Distribution and clinical significance of tumour-associated macrophages in pancreatic ductal adenocarcinoma: A retrospective analysis in China

Current Oncology

Volumn 22, Issue 1, 2015, Pages e11-e19

  Chen, S J ^a,b   Zhang, Q B ^c   Zeng, L J ^d   Lian, G D ^a,b   Li, J J ^a,b   Qian, C C ^a,b   Chen, Y Z ^a,b   Chen, Y T ^a,b   Huang, K H ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c Li Huili Hospital of Ningbo Medical Center   (China)

^d THE FIFTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Lymph node metastasis; Neural invasion; Pancreatic cancer; Tumour associated macrophages

Indexed keywords

CD163 ANTIGEN; CD68 ANTIGEN;

ABDOMINAL PAIN; ADULT; AGE; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CELL COUNT; CELL DIFFERENTIATION; CELL INFILTRATION; CELL INVASION; CHEMOTHERAPY; CHINA; CHRONIC PANCREATITIS; CLINICAL FEATURE; DATA ANALYSIS; FEMALE; GENDER; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PATHOLOGY; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SURVIVAL RATE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR LOCALIZATION; TUMOR VOLUME; VERY ELDERLY;

EID: 84922843084     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.22.2150     Document Type: Article

References (42)

1. Raraty MG, Magee CJ, Ghaneh P, Neoptolemos JP. New techniques and agents in the adjuvant therapy of pancreatic cancer. Acta Oncol 2002;41:582–95.
2. Beger HG, Rau B, Gansauge F, Poch B, Link KH. Treatment of pancreatic cancer: challenge of the facts. World J Surg 2003;27:1075–84.
3. Niederhuber JE, Brennan MF, Menck HR. The national cancer data base report on pancreatic cancer. Cancer 1995;76:1671–7.
4. Lowenfels AB, Maisonneuve P, Cavallini G, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 1993;328:1433–7.
5. Gress TM, Wallrapp C, Frohme M, et al. Identification of genes with specific expression in pancreatic cancer by cdna representational difference analysis. Genes Chromosomes Cancer 1997;19:97–103.
6. Gress TM, Muller–Pillasch F, Geng M, et al. A pancreaticcan -cer–specifc expression profile. Oncogene 1996;13:1819–30.
7. Geng M, Wallrapp C, Müller–Pillasch F, Frohme M, Hoheisel JD, Gress TM. Isolation of differentially expressed genes by combining representational difference analysis (rda) and cdna library arrays. Biotechniques 1998;25:434–8.
8. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.
9. Allavena P, Sica A, Garlanda C, Mantovani A. The yin–yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev 2008;222:155–61.
10. Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (tam) as major players of the cancer-related infammation. J Leukoc Biol 2009;86:1065–73.
11. Kurahara H, Shinchi H, Mataki Y, et al. Significance of M2-polarized tumor-associated macrophage in pancreatic cancer. J Surg Res 2011; 167:e211–19.
12. Kurahara H, Takao S, Maemura K, et al. M2-Polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer. Pancreas 2013;42:155–9.
13. Ayari C, LaRue H, Hovington H, et al. Bladder tumor infiltrating mature dendritic cells and macrophages as predictors of response to bacillus Calmette–Guérin immunotherapy. Eur Urol 2009;55:1386–95.
14. Cui YL, Li HK, Zhou HY, Zhang T, Li Q. Correlations of t u mor-associated macrophage subtypes with liver metastases of colorectal cancer. Asian Pac J Cancer Prev 2013;14:1003–7.
15. Herwig MC, Bergstrom C, Wells JR, Holler T, Grossniklaus HE. M2/M1 Ratio of tumor associated macrophages and ppar-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles. Exp Eye Res 2013;107:52–8.
16. Ma J, Liu L, Che G, Yu N, Dai F, You Z. The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 2010;10:112.
17. Yoshikawa K, Mitsunaga S, Kinoshita T, et al. Impact of t u mor-associated macrophages on invasive ductal carcinoma of the pancreas head. Cancer Sci 2012;103: 2012–20.
18. Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L. The origin and function of tumor-associated macrophages. Immunol Today 1992;13:265–70.
19. Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM. M-1/M-2 Macrophages and the Th1/Th2 paradigm. J Immunol 2000;164:6166–73.
20. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Tre n d s Immunol 2002;23:549–55.
21. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 2005;23:344–6.
22. Holness CL, Simmons DL. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 1993;81:1607–13.
23. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003;3:23–35.
24. Bottazzi B, Polentarutti N, Acero R, et al. Regulation of the macrophage content of neoplasms by chemoattractants. Science 1983;220:210–12.
25. Negus RP, Stamp GW, Relf MG, et al. The detection and localization of monocyte chemoattractant protein-1 (mcp-1) in human ovarian cancer. J Clin Invest 1995;95:2391–6.
26. An T, Sood U, Pietruk T, Cummings G, Hashimoto K, Criss-man JD. In situ quantitation of inflammatory mononuclear cells in ductal infltrating breast carcinoma. Relation to prognostic parameters. Am J Pathol 1987;128:52–60.
27. Mantovani A, Allavena P, Sica A. Tumour-associated macrophages as a prototypic type ii polarised phagocyte population: role in tumour progression. Eur J Cancer 2 0 0 4;40:1660–7.
28. Tsutsui S, Yasuda K, Suzuki K, Tahara K, Higashi H, Era S. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with vegf expression and microvessel density. Oncol Rep 2005;14:425–31.
29. Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006;124:263–6.
30. Pollard JW. Macrophages define the invasive microenvironment in breast cancer. J Leukoc Biol 2008;84:623–30.
31. Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006;24 4:10–15.
32. Stathis A, Moore MJ. Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 2010;7:163–72.
33. Demeure MJ, Doffek KM, Komorowski RA, Wilson SD. Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based a s s a y. Cancer 1998;83:1328–34.
34. Kurahara H, Takao S, Maemura K, Shinchi H, Natsugoe S, Aikou T. Impact of lymph node micrometastasis in patients with pancreatic head cancer. World J Surg 2007;31:483–90.
35. Schoppmann SF, Birner P, Stockl J, et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 2002;161:947–56.
36. Zhang BC, Gao J, Wang J, Rao ZG, Wang BC, Gao JF. Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma. Med Oncol 2011;28:1447–52.
37. Caraceni A, Portenoy RK. Pain management in patients with pancreatic carcinoma. Cancer 1996;78(suppl):639–53.
38. McMahon SB. ngf as a mediator of inflammatory pain. Philos Trans R Soc Lond B Biol Sci 1996;351:431–40.
39. Lewin GR, Rueff A, Mendell LM. Peripheral and central mechanisms of ngf-induced hyperalgesia. Eur J Neurosci 1994;6:1903–12.
40. Woolf CJ. Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain. Philos Trans R Soc Lond B Biol Sci 1996;351:441–8.
41. Johnson CD, Schwall G, Flechtenmacher J, Trede M. Resection for adenocarcinoma of the body and tail of the pancreas. Br J Surg 1993;80:1177–9.
42. Brennan MF, Moccia RD, Klimstra D. Management of adenocarcinoma of the body and tail of the pancreas. Ann Surg 1996;223:506-11.