Divergent mechanistic routes for the formation of gem-dimethyl groups in the biosynthesis of complex polyketides

Angewandte Chemie - International Edition

Volumn 54, Issue 8, 2015, Pages 2370-2373

  Poust, Sean ^a   Phelan, Ryan M ^b   Deng, Kai ^b   Katz, Leonard ^c   Petzold, Christopher J ^b   Keasling, Jay D ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c Synthetic Biology Engineering Research Center   (United States)

Author keywords

Biosynthesis; Dimethylmalonyl ACP; Methylation; Polyketides; Transferases

Indexed keywords

ALKYLATION; BIOCHEMISTRY; CONDENSATION; FUNCTIONAL GROUPS; KETONES; MASS SPECTROMETRY; METHYLATION;

ACYL CARRIER PROTEINS; DIMETHYLMALONYL-ACP; GEM-DIMETHYL; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; POLYKETIDES; REACTION ORDERS; TRANSFERASES;

BIOSYNTHESIS;

ACYL CARRIER PROTEIN; EPOTHILONE DERIVATIVE; PHENOL DERIVATIVE; POLYKETIDE; POLYKETIDE SYNTHASE; THIAZOLE DERIVATIVE; YERSINIABACTIN;

CHEMISTRY; MASS SPECTROMETRY; METABOLISM; METHYLATION;

ACYL CARRIER PROTEIN; EPOTHILONES; MASS SPECTROMETRY; METHYLATION; PHENOLS; POLYKETIDE SYNTHASES; POLYKETIDES; THIAZOLES;

EID: 84922804451     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201410124     Document Type: Article

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