Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells

Journal of Nutritional Biochemistry

Volumn 25, Issue 12, 2014, Pages 1254-1262

  Abdi, J ^a   Garssen, J ^a   Faber, J ^b   Redegeld, F A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b Nutricia Nederland   (Netherlands)

Author keywords

Apoptosis; DHA; EPA; Mitochondria; Multiple myeloma; NF B; Oxidative stress

Indexed keywords

BORTEZOMIB; CASPASE 3; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NOTCH RECEPTOR; OMEGA 3 FATTY ACID; SONIC HEDGEHOG PROTEIN; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; BORONIC ACID DERIVATIVE; CASP3 PROTEIN, HUMAN; PYRAZINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SENSITIVITY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE; MONONUCLEAR CELL; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

ERINACEIDAE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARACHIDONIC ACID; BORONIC ACIDS; CASPASE 3; CELL LINE, TUMOR; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTES, MONONUCLEAR; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MULTIPLE MYELOMA; NF-KAPPA B; PYRAZINES;

EID: 84922783511     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2014.06.013     Document Type: Article

References (37)

1. Hideshima T., Chauhan D., Richardson P., Mitsiades C., Mitsiades N., Hayashi T., et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 2002, 277:16639-16647.
2. Markovina S., Callander N.S., O'Connor S.L., Kim J., Werndli J.E., Raschko M., et al. Bortezomib-resistant nuclear factor-kappaB activity in multiple myeloma cells. Mol Cancer Res 2008, 6:1356-1364.
3. Ri M., Iida S., Nakashima T., Miyazaki H., Mori F., Ito A., et al. Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia 2010, 24:1506-1512.
4. Biondo P.D., Brindley D.N., Sawyer M.B., Field C.J. The potential for treatment with dietary long-chain polyunsaturated n-3 fatty acids during chemotherapy. J Nutr Biochem 2008, 19:787-796.
5. Faber J., Berkhout M., Vos A.P., Sijben J.W., Calder P.C., Garssen J., et al. Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women. J Nutr 2011, 141:964-970.
6. Faber J., Berkhout M., Fiedler U., Avlar M., Witteman B.J., Vos A.P., et al. Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial. Clin Nutr 2013, 32:338-345.
7. Song K.S., Jing K., Kim J.S., Yun E.J., Shin S., Seo K.S., et al. Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. Pancreatology 2011, 11:574-584.
8. Fukui M., Kang K.S., Okada K., Zhu B.T. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. J Cell Biochem 2013, 114:192-203.
9. Yang T., Fang S., Zhang H.X., Xu L.X., Zhang Z.Q., Yuan K.T., et al. N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. J Nutr Biochem 2013, 24:744-753.
10. Fahrmann J.F., Hardman W.E. Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. Lipids Health Dis 2013, 12:36.
11. Hagemann T., Balkwill F., Lawrence T. Inflammation and cancer: a double-edged sword. Cancer Cell 2007, 12:300-301.
12. Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell 2010, 140:883-899.
13. Marnett L.J. Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment. J Org Chem 2012, 77:5224-5238.
14. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
15. Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005, 5:749-759.
16. Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
17. Brown L.M., Gridley G., Check D., Landgren O. Risk of multiple myeloma and monoclonal gammopathy of undetermined significance among white and black male United States veterans with prior autoimmune, infectious, inflammatory, and allergic disorders. Blood 2008, 111:3388-3394.
18. Alexandrakis M.G., Passam F.H., Sfiridaki A., Pappa C.A., Moschandrea J.A., Kandidakis E., et al. Serum levels of leptin in multiple myeloma patients and its relation to angiogenic and inflammatory cytokines. Int J Biol Markers 2004, 19:52-57.
19. Abdi J., Mutis T., Garssen J., Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS One 2013, 8:e60671.
20. Bohnhorst J., Rasmussen T., Moen S.H., Flottum M., Knudsen L., Borset M., et al. Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Leukemia 2006, 20:1138-1144.
21. Chiron D., Jego G., Pellat-Deuceunynck C. Toll-like receptors: expression and involvement in multiple myeloma. Leuk Res 2010, 34:1545-1550.
22. Fabre C., Mimura N., Bobb K., Kong S.Y., Gorgun G., Cirstea D., et al. Dual inhibition of canonical and noncanonical NF-kappaB pathways demonstrates significant antitumor activities in multiple myeloma. Clin Cancer Res 2012, 18:4669-4681.
23. Abdi J., Mutis T., Garssen J., Redegeld F. Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells. Blood Cancer J 2013, 3:e119.
24. Demchenko Y.N., Glebov O.K., Zingone A., Keats J.J., Bergsagel P.L., Kuehl W.M. Classical and/or alternative NF-kappaB pathway activation in multiple myeloma. Blood 2010, 115:3541-3552.
25. Takebe N., Harris P.J., Warren R.Q., Ivy S.P. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011, 8:97-106.
26. Calder P.C. Mechanisms of action of (n-3) fatty acids. J Nutr 2012, 142:592S-599S.
27. Granci V., Cai F., Lecumberri E., Clerc A., Dupertuis Y.M., Pichard C. Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway. Br J Nutr 2012, 1-8.
28. Weikang Zhang, Yueping Long, Zhang Jinghui, Wang Chunyou Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells. J Huazhong Univ Sci Technol 2007, 27:547-550.
29. Hegde S., Kaushal N., Ravindra K.C., Chiaro C., Hafer K.T., Gandhi U.H., et al. Delta12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood 2011, 118:6909-6919.
30. Jakobsen C.H., Storvold G.L., Bremseth H., Follestad T., Sand K., Mack M., et al. DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis. J Lipid Res 2008, 49:2089-2100.
31. Novak T.E., Babcock T.A., Jho D.H., Helton W.S., Espat N.J. NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Physiol Lung Cell Mol Physiol 2003, 284:L84-L89.
32. Narayanan B.A., Narayanan N.K., Simi B., Reddy B.S. Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. Cancer Res 2003, 63:972-979.
33. Blotta S., Jakubikova J., Calimeri T., Roccaro A.M., Amodio N., Azab A.K., et al. Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. Blood 2012, 120:5002-5013.
34. Nefedova Y., Sullivan D.M., Bolick S.C., Dalton W.S., Gabrilovich D.I. Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Blood 2008, 111:2220-2229.
35. Lim K., Han C., Dai Y., Shen M., Wu T. Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther 2009, 8:3046-3055.
36. Staudt L.M. Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol 2010, 2:a000109.
37. Hideshima T., Ikeda H., Chauhan D., Okawa Y., Raje N., Podar K., et al. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells. Blood 2009, 114:1046-1052.