Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis

Mucosal Immunology

Volumn 8, Issue 2, 2015, Pages 307-315

  Visekruna, A ^a,b   Linnerz, T ^a   Martinic, V ^a   Vachharajani, N ^a   Hartmann, S ^a   Harb, H ^a   Joeris, T ^b,c   Pfefferle, P I ^b   Hofer, M J ^a,d   Steinhoff, U ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c LUND UNIVERSITY   (Sweden)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; PROTEIN P52; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CD40 ANTIGEN; CYTOKINE; GAMMA INTERFERON; PROTEIN BINDING; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; LAMINA PROPRIA; MOUSE; NONHUMAN; PATHOGENESIS; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; DISEASE MODEL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE; METABOLISM; PATHOLOGY;

ANIMALS; ANTIGENS, CD40; COLITIS; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; LYMPHOCYTES; MICE; MICE, KNOCKOUT; NF-KAPPA B; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-REL; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84922700554     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.68     Document Type: Article

References (31)

1. Xavier, R.J. & Podolsky, D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007).
2. Neurath, M.F., Pettersson, S., Meyer zum Buschenfelde, K.H. & Strober, W. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat. Med. 2, 998-1004 (1996).
3. Neurath, M.F., Becker, C. & Barbulescu, K. Role of NF-kappaB in immune and inflammatory responses in the gut. Gut 43, 856-860 (1998).
4. Bonizzi, G. & Karin, M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25, 280-288 (2004).
5. Ghosh, S. & Karin, M. Missing pieces in the NF-kappaB puzzle. Cell 109, S81-S96 (2002).
6. Vallabhapurapu, S. & Karin, M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 27, 693-733 (2009).
7. Sun, S.C.&Ley, S.C.New insights into NF-kappaB regulation and function. Trends Immunol. 29, 469-478 (2008).
8. Pasparakis, M. Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat. Rev. Immunol. 9, 778-788 (2009).
9. Beinke, S. & Ley, S.C. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem. J. 382 (Pt 2), 393-409 (2004).
10. Visekruna, A., Volkov, A. & Steinhoff, U. A key role for NF-kappaB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions. Clin. Dev. Immunol. 2012, 239368 (2012).
11. Wang, J., et al. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J. Immunol. 178, 6777-6788 (2007).
12. Mason, N., Aliberti, J., Caamano, J.C., Liou, H.C. & Hunter, C.A. Cutting edge: identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli. J. Immunol. 168, 2590-2594 (2002).
13. Buonocore, S., et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
14. Diefenbach, A. & Vonarbourg, C. Innate lymphocytes induce inflammatory bowel disease. Immunol. Cell Biol. 88, 694-696 (2010).
15. Spits, H. & Di Santo, J.P. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat. Immunol. 12, 21-27 (2011).
16. Walker, J.A., Barlow, J.L. &McKenzie, A.N. Innate lymphoid cells - how did we miss them?. Nat. Rev. Immunol. 13, 75-87 (2013).
17. Spits, H., et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013).
18. Vonarbourg, C., et al. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptorexpressing RORgammat(+) innate lymphocytes. Immunity 33, 736-751 (2010).
19. Uhlig, H.H., et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25, 309-318 (2006).
20. Coope, H.J., et al. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J. 21, 5375-5385 (2002).
21. Zarnegar, B., He, J.Q., Oganesyan, G., Hoffmann, A., Baltimore, D. & Cheng, G. Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc. Natl Acad. Sci. USA 101, 8108-8113 (2004).
22. Mise-Omata, S., Kuroda, E., Niikura, J., Yamashita, U., Obata, Y. & Doi, T.S. A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J. Immunol. 179, 6596-6603 (2007).
23. Carmody, R.J., Ruan, Q., Liou, H.C. & Chen, Y.H. Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. J. Immunol. 178, 186-191 (2007).
24. Chognard, G., et al. the dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. PloS One 9, e89092 (2014).
25. Klose, C.S., et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 157, 340-356 (2014).
26. Wang, Y., et al. c-Rel is essential for the development of innate and T cellinduced colitis. J. Immunol. 180, 8118-8125 (2008).
27. Fuchs, A., et al. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-gamma-producing cells. Immunity 38, 769-781 (2013).
28. Maloy, K.J. & Uhlig, H.H. ILC1 populations join the border patrol. Immunity 38, 630-632 (2013).
29. Ito, R., et al. Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem. Biophys. Res. Commun. 377, 12-16 (2008).
30. OConnor, W. Jr, et al. A protective function for interleukin 17A in T cellmediated intestinal inflammation. Nat. Immunol. 10, 603-609 (2009).
31. Hotz, B., Visekruna, A., Buhr, H.J. & Hotz, H.G. Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing. J. Gastrointest. Surg. 14, 388-397 (2010).