194, 211-216.
    • (1996) J. Immunol. Methods , vol.194 , pp. 211-216
    • Abuzakouk, M.1    Feighery, C.2    O'Farrelly, C.3
  • 2
    • 72549104093 scopus 로고    scopus 로고
    • Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner
    • Ahlenstiel, G., Titerence, R. H., Koh, C., Edlich, B., Feld, J. J., Rotman, Y., et al. (2010). Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology 138, 325-335. e321-e322.
    • (2010) Gastroenterology , vol.138
    • Ahlenstiel, G.1    Titerence, R.H.2    Koh, C.3    Edlich, B.4    Feld, J.J.5    Rotman, Y.6
  • 3
    • 57349092199 scopus 로고    scopus 로고
    • Relationship between CD107a expression and cytotoxic activity
    • Aktas, E., Kucuksezer, U. C., Bilgic, S., Erten, G., and Deniz, G. (2009). Relationship between CD107a expression and cytotoxic activity. Cell. Immunol. 254, 149-154.
    • (2009) Cell. Immunol. , vol.254 , pp. 149-154
    • Aktas, E.1    Kucuksezer, U.C.2    Bilgic, S.3    Erten, G.4    Deniz, G.5
  • 4
    • 10344255635 scopus 로고    scopus 로고
    • CD107a as a functional marker for the identification of natural killer cell activity
    • Alter, G., Malenfant, J. M., and Altfeld, M. (2004). CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods 294, 15-22.
    • (2004) J. Immunol. Methods , vol.294 , pp. 15-22
    • Alter, G.1    Malenfant, J.M.2    Altfeld, M.3
  • 5
    • 0036841051 scopus 로고    scopus 로고
    • Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease
    • Apolinario, A., Majano, P. L., Alvarez-Perez, E., Saez, A., Lozano, C., Vargas, J., et al. (2002). Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Am. J. Gastroenterol. 97, 2861-2870.
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 2861-2870
    • Apolinario, A.1    Majano, P.L.2    Alvarez-Perez, E.3    Saez, A.4    Lozano, C.5    Vargas, J.6
  • 6
    • 58149311010 scopus 로고    scopus 로고
    • Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained
    • Blom, K. G., Qazi, M. R., Matos, J. B., Nelson, B. D., Depierre, J. W., and Abedi-Valugerdi, M. (2009). Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained. Clin. Exp. Immunol. 155, 320-329.
    • (2009) Clin. Exp. Immunol. , vol.155 , pp. 320-329
    • Blom, K.G.1    Qazi, M.R.2    Matos, J.B.3    Nelson, B.D.4    Depierre, J.W.5    Abedi-Valugerdi, M.6
  • 7
    • 68049142973 scopus 로고    scopus 로고
    • Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C
    • Bonorino, P., Ramzan, M., Camous, X., Dufeu-Duchesne, T., Thelu, M. A., Sturm, N., et al. (2009). Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C. J. Hepatol. 51, 458-467.
    • (2009) J. Hepatol. , vol.51 , pp. 458-467
    • Bonorino, P.1    Ramzan, M.2    Camous, X.3    Dufeu-Duchesne, T.4    Thelu, M.A.5    Sturm, N.6
  • 10
    • 67650750880 scopus 로고    scopus 로고
    • The liver as a lymphoid organ
    • Crispe, I. N. (2009). The liver as a lymphoid organ. Annu. Rev. Immunol. 27, 147-163.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 147-163
    • Crispe, I.N.1
  • 11
    • 0034726404 scopus 로고    scopus 로고
    • Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization
    • Curry, M. P., Norris, S., Golden-Mason, L., Doherty, D. G., Deignan, T., Collins, C., et al. (2000). Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization. J. Immunol. Methods 242, 21-31.
    • (2000) J. Immunol. Methods , vol.242 , pp. 21-31
    • Curry, M.P.1    Norris, S.2    Golden-Mason, L.3    Doherty, D.G.4    Deignan, T.5    Collins, C.6
  • 12
    • 77649184029 scopus 로고    scopus 로고
    • Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: reversion by anti-viral treatment
    • Dessouki, O., Kamiya, Y., Nagahama, H., Tanaka, M., Suzu, S., Sasaki, Y., et al. (2010). Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: reversion by anti-viral treatment. Biochem. Biophys. Res. Commun. 393, 331-337.
    • (2010) Biochem. Biophys. Res. Commun. , vol.393 , pp. 331-337
    • Dessouki, O.1    Kamiya, Y.2    Nagahama, H.3    Tanaka, M.4    Suzu, S.5    Sasaki, Y.6
  • 13
    • 0033566963 scopus 로고    scopus 로고
    • The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns
    • Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., et al. (1999). The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J. Immunol. 163, 2314-2321.
    • (1999) J. Immunol. , vol.163 , pp. 2314-2321
    • Doherty, D.G.1    Norris, S.2    Madrigal-Estebas, L.3    McEntee, G.4    Traynor, O.5    Hegarty, J.E.6
  • 14
    • 0034113629 scopus 로고    scopus 로고
    • Innate and adaptive lymphoid cells in the human liver
    • Doherty, D. G., and O'Farrelly, C. (2000). Innate and adaptive lymphoid cells in the human liver. Immunol. Rev. 174, 5-20.
    • (2000) Immunol. Rev. , vol.174 , pp. 5-20
    • Doherty, D.G.1    O'Farrelly, C.2
  • 15
    • 33947411395 scopus 로고    scopus 로고
    • Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage
    • Dunn, C., Brunetto, M., Reynolds, G., Christophides, T., Kennedy, P. T., Lampertico, P., et al. (2007). Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J. Exp. Med. 204, 667-680.
    • (2007) J. Exp. Med. , vol.204 , pp. 667-680
    • Dunn, C.1    Brunetto, M.2    Reynolds, G.3    Christophides, T.4    Kennedy, P.T.5    Lampertico, P.6
  • 16
    • 84863615340 scopus 로고    scopus 로고
    • The CXCR3(+)CD56bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C
    • doi:10.1371/journal.pone.0038846
    • Eisenhardt, M., Glassner, A., Kramer, B., Korner, C., Sibbing, B., Kokordelis, P., et al. (2012). The CXCR3(+)CD56bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C. PLoS ONE 7:e38846. doi:10.1371/journal.pone.0038846
    • (2012) PLoS ONE , vol.7
    • Eisenhardt, M.1    Glassner, A.2    Kramer, B.3    Korner, C.4    Sibbing, B.5    Kokordelis, P.6
  • 17
    • 0032780473 scopus 로고    scopus 로고
    • Optimisation of a technique for isolating lymphocyte subsets from human endometrium
    • Flynn, L, Carton, J., Byrne, B., Kelehan, P., O'Herlihy, C., and O'Farrelly, C. (1999). Optimisation of a technique for isolating lymphocyte subsets from human endometrium. Immunol. Invest. 28, 235-246.
    • (1999) Immunol. Invest. , vol.28 , pp. 235-246
    • Flynn, L.1    Carton, J.2    Byrne, B.3    Kelehan, P.4    O'Herlihy, C.5    O'Farrelly, C.6
  • 18
    • 39549097751 scopus 로고    scopus 로고
    • Liver: an organ with predominant innate immunity
    • Gao, B., Jeong, W. I., and Tian, Z. (2008). Liver: an organ with predominant innate immunity. Hepatology 47, 729-736.
    • (2008) Hepatology , vol.47 , pp. 729-736
    • Gao, B.1    Jeong, W.I.2    Tian, Z.3
  • 19
    • 77958154113 scopus 로고    scopus 로고
    • CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation
    • Hintermann, E., Bayer, M., Pfeilschifter, J. M., Luster, A. D., and Christen, U. (2010). CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. J. Autoimmun. 35, 424-435.
