The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the α4β1 integrin

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 18947-18956

  Verdone, Giuliana ^a,e   Doliana, Roberto ^b   Corazza, Alessandra ^a,d   Colebrooke, Simon A ^c   Spessotto, Paola ^b   Bot, Simonetta ^b   Bucciotti, Francesco ^b   Capuano, Alessandra ^b   Silvestri, Alessandra ^b   Viglino, Paolo ^a,d   Campbell, Iain D ^c   Colombatti, Alfonso ^a,b   Esposito, Gennaro ^a,d  

^a UNIVERSITY OF UDINE   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^e Ist Biochimico Ital G L   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE; BLOOD VESSEL PROSTHESES; ENZYME ACTIVITY; FLOW INTERACTIONS; GLYCOPROTEINS; NUCLEAR MAGNETIC RESONANCE; SELF ASSEMBLY;

DO-MAINS; EXTRACELLULAR MATRIXES; FAMILY MEMBERS; GLUTAMIC ACID RESIDUES; HAPTOTACTIC MIGRATIONS; HOMOTRIMER; INTEGRIN; INTEGRINS; INTERACTION SITES; INTERFACE DOMAINS; SANDWICH FOLDS; SOLUTION STRUCTURES; T CELLS;

ENDOTHELIAL CELLS;

EMILIN1; EMILIN2; GLUTAMIC ACID; SCLEROPROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; ELASTIN MICROFIBRIL INTERFACE LOCATED PROTEIN; EMILIN2 PROTEIN, HUMAN; GLYCOPROTEIN; MEMBRANE PROTEIN;

ARTICLE; BETA SHEET; CELL ADHESION; CELL MIGRATION; CRYSTAL STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE; BLOOD PRESSURE; CELL MOTION; CHEMICAL STRUCTURE; CHEMISTRY; FEMALE; GENETICS; HOMEOSTASIS; LEUKEMIA CELL LINE; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TROPHOBLAST; UTERUS;

BLOOD PRESSURE; CELL ADHESION; CELL MOVEMENT; FEMALE; GLYCOPROTEINS; HOMEOSTASIS; HUMANS; INTEGRIN ALPHA4BETA1; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TROPHOBLASTS; UTERUS;

EID: 49649084252     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801085200     Document Type: Article

References (45)

