Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains

Matrix Biology

Volumn 41, Issue , 2015, Pages 44-55

  Bot, Simonetta ^a   Andreuzzi, Eva ^a   Capuano, Alessandra ^a   Schiavinato, Alvise ^b,d   Colombatti, Alfonso ^a,c   Doliana, Roberto ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Domain interaction; Elastic fiber; Extracellular matrix; Multimer assembly

Indexed keywords

ANTIBODY; COMPLEMENT COMPONENT C1Q; EMILIN1 PROTEIN; EMILIN2 PROTEIN; GLYCOPROTEIN; POLYMER; UNCLASSIFIED DRUG; ELASTIN MICROFIBRIL INTERFACE LOCATED PROTEIN; EMILIN2 PROTEIN, HUMAN; EMILIN2 PROTEIN, MOUSE; MEMBRANE PROTEIN; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FUNGAL CELL CULTURE; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SACCHAROMYCES CEREVISIAE; TISSUE SECTION; TWO HYBRID SYSTEM; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; CELL CULTURE; CHEMISTRY; CYTOLOGY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; OSTEOBLAST; PROTEIN MULTIMERIZATION; SPLEEN;

ANIMALS; BINDING SITES; CELLS, CULTURED; GLYCOPROTEINS; HEK293 CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; OSTEOBLASTS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SPLEEN; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84922731104     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2014.10.001     Document Type: Article

References (38)

1. Braghetta P., Ferrari A., de Gemmis P., Zanetti M., Volpin D., Bonaldo P., Bressan G.M. Expression of the EMILIN1 gene during mouse development. Matrix Biol. 2002, 21:603-609.
2. Braghetta P., Ferrari A., De Gemmis P., Zanetti M., Volpin D., Bonaldo P., Bressan G.M. Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family. Matrix Biol. 2004, 22:549-556.
3. Bressan G.M., Castellani I., Colombatti A., Volpin D. Isolation and characterization of a 115,000-dalton matrix-associated glycoprotein from chick aorta. J. Biol. Chem. 1983, 258:13262-13267.
4. Bressan G.M., Daga-Gordini D., Colombatti A., Castellani I., Marigo V., Volpin D. Emilin, a component of elastic fibers preferentially located at the elastin-microfibrils interface. J. Cell Biol. 1993, 121:201-212.
5. Charbonneau N.L., Dzamba B.J., Ono R.N., Keene D.R., Corson G.M., Reinhardt D.P., Sakai L.Y. Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences. J. Biol. Chem. 2003, 278:2740-2749.
6. Colombatti A., Bressan G.M., Castellani I., Volpin D. Glycoprotein 115, a glycoprotein isolated from chick blood vessels, is widely distributed in connective tissue. J. Cell Biol. 1985, 100:18-26.
7. Colombatti A., Bonaldo P., Volpin D., Bressan G.M. The elastin associated glycoprotein gp 115. Synthesis and secretion by chick cells in culture. J. Biol. Chem. 1988, 263:17534-17540.
8. Colombatti A., Doliana R., Bot S., Canton A., Mongiat M., Mungiguerra G., Paron-Cilli S., Spessotto P. The EMILIN protein family. Matrix Biol. 2000, 19:289-301.
9. Colombatti A., Spessotto P., Doliana R., Mongiat M., Bressan G.M., Esposito G. The EMILIN/Multimerin family. Front. Immunol. 2012, 2(93):1-13.
10. Danussi C., Spessotto P., Petrucco A., Wassermann B., Sabatelli P., Montesi M., Doliana R., Bressan G.M., Colombatti A. Emilin1 deficiency causes structural and functional defects of lymphatic vasculature. Mol. Cell. Biol. 2008, 12:4026-4039.
11. Danussi C., Petrucco A., Wassermann B., Pivetta E., Modica T.M., Del Bel Belluz L., Colombatti A., Spessotto P. EMILIN1α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J. Cell Biol. 2011, 195:131-145.
12. Danussi C., Petrucco A., Wassermann B., Modica T.M., Pivetta E., Del Bel Belluz L., Colombatti A., Spessotto P. An EMILIN1-negative microenvironment promotes tumor cell proliferation and lymph node invasion. Cancer Prev. Res. (Phila) 2012, 5:1131-1143.
13. Danussi C., Del Bel Belluz L., Pivetta E., Modica T.M., Muro A., Wassermann B., Doliana R., Sabatelli P., Colombatti A., Spessotto P. EMILIN1/α9β1 integrin interaction is crucial in lymphatic valve formation and maintenance. Mol Cell Biol. 2013, 33:4381-4394.
14. Doliana R., Mongiat M., Bucciotti F., Giacomello E., Deutzmann R., Volpin D., Bressan G.M., Colombatti A. EMILIN, a component of the elastic fiber and a new member of the Clq/turnor necrosis factor superfamily of proteins. J. Biol. Chem. 1999, 274:16773-16781.
15. Doliana R., Bot S., Bonaldo P., Colombatti A. EMI, a novel cysteine rich domain of EMILINs and other extracellular proteins, interacts with the gC1q domains and participates in multimerization. FEBS Lett. 2000, 484:164-168.
16. Doliana R., Bot S., Mungiguerra G., Canton A., Cilli S.P., Colombatti A. Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily. J. Biol. Chem. 2001, 276:12003-12011.
17. Ehlen H.W., Chinenkova M., Moser M., Munter H.M., Krause Y., Gross S., Brachvogel B., Wuelling M., Kornak U., Vortkamp A. Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J. Bone Miner. Res. 2013, 28:246-259.
18. Kishore U., Gaboriaud C., Waters P., Shrive A.K., Greenhough T.J., Reid K.B., Sim R.B., Arlaud G.J. C1q and tumor necrosis factor superfamily: modularity and versatility. Trends Immunol. 2004, 25:551-561.
19. Lichti U., Anders J., Yuspa S.H. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat. Protoc. 2008, 3:799-810.
20. Lin G., Tiedemann K., Vollbrandt T., Peters H., Batge B., Brinckmann J., Reinhardt D.P. Homo and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils. J. Biol. Chem. 2002, 277:50795-50804.
21. Marastoni S., Andreuzzi E., Paulitti A., Colladel R., Pellicani R., Todaro F., Schiavinato A., Bonaldo P., Colombatti A., Mongiat M. EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration. J. Pathol. 2014, 232:391-404.
22. Marson A., Rock M.J., Cain S.A., Freeman L.J., Morgan A., Mellody K., Shuttleworth C.A., Baldock C., Kielty C.M. Homotypic fibrillin-1 interactions in microfibril assembly. J. Biol. Chem. 2005, 280:5013-5021.
23. Mongiat M., Mungiguerra G., Bot S., Mucignat M.-T., Giacomello E., Doliana R., Colombatti A. Self-assembly and supramolecular organization of EMILIN. J. Biol. Chem. 2000, 275:25471-25480.
24. Mongiat M., Ligresti G., Marastoni S., Lorenzon E., Doliana R., Colombatti A. Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2. Mol. Cell. Biol. 2007, 27:7176-7187.
25. Mongiat M., Marastoni S., Ligresti G., Lorenzon E., Schiappacassi M., Perris R., Frustaci S., Colombatti A. The extracellular matrix glycoprotein elastin microfibril interface located protein 2: a dual role in the tumormicroenvironment. Neoplasia 2010, 12:294-304.
26. Muragaki Y., Jacenko O., Apte S., Mattel M.-G., Ninomiya Y., Olsen B.R. The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1. J. Biol. Chem. 1991, 266:7721-7727.
27. Pereira L., Andrikopoulos K., Tian J., Lee S.Y., Keene D.R., Ono R., Reinhardt D.P., Sakai L.Y., Biery N.J., Bunton T., Dietz H.C., Ramirez F. Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat. Genet. 1997, 17:218-222.
28. Pereira L., Lee S.Y., Gayraud B., Andrikopoulos K., Shapiro S.D., Bunton T., Biery N.J., Dietz H.C., Sakai L.Y., Ramirez F. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3819-3823.
29. Ramirez F. Fibrillin mutations in Marfan syndrome and related phenotypes. Curr. Opin. Genet. Dev. 1996, 6:309-315.
30. Reinhardt D.P., Gambee J.E., Ono R.N., Bachinger H.P., Sakai L.Y. Initial steps in assembly of microfibrils. Formation of disulfide-cross-linked multimers containing fibrillin-1. J. Biol. Chem. 2000, 275:2205-2210.
31. Ritty T.M., Roth R., Heuser J.E. Tendon cell array isolation reveals a previously unknown fibrillin-2-containing macromolecular assembly. Structure (Camb) 2003, 11:1179-1188.
32. Shapiro L., Scherer P.E. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998, 8:335-338.
33. Spessotto P., Cervi M., Mucignat M.T., Mungiguerra G., Sartoretto I., Doliana R., Colombatti A. beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain. J. Biol. Chem. 2003, 278:6160-6167.
34. Verdone G., Doliana R., Corazza A., Colebrooke S.A., Spessotto P., Bot S., Bucciotti F., Capuano A., Silvestri A., Viglino P., Campbell I.D., Colombatti A., Esposito G. The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the alpha4beta1 integrin. J. Biol. Chem. 2008, 283:18947-18956.
35. Zacchigna L., Vecchione C., Notte A., Cordenonsi M., Dupont S., Maretto S., Cifelli G., Ferrari A., Maffei A., Fabbro C., Braghetta P., Marino G., Selvetella G., Aretini A., Colonnese C., Bettarini U., Russo G., Soligo S., Adorno M., Bonaldo P., Volpin D., Piccolo S., Lembo G., Bressan G.M. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell 2006, 124:929-942.
36. Zanetti M., Braghetta P., Sabatelli P., Mura I., Doliana R., Colombatti A., Volpin D., Bonaldo P., Bressan G.M. EMILIN1 deficiency induces elastogenesis and vascular cell defects. Mol. Cell. Biol. 2004, 24:638-650.
37. Zhang Y., Chen Q. The noncollagenous domain 1 of type X collagen. A novel motif for trimer and higher order multimer formation without a triple helix. J. Biol. Chem. 1999, 274:22409-22413.
38. Zhang H., Hu W., Ramirez F. Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. J. Cell Biol. 1995, 129:1165-1176.