MAIT cells are depleted early but retain functional cytokine expression in HIV infection

Immunology and Cell Biology

Volumn 93, Issue 2, 2015, Pages 177-188

  Fernandez, Caroline S ^a   Amarasena, Thakshila ^a   Kelleher, Anthony D ^b,c   Rossjohn, Jamie ^d,e   Mccluskey, James ^a   Godfrey, Dale I ^a   Kent, Stephen J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c St Vincent's Centre for Applied Medical Research   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYTOKINE; LYMPHOCYTE SURFACE MARKER; MHC RELATED PROTEIN 1; TETRAMER; UNCLASSIFIED DRUG; VALPHA 7.2 PROTEIN; CCR6 PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY B; PROTEIN BINDING;

ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; LYMPHOCYTE FUNCTION; MUCOSA CELL; MUCOSAL ASSOCIATED INVARIANT T CELL; PHENOTYPE; PROTEIN EXPRESSION; T CELL DEPLETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; CD8+ T LYMPHOCYTE; CHRONIC DISEASE; COHORT ANALYSIS; DISEASE COURSE; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; METABOLISM; MUCOSA; PATHOLOGY;

BACTERIA (MICROORGANISMS);

CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; COHORT STUDIES; CYTOKINES; DISEASE PROGRESSION; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV INFECTIONS; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MUCOUS MEMBRANE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; PROTEIN BINDING; RECEPTORS, CCR6; T-LYMPHOCYTES;

EID: 84922649275     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2014.91     Document Type: Article

References (37)

1. Brenchley JM. Mucosal immunity in human and simian immunodeficiency lentivirus infections. Mucosal Immunol 2013; 6: 657-665
2. Klatt NR, Funderburg NT, Brenchley JM. Microbial translocation, immune activation, and HIV disease. Trends Microbiol 2013; 21: 6-13
3. Fevrier M, Dorgham K, Rebollo A. CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis. Viruses 2011; 3: 586-612
4. Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004; 200: 749-759
5. Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004; 200: 761-770
6. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12: 1365-1371
7. Jiang W, Lederman MM, Hunt P, Sieg SF, Haley K, Rodriguez B et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009; 199: 1177-1185
8. Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011; 203: 780-790
9. El-Sadr WM, Lundgren J, Neaton JD, Gordin F, Abrams D, Arduino RC et al. CD4+count-guided interruption of antiretro'l treatment. N Engl J Med 2006; 355: 2283-2296
10. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203
11. Le Bourhis L, Martin E, Peguillet I, Guihot A, Froux N, Core M et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol 2010; 11: 701-708
12. Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol 2010; 8: e1000407
13. Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 2012; 491: 717-723
14. Birkinshaw RW, Kjer-Nielsen L, Eckle SB, McCluskey J, Rossjohn J. MAITs, MR1 and vitamin B metabolites. Curr Opin Immunol 2014; 26: 7-13
15. Gold MC, Lewinsohn DM. Co-dependents: MR1-restricted MAIT cells and their antimicrobial function. Nat Rev Microbiol 2013; 11: 14-19
16. Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J et al. T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature 2014; 509: 361-365
17. Arstila T, Arstila TP, Calbo S, Selz F, Malassis-Seris M, Vassalli P et al. Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph. J Exp Med 2000; 191: 823-834
18. Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003; 422: 164-169
19. Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 2011; 117: 1250-1259
20. Martin E, Treiner E, Duban L, Guerri L, Laude H, Toly C et al. Stepwise development of MAIT cells in mouse and human. PLoS Biol 2009; 7: e54
21. Cosgrove C, Ussher JE, Rauch A, Gartner K, Kurioka A, Huhn MH et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood 2013; 121: 951-961
22. Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M et al. Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. PLoS ONE 2013; 8: e83474
23. Hansen TH, Huang S, Arnold PL, Fremont DH. Patterns of nonclassical MHC antigen presentation. Nat Immunol 2007; 8: 563-568
24. Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T et al. Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun 2013; 4: 2142
25. Reantragoon R, Kjer-Nielsen L, Patel O, Chen Z, Illing PT, Bhati M et al. Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. J Exp Med 2012; 209: 761-774
26. Porcelli S, Yockey CE, Brenner MB, Balk SP. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J Exp Med 1993; 178: 1-16
27. Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H et al. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med 1999; 189: 1907-1921
28. Reantragoon R, Corbett AJ, Sakala IG, Gherardin NA, Furness JB, Chen Z et al. Antigenloaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J Exp Med 2013; 210: 2305-2320
29. Walker LJ, Marrinan E, Muenchhoff M, Ferguson J, Kloverpris H, Cheroutre H et al. CD8alphaalpha expression marks terminally differentiated Hhman CD8+ T cells expanded in chronic viral infection. Front Immunol 2013; 4: 223
30. Leeansyah E, Ganesh A, Quigley MF, Sonnerborg A, Andersson J, Hunt PW et al. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood 2013; 121: 1124-1135
31. Eggena MP, Barugahare B, Okello M, Mutyala S, Jones N, Ma Y et al. T cell activation in HIV-seropositive Ugandans: differential associations with viral load, CD4+ T cell depletion, and coinfection. J Infect Dis 2005; 191: 694-701
32. Kjer-Nielsen L, Borg NA, Pellicci DG, Beddoe T, Kostenko L, Clements CS et al. A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J Exp Med 2006; 203: 661-673
33. Crowe NY, Uldrich AP, Kyparissoudis K, Hammond KJ, Hayakawa Y, Sidobre S et al. Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol 2003; 171: 4020-4027
34. Fernandez CS, Cameron G, Godfrey DI, Kent SJ. Ex vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques. J Immunol Methods 2012; 382: 150-159
35. Wilson MT, Johansson C, Olivares-Villagomez D, Singh AK, Stanic AK, Wang CR et al. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci USA 2003; 100: 10913-10918
36. Le Bourhis L, Mburu YK, Lantz O. MAIT cells, surveyors of a new class of antigen: development and functions. Curr Opin Immunol 2013; 25: 174-180
37. Greathead L, Metcalf R, Gazzard B, Gotch F, Steel A, