Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation

Aging Cell

Volumn 14, Issue 1, 2015, Pages 67-77

  Parkinson, Leigh G ^a,b   Toro, Ana ^a,b   Zhao, Hongyan ^a,b   Brown, Keddie ^a   Tebbutt, Scott J ^a,c   Granville, David J ^a,b  

^a ST PAUL S HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Aging; Collagen; Extracellular matrix; Fibronectin; Granzyme B; Matrix metalloproteinase; Photoaging; Skin; Ultraviolet light

Indexed keywords

COLLAGEN; FIBRONECTIN; GRANZYME B; INTERSTITIAL COLLAGENASE; PROTEINASE; PROTEOGLYCAN; DECORIN; GRANZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DENSITY; ENZYME DEFICIENCY; EXTRACELLULAR MATRIX; KERATINOCYTE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SKIN; SKIN FIBROBLAST; SOLAR RADIATION; ULTRAVIOLET IRRADIATION; WILD TYPE; WRINKLE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL COUNT; CUTANEOUS PARAMETERS; DEFICIENCY; DERMIS; ENZYMOLOGY; FEMALE; FIBROBLAST; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; RADIATION RESPONSE; ULTRAVIOLET RADIATION;

MUS;

ANIMALS; CELL COUNT; COLLAGEN; DECORIN; DERMIS; DOSE-RESPONSE RELATIONSHIP, RADIATION; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; FIBRONECTINS; GRANZYMES; MAST CELLS; MATRIX METALLOPROTEINASE 1; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; PROTEOLYSIS; SKIN; SKIN AGING; ULTRAVIOLET RAYS;

EID: 84922756072     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12298     Document Type: Article

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