1. Colombatti, A., Bressan, G. M., Castellani, I., and Volpin, D. (1985) J. Cell Biol. 100, 18-26
2. Bressan, G. M., Daga-Gordini, D., Colombatti, A., Castellani, I., Marigo, V., and Volpin, D. (1993) J. Cell Biol. 121, 201-212
3. Doliana, R., Mongiat, M., Bucciotti, F., Giacomello, E., Deutzmann, R., Volpin, D., Bressan, G. M., and Colombatti, A. (1999) J. Biol. Chem. 274, 16773-16781
4. Colombatti, A., Doliana, R., Bot, S., Canton, A., Mongiat, M., Mungiguerra, G., Paron-Cilli, S., and Spessotto, P. (2000) Matrix Biol. 19, 289-301
5. Zacchigna, L., Vecchione, C., Notte, A., Cordenonsi, M., Dupont, S., Maretto, S., Cifelli, G., Ferrari, A., Maffei, A., Fabbro, C., Braghetta, P., Marino, G., Selvetella, G., Aretini, A., Colonnese, C., Bettarini, U., Russo, G., Soligo, S., Adorno, M., Bonaldo, P., Volpin, D., Piccolo, S., Lembo, G., and Bressan, G. M. (2006) Cell 124, 929-942
6. Doliana, R., Bot, S., Mungiguerra, G., Canton, A., Paron Cilli, S., and Colombatti, A. (2001) J. Biol. Chem. 276, 12003-12011
7. Mongiat, M., Mungiguerra, G., Bot, S., Mucignat, M. T., Giacomello, E., Doliana, R., and Colombatti, A. (2000) J. Biol. Chem. 275, 25471-25480
8. Spessotto, P., Cervi, M., Mucignat, M. T., Mungiguerra, G., Sartoretto, I., Doliana, R., and Colombattti, A. (2003) J. Biol. Chem. 278, 6170-6177
9. Spessotto, P., Bulla, R., Danussi, C., Radillo, O., Cervi, M., Monami, G., Bossi, F., Tedesco, F., Doliana, R., and Colombatti, A. (2006) J. Cell Science 119, 4574-4584
10. Shapiro, L., and Scherer, P. E. (1998) Curr. Biol. 12, 335-338
11. Bogin, O., Kvansakul, M., Rom, E., Singer, J., Yayon, A., and Hohenester, E. (2002) Structure 10, 165-173
12. Kvansakul, M., Bogin, O., Hohenester, E., and Yayon, A. (2003) Matrix Biol. 22, 145-152
13. Gaboriaud, C., Juanhuix, J., Gruez, A., Lacroix, M., Darnault, C., Pignol, D., Verger, D., Fontecilla-Camps, J. C., and Arlaud, G. J. (2003) J. Biol. Chem. 278, 46974-46982
14. Verdone, G., Colebrooke, S. A., Boyd, J., Viglino, P., Corazza, A., Doliana, R., Mungiguerra, G., Colombatti, A., Esposito, G., and Campbell, I. D. (2004) J. Biomol. NMR 29, 91-92
15. Alon, R., Kassner, P. D., Carr, M. W., Finger, E. B., Hemler, M. E., and Springer, T. A. (1995) J. Cell Biol. 128, 1243-1253
16. Masumoto, A., and Hemler, M. E. (1993) J. Biol. Chem. 268, 228-234
17. Hauzenberger, D., Klominek, J., Bergström, S. E., and Sundqvist, K. G. (1995) Crit. Rev. Immunol. 15, 285-316
18. Salzmann, M., Pervushin, K., Wider, G., Senn, H., and Wuthrich, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13585-13590
19. Salzmann, M., Wider, G., Pervushin, K., Senn, H., and Wuthrich, K. (1999) J. Am. Chem. Soc. 121, 844-848
20. Marion, D., Kay, L. E., Sparks, S. W., Torchia, D. A., and Bax, A. (1989) J. Am. Chem. Soc. 111, 1515-1517
21. Grzesiek, A., and Bax, A. (1993) J. Am. Chem. Soc. 115, 593-595
22. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
23. Chou, J. J., Li, S., and Bax, A. (2000) J. Biomol. NMR 18, 217-227
24. Schwieters, C. D., Kuszewski, J. J., Tjandra, N., and Clore, G. M. (2003) J. Magn. Reson. 160, 66-74
25. Tjandra, N., Omichinski, J. G., Gronenborn, A. M., Clore, G. M., and Bax, A. (1997) Nat. Struct. Biol. 4, 732-738
26. Tjandra, N., and Bax, A. (1997) Science 278, 1111-1114
27. Ottiger, M., Delaglio, F., and Bax, A. (1998) J. Magn. Reson. 131, 373-378
28. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. S., and Struhl, K. (1998) in Current Protocols in Molecular Biology, pp. 10.20.1, John Wiley & Sons, Inc., New York
29. Giacomello, E., Neumayer, J., Colombatti, A., and Perris, R. (1999) BioTechniques 26, 758-766
30. Spessotto, P., Giacomello, E., and Perris, R. (2000) Methods Mol. Biol. 139, 321-343
31. Edgell, C. J., McDonald, C. C., and Graham, J. B. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 3734-3737
32. Spessotto, P., Gronkowska, A., Deutzmann, R., Perris, R., and Colombatti, A. (2003) Matrix Biol. 22, 351-361
33. Machin, M., Santomaso, A., Mazzucato, M., Cozzi, M. R., Battiston, M., De Marco, L., and Canu, P. (2006) Ann. Biomed. Eng. 34, 833-846
34. Pervushin, K., Riek, R., Wider, G., and Wüthrich, K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12366-12371
35. Wishart, D. S., and Sykes, B. D. (1994) J. Biomol. NMR 4, 171-180
36. Cornilescu, G., Delaglio, F., and Bax, A. (1999) J. Biomol. NMR 13, 289-302
37. Clements, J. M., Newham, P., Shepherd, M., Gilbert, R., Dudgeon, T. J., Needham, L. A., Edwards, R. M., Berry, L., Brass, A., and Humphries, M. J. (1994) J. Cell Sci. 107, 2127-2135
38. Kilger, G., Clements, J., and Holzmann, B. (1997) Int. Immunol. 9, 219-226
39. Vonderheide, R. H., Tedder, T. F., Springer, T. A., and Staunton, D. E. (1994) J. Cell Biol. 125, 215-222
40. Radivojac, P., Iakoucheva, L. M., Oldfield, C. J., Obradivic, C. Z., Uversky, V. N., and Dunker, A. K. (2007) Biophys. J. 92, 439-456
41. Leahy, D. J., Aukhil, I., and Erickson, H. P. (1996) Cell 84, 155-164
42. Casasnovas, J. M., Stehle, T., Liu, J. H., Wang, J. H., and Springer, T. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 4134-4139
43. Yamada, K. M. (1991) J. Biol. Chem. 266, 12809-12812
44. Michishita, M., Videm, V., and Arnaout, M. A. (1993) Cell 72, 857-867
45. Koradi, R., Billeter, M., and Wühtrich, K. (1996) J. Mol. Graph. 14, 51-55