Glycoprotein gL-independent infectivity of pseudorabies virus is mediated by a gD-gH fusion protein

Journal of Virology

Volumn 73, Issue 4, 1999, Pages 3014-3022

  Klupp, Barbara G ^a   Mettenleiter, Thomas C ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA SEQUENCE; FUSION GENE; GENE MUTATION; HERPES VIRUS; IMMUNOBLOTTING; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; PSEUDORABIES HERPETOVIRUS; RADIOIMMUNOPRECIPITATION; TARGET CELL; VIRION; VIRUS CELL INTERACTION; VIRUS CULTURE; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS ISOLATION;

EID: 0033015078     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.4.3014-3022.1999     Document Type: Article

References (37)

1. Chiang, H.-Y., G. Cohen, and R. Eisenberg. 1994. Identification of functional regions of herpes simplex virus glycoprotein gD by using linker-insertion mutagenesis. J. Virol. 68:2529-2543.
2. Duus, K. M., and C. Grose. 1996. Multiple regulatory effects of varicellazoster virus (VZV) gL on trafficking patterns and fusogenic properties of VZV gH. J. Virol. 70:8961-8971.
3. Fehler, F., J. Herrmann, A. Saalmüller, T. C. Mettenleiter, and G. M. Keil. 1992. Glycoprotein IV of bovine herpesvirus 1-expressing cell line complements and rescues a conditionally lethal viral mutant. J. Virol. 66:6372-6390.
4. Geraghty, R. J., C. Krummenacher, G. Cohen, R. Eisenberg, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280:1618-1620.
5. Graham, F., and A. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus. Virology 52:456-467.
6. Hutchinson, L., H. Browne, V. Wargent, N. Davis-Poynter, S. Primorac, K. Goldsmith, A. C. Minson, and D. C. Johnson. 1992. A novel herpes simplex virus glyeoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH. J. Virol. 66:2240-2250.
7. Kaplan, A., and A. Vatter. 1959. A comparison of herpes simplex and pseudorabies viruses. Virology 7:394-407.
8. Karger, A., and T. C. Mettenleiter. 1993. Glycoproteins gill and gp50 play dominant roles in the biphasic attachment of pseudorabies virus. Virology 194:654-664.
9. Klupp, B. G., and T. C. Mettenleiter. Unpublished observations.
10. Klupp, B. G., and T. C. Mettenleiter. 1991. Sequence and expression of the glycoprotein gH gene of pseudorabies virus. Virology 182:732-741.
11. Klupp, B. G., N. Visser, and T. C. Mettenleiter. 1992. Identification and characterization of pseudorabies virus glycoprotein H. J. Virol. 66:3048-3055.
12. Klupp, B. G., J. Baumeister, A. Karger, N. Visser, and T. C. Mettenleiter. 1994. Identification and characterization of a novel structural glycoprotein in pseudorahies virus, gL. J. Virol. 68:3868-3878.
13. Klupp, B. G., W. Fuchs, E. Weiland, and T. C. Mettenleiter. 1997. Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virus localization of glycoprotein H. J. Virol. 71:7687-7695.
14. Kopp, A., and T. C. Mettenleiter. 1992. Stable rescue of a glycoprotein gII deletion mutant of pseudorabies virus by glycoprotein gI of bovine herpesvirus 1. J Virol. 66:2754-2762.
15. Ligas, M., and D. Johnson. 1988. A herpes simplex virus mutant in which glycoprotein D sequences are replaced by β-galactosidase sequences binds to but is unable to penetrate into cells. J. Virol. 62:1486-1494.
16. Lakács, N., H.-J. Thiel, T. C. Mettenleiter, and H.-J. Rziha. 1985. Demonstration of three major species of pseudorabies virus glycoproteins and identification of a disulfide-linked glycoprotein complex. J. Virol. 53:166-173.
17. Mettenleiter, T. C. 1989. Glycoprotein gIII deletion mutants of pseudorabies virus are impaired in virus entry. Virology 171:623-625.