    • (2010) J. Autoimmun. , vol.35 , pp. 424-435
    • Hintermann, E.1    Bayer, M.2    Pfeilschifter, J.M.3    Luster, A.D.4    Christen, U.5
  • 20
    • 33644517272 scopus 로고    scopus 로고
    • Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans
    • Ishiyama, K., Ohdan, H., Ohira, M., Mitsuta, H., Arihiro, K., and Asahara, T. (2006). Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans. Hepatology 43, 362-372.
    • (2006) Hepatology , vol.43 , pp. 362-372
    • Ishiyama, K.1    Ohdan, H.2    Ohira, M.3    Mitsuta, H.4    Arihiro, K.5    Asahara, T.6
  • 21
    • 33845625311 scopus 로고    scopus 로고
    • Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities
    • Jinushi, M., Takehara, T., Tatsumi, T., Yamaguchi, S., Sakamori, R., Hiramatsu, N., et al. (2007). Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities. Immunology 120, 73-82.
    • (2007) Immunology , vol.120 , pp. 73-82
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Yamaguchi, S.4    Sakamori, R.5    Hiramatsu, N.6
  • 22
    • 0033759170 scopus 로고    scopus 로고
    • Decrease of CD56(+) T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma
    • Kawarabayashi, N., Seki, S., Hatsuse, K., Ohkawa, T., Koike, Y., Aihara, T., et al. (2000). Decrease of CD56(+) T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma. Hepatology 32, 962-969.
    • (2000) Hepatology , vol.32 , pp. 962-969
    • Kawarabayashi, N.1    Seki, S.2    Hatsuse, K.3    Ohkawa, T.4    Koike, Y.5    Aihara, T.6
  • 23
    • 84867218760 scopus 로고    scopus 로고
    • NKp46 (High) expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis
    • Kramer, B., Korner, C., Kebschull, M., Glassner, A., Eisenhardt, M., Nischalke, H. D., et al. (2012). NKp46 (High) expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis. Hepatology 56, 1201-1213.
    • (2012) Hepatology , vol.56 , pp. 1201-1213
    • Kramer, B.1    Korner, C.2    Kebschull, M.3    Glassner, A.4    Eisenhardt, M.5    Nischalke, H.D.6
  • 24
    • 79955657127 scopus 로고    scopus 로고
    • Regulation of NK cell repertoire and function in the liver
    • Krueger, P. D., Lassen, M. G., Qiao, H., and Hahn, Y. S. (2011). Regulation of NK cell repertoire and function in the liver. Crit. Rev. Immunol. 31, 43-52.
    • (2011) Crit. Rev. Immunol. , vol.31 , pp. 43-52
    • Krueger, P.D.1    Lassen, M.G.2    Qiao, H.3    Hahn, Y.S.4
  • 25
    • 0022589079 scopus 로고
    • The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes
    • Lanier, L. L., Le, A. M., Civin, C. I., Loken, M. R., and Phillips, J. H. (1986). The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J. Immunol. 136, 4480-4486.
    • (1986) J. Immunol. , vol.136 , pp. 4480-4486
    • Lanier, L.L.1    Le, A.M.2    Civin, C.I.3    Loken, M.R.4    Phillips, J.H.5
  • 26
    • 34347257433 scopus 로고    scopus 로고
    • Liver biopsy assessment in chronic hepatitis
    • Lefkowitch, J. H. (2007). Liver biopsy assessment in chronic hepatitis. Arch. Med. Res. 38, 634-643.
    • (2007) Arch. Med. Res. , vol.38 , pp. 634-643
    • Lefkowitch, J.H.1
  • 27
    • 25144472170 scopus 로고    scopus 로고
    • Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections
    • Meier, U. C., Owen, R. E., Taylor, E., Worth, A., Naoumov, N., Willberg, C., et al. (2005). Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections. J. Virol. 79, 12365-12374.
    • (2005) J. Virol. , vol.79 , pp. 12365-12374
    • Meier, U.C.1    Owen, R.E.2    Taylor, E.3    Worth, A.4    Naoumov, N.5    Willberg, C.6
  • 28
    • 77955464771 scopus 로고    scopus 로고
    • Natural killer cells in viral hepatitis: facts and controversies
    • Mondelli, M. U., Varchetta, S., and Oliviero, B. (2010). Natural killer cells in viral hepatitis: facts and controversies. Eur. J. Clin. Invest. 40, 851-863.
