Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle

Cell Calcium

Volumn 57, Issue 1, 2015, Pages 14-24

  Ainbinder, Alina ^a   Boncompagni, Simona ^b   Protasi, Feliciano ^b   Dirksen, Robert T ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Calcium signaling; Mitochondrial calcium uptake; Mitochondrial membrane potential; Mitofusin; Skeletal muscle; Tether

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MITOFUSIN 2; SMALL INTERFERING RNA; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; CALCIUM; GUANOSINE TRIPHOSPHATASE; MFN2 PROTEIN, MOUSE;

ADULT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTROPORATION; FLEXOR DIGITORUM BREVIS MUSCLE; FLEXOR MUSCLE; FOOT PAD; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MUSCLE MITOCHONDRION; MUSCLE TETANIC CONTRACTION; NONHUMAN; SARCOMERE; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; RNA INTERFERENCE; SKELETAL MUSCLE CELL;

ANIMALS; CALCIUM; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; EGTAZIC ACID; GTP PHOSPHOHYDROLASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MUSCLE FIBERS, SKELETAL; RNA INTERFERENCE; RNA, SMALL INTERFERING; SARCOPLASMIC RETICULUM;

EID: 84922679518     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2014.11.002     Document Type: Article

References (44)

1. Westerblad H., Bruton J.D., Katz A. Skeletal muscle: energy metabolism, fiber types, fatigue and adaptability. Exp. Cell Res. 2010, 316(18):3093-3099.
2. Zurlo F., et al. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J. Clin. Invest. 1990, 86(5):1423-1427.
3. Heymsfield S.B., et al. Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass. Am. J. Physiol. Endocrinol. Metab. 2002, 282(1):E132-E138.
4. Hoppins S., Lackner L., Nunnari J. The machines that divide and fuse mitochondria. Annu. Rev. Biochem. 2007, 76:751-780.
5. Santel A., Fuller M.T. Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 2001, 114(Pt 5):867-874.
6. de Brito O.M., Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456(7222):605-610.
7. Merkwirth C., Langer T. Mitofusin 2 builds a bridge between ER and mitochondria. Cell 2008, 135(7):1165-1167.
8. Yi J., et al. Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. J. Biol. Chem. 2011, 286(37):32436-32443.
9. 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 1993, 262(5134):744-747.
10. 2+ carrier in rat liver mitochondria. Biochemistry 1979, 18(26):5972-5978.
11. Patergnani S., et al. Calcium signaling around Mitochondria Associated Membranes (MAMs). Cell Commun. Signal. 2011, 9:19.
12. Boncompagni S., et al. Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures. Mol. Biol. Cell 2009, 20(3):1058-1067.
13. Ogata T., Yamasaki Y. Scanning electron-microscopic studies on the three-dimensional structure of mitochondria in the mammalian red, white and intermediate muscle fibers. Cell Tissue Res. 1985, 241(2):251-256.
14. Dirksen R.T. Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle. Appl. Physiol. Nutr. Metab. 2009, 34(3):389-395.
15. 2+] in single fibres from mouse limb muscles during repeated tetanic contractions. J. Physiol. 2003, 551(Pt 1):179-190.
16. (2+) spark suppression in skeletal muscle. Am. J. Physiol. Cell Physiol. 2011, 301(5):C1128-C1139.
17. (2+) uptake into mitochondria of mouse skeletal muscle during contraction. J. Cell Biol. 2004, 166(4):527-536.
18. 2+ from sarcoplasmic reticulum to mitochondria in skeletal muscle. J. Biol. Chem. 2006, 281(3):1547-1554.
19. Franzini-Armstrong C. ER-mitochondria communication. How privileged?. Physiology (Bethesda) 2007, 22:261-268.
20. Chen H., et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 2003, 160(2):189-200.
21. Chen H., et al. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 2010, 141(2):280-289.
22. DiFranco M., et al. DNA transfection of mammalian skeletal muscles using in vivo electroporation. J. Vis. Exp. 2009, 32.
23. Beam K.G., Knudson C.M. Calcium currents in embryonic and neonatal mammalian skeletal muscle. J. Gen. Physiol. 1988, 91(6):781-798.
24. Lueck J.D., et al. Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy. J. Gen. Physiol. 2007, 129(1):79-94.
25. Mobley B.A., Eisenberg B.R. Sizes of components in frog skeletal muscle measured by methods of stereology. J. Gen. Physiol. 1975, 66(1):31-45.
26. Loud A.V., Barany W.C., Pack B.A. Quantitative evaluation of cytoplasmic structures in electron micrographs. Lab. Invest. 1965, 14:996-1008.
27. 2+ release, and catecholaminergic polymorphic ventricular tachycardia. J. Clin. Invest. 2006, 116(9):2510-2520.
28. Talmadge R.J., Roy R.R. Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms. J. Appl. Physiol. 1993, 75(5):2337-2340.
29. Brennan J.P., et al. Mitochondrial uncoupling: with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Cardiovasc. Res. 2006, 72(2):313-321.
30. Brennan J.P., et al. FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation. Cardiovasc. Res. 2006, 72(2):322-330.
31. 2+ ion permeation and release from the sarcoplasmic reticulum. J. Gen. Physiol. 2011, 137(1):43-57.
32. Calderón J., et al. Different fibre populations distinguished by their calcium transient characteristics in enzymatically dissociated murine flexor digitorum brevis and soleus muscles. J. Muscle Res. Cell Motil. 2009, 30(3):125-137.
33. 2+ in single intact muscle fibres from transgenic mice. J. Physiol. 2003, 552(3):833-844.
34. 2+-dependent interaction of BAPTA with phospholipids. FEBS Lett. 2004, 576(1-2):41-45.
35. Putney J.W. Calcium signaling. Methods in signal transduction 2006, CRC/Taylor & Francis, Boca Raton, 509 p. 2nd ed.
36. 2+] at the month of a calcium channel. J. Neurosci. 1997, 17(18):6961-6973.
37. Garcia-Perez C., et al. Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points. Am. J. Physiol. Heart Circ. Physiol. 2011, 301(5):H1907-H1915.
38. 2+ movements within the sarcomere of fast-twitch mouse fibers stimulated by action potentials. J. Gen. Physiol. 2007, 130(3):283-302.
39. Kornmann B., et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 2009, 325(5939):477-481.
40. Luo G., et al. Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model. PLOS ONE 2013, 8(12):e82112.
41. 2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes. J. Bioenerg. Biomembr. 2000, 32(1):97-104.
42. Szalai G., et al. Calcium signal transmission between ryanodine receptors and mitochondria. J. Biol. Chem. 2000, 275(20):15305-15313.
43. Csordas G., et al. Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol. Cell 2010, 39(1):121-132.
44. Fieni F., et al. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat. Commun. 2012, 3:1317.