18. Mettenleiter, T. C. 1994. Initiation and spread of α-herpesvirus infections. Trends Microbiol. 2:2-4.
19. Mettenleiter, T. C., and I. Rauh. 1990. A glycoprotein gX-β-galactosidase fusion gene as insertional marker for rapid identification of pseudorabies virus mutants. J. Virol. Methods 30:55-66.
20. Montgomery, R., M. S. Warner, B. J. Lum, and P. G. Spear. 1996. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/ NGF receptor family. Cell 87:427-436.
21. Nicola, A., M. Ponce de Leon, R. Xu, W. Hou, J. C. Whitbeck, C. Krummenacher, R. Montgomery, P. G. Spear, R. Eisenberg, and G. Cohen. 1998. Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM. J. Virol. 72:3595-3601.
22. Nicola, A., S. Willis, N. Naidoo, R. Eisenberg, and G. Cohen. 1996. Structure-function analysis of soluble forms of herpes simplex virus glycoprotein D. J. Virol. 70:3815-3822.
23. Peeters, B, N. de Wind, M. Hooisma, F. Wagenaar, A. Gielkens, and R. Moormann. 1992. Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion. J. Virol. 66:894-905.
24. Rauh, I., and T. C. Mettenleiter. 1991. Pseudorabies virus glycoproteins gII and gp50 are essential for virus penetration. J. Virol. 65:5348-5356.
25. Roop, C., L. Hutchinson, and D. C. Johnson. 1993. A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H. J. Virol. 67:2285-2297.
26. Rux, A. H., S. Willis, A. Nicola, W. Hou, C. Peng, H. Lou, G. H. Cohen, and R. J. Eisenberg. 1998. Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator. J. Virol. 72:7091-7098.
27. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
28. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
29. Schmidt, J., B. G. Klupp, A. Karger, and T. C. Mettenleiter. 1997. Adaptability in herpesviruses: glycoprotein D-independent infectivity of pseudorabies virus. J. Virol. 71:17-24.
30. Schreurs, C., T. C. Mettenleiter, F. Zuckermann, N. Sugg, and T. Ben-Porat. 1988. Glycoprotein gIII of pseudorabies virus is multifunctional. J. Virol. 62:2251-2257.
31. Schröder, C., G. Linde, F. Fehler, and G. M. Keil. 1997. From essential to beneficial: glycoprotein D loses importance for replication of bovine herpesvirus 1 in cell culture. J. Virol. 71:25-33.
32. Spaete, R., K. Perot, P. I. Scott, J. A. Nelson, M. F. Stinski, and C. Pachl. 1993. Coexpression of human cytomegalovirus gH with the UL115 gene product or the truncated human fibroblast growth factor receptor results in transport of gH to the cell surface. Virology 193:853-861.
33. Spear, P. G. 1993. Entry of alphaherpesviruses into cells. Semin. Virol. 4:167-180.
34. Turner, A., B. Bruun, T. Minson, and H. Browne. 1998. Glycoproteins gB. gD. and gHL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a COS cell transfection system. J. Virol. 72: 873-875.
35. Warner, M. S., R. J. Geraghty, W. Martinez, R Montgomery, J. C. Whilbeck, R. Xu, R. Eisenberg, G. Cohen, and P. G. Spear. 1998. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2. and pseudorabies virus. Virology 246:179-189.
36. Westra, D. F., K. Glazenburg, M. Harmsen, A. Tiran, A. Scheffer, G. Welling, T. The, and S. Welling-Wester. 1997. Glycoprotein H of herpes simplex virus type 1 requires glycoprotein L for transport to the surfaces of insect cells. J. Virol. 71:2285-2291.
37. Yaswen, L., E. Stephens, L. Davenport, and L. M. Hutt-Flettcher. 1993. Epstein-Barr virus glycoprotein gp85 associates with the BKRF2 gene product and is incompletely processed as a recombinant protein. Virology 195:387-396.