    • (2010) Eur. J. Clin. Invest. , vol.40 , pp. 851-863
    • Mondelli, M.U.1    Varchetta, S.2    Oliviero, B.3
  • 29
    • 13444262017 scopus 로고    scopus 로고
    • Isolation, purification and flow cytometric analysis of human intrahepatic lymphocytes using an improved technique
    • Morsy, M. A., Norman, P. J., Mitry, R., Rela, M., Heaton, N. D., and Vaughan, R. W. (2005). Isolation, purification and flow cytometric analysis of human intrahepatic lymphocytes using an improved technique. Lab. Invest. 85, 285-296.
    • (2005) Lab. Invest. , vol.85 , pp. 285-296
    • Morsy, M.A.1    Norman, P.J.2    Mitry, R.3    Rela, M.4    Heaton, N.D.5    Vaughan, R.W.6
  • 31
    • 73949158484 scopus 로고    scopus 로고
    • Non-viral-related pathologic findings in liver needle biopsy specimens from patients with chronic viral hepatitis
    • Nair, V., Fischer, S. E., and Adeyi, O. A. (2010). Non-viral-related pathologic findings in liver needle biopsy specimens from patients with chronic viral hepatitis. Am. J. Clin. Pathol. 133, 127-132.
    • (2010) Am. J. Clin. Pathol. , vol.133 , pp. 127-132
    • Nair, V.1    Fischer, S.E.2    Adeyi, O.A.3
  • 32
    • 33646810822 scopus 로고    scopus 로고
    • Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C
    • Nattermann, J., Feldmann, G., Ahlenstiel, G., Langhans, B., Sauerbruch, T., and Spengler, U. (2006). Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut 55, 869-877.
    • (2006) Gut , vol.55 , pp. 869-877
    • Nattermann, J.1    Feldmann, G.2    Ahlenstiel, G.3    Langhans, B.4    Sauerbruch, T.5    Spengler, U.6
  • 33
    • 13244257273 scopus 로고    scopus 로고
    • The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells
    • Nattermann, J., Nischalke, H. D., Hofmeister, V., Ahlenstiel, G., Zimmermann, H., Leifeld, L., et al. (2005). The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells. Am. J. Pathol. 166, 443-453.
    • (2005) Am. J. Pathol. , vol.166 , pp. 443-453
    • Nattermann, J.1    Nischalke, H.D.2    Hofmeister, V.3    Ahlenstiel, G.4    Zimmermann, H.5    Leifeld, L.6
  • 34
    • 0031937330 scopus 로고    scopus 로고
    • Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes
    • Norris, S., Collins, C., Doherty, D. G., Smith, F., McEntee, G., Traynor, O., et al. (1998). Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. J. Hepatol. 28, 84-90.
    • (1998) J. Hepatol. , vol.28 , pp. 84-90
    • Norris, S.1    Collins, C.2    Doherty, D.G.3    Smith, F.4    McEntee, G.5    Traynor, O.6
  • 35
    • 0028038287 scopus 로고
    • Flow cytometry CD4+/CD8+ ratio of liver-derived lymphocytes correlates with viral replication in chronic hepatitis B
    • Pham, B. N., Mosnier, J. F., Walker, F., Njapoum, C., Bougy, F., Degott, C., et al. (1994). Flow cytometry CD4+/CD8+ ratio of liver-derived lymphocytes correlates with viral replication in chronic hepatitis B. Clin. Exp. Immunol. 97, 403-410.
    • (1994) Clin. Exp. Immunol. , vol.97 , pp. 403-410
    • Pham, B.N.1    Mosnier, J.F.2    Walker, F.3    Njapoum, C.4    Bougy, F.5    Degott, C.6
  • 37
    • 67649669912 scopus 로고    scopus 로고
    • Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease
    • Tajiri, K., Shimizu, Y., Tsuneyama, K., and Sugiyama, T. (2009). Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease. Eur. J. Gastroenterol. Hepatol. 21, 673-680.
    • (2009) Eur. J. Gastroenterol. Hepatol. , vol.21 , pp. 673-680
    • Tajiri, K.1    Shimizu, Y.2    Tsuneyama, K.3    Sugiyama, T.4
  • 38
    • 84876114251 scopus 로고    scopus 로고
    • Natural killer cells in liver disease
    • doi:10.1002/hep.26115. [Epub ahead of print]
    • Tian, Z., Chen, Y., and Gao, B. (2012). Natural killer cells in liver disease. Hepatology. doi:10.1002/hep.26115. [Epub ahead of print].
    • (2012) Hepatology
    • Tian, Z.1    Chen, Y.2    Gao, B.3
  • 39
    • 6844258183 scopus 로고    scopus 로고
    • Phenotyping of intrahepatic and peripheral blood lymphocytes in patients with chronic hepatitis C
    • Tran, A, Yang, G., Doglio, A., Ticchioni, M., Laffont, C., Durant, J., et al. (1997). Phenotyping of intrahepatic and peripheral blood lymphocytes in patients with chronic hepatitis C. Dig. Dis. Sci. 42, 2495-2500.
    • (1997) Dig. Dis. Sci. , vol.42 , pp. 2495-2500
    • Tran, A.1    Yang, G.2    Doglio, A.3    Ticchioni, M.4    Laffont, C.5    Durant, J.6
  • 40
    • 18644363090 scopus 로고    scopus 로고
    • The CD107 mobilization assay: viable isolation and immunotherapeutic potential of tumor-cytolytic NK cells
    • Uhrberg, M. (2005). The CD107 mobilization assay: viable isolation and immunotherapeutic potential of tumor-cytolytic NK cells. Leukemia 19, 707-709.
    • (2005) Leukemia , vol.19 , pp. 707-709
    • Uhrberg, M.1
  • 41
    • 84865542942 scopus 로고    scopus 로고
    • Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection
    • Varchetta, S., Mele, D., Mantovani, S., Oliviero, B., Cremonesi, E., Ludovisi, S., et al. (2012). Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection. Hepatology 56, 841-849.
    • (2012) Hepatology , vol.56 , pp. 841-849
    • Varchetta, S.1    Mele, D.2    Mantovani, S.3    Oliviero, B.4    Cremonesi, E.5    Ludovisi, S.6
  • 42
    • 62949166560 scopus 로고    scopus 로고
    • Natural killer cell receptors and their ligands in liver diseases
    • Yamagiwa, S., Kamimura, H., and Ichida, T. (2009). Natural killer cell receptors and their ligands in liver diseases. Med. Mol. Morphol. 42, 1-8.
    • (2009) Med. Mol. Morphol. , vol.42 , pp. 1-8
    • Yamagiwa, S.1    Kamimura, H.2    Ichida, T.3
  • 43
    • 44649145310 scopus 로고    scopus 로고
    • Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells
    • Yamagiwa, S., Matsuda, Y., Ichida, T., Honda, Y., Takamura, M., Sugahara, S., et al. (2008). Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells. Hepatol. Res. 38, 664-672.
    • (2008) Hepatol. Res. , vol.38 , pp. 664-672
    • Yamagiwa, S.1    Matsuda, Y.2    Ichida, T.3    Honda, Y.4    Takamura, M.5    Sugahara, S.6
  • 44
    • 78751482977 scopus 로고    scopus 로고
    • Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients
    • Zhang, Z., Zhang, S., Zou, Z., Shi, J., Zhao, J., Fan, R., et al. (2011). Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients. Hepatology 53, 73-85.
    • (2011) Hepatology , vol.53 , pp. 73-85
    • Zhang, Z.1    Zhang, S.2    Zou, Z.3    Shi, J.4    Zhao, J.5    Fan, R.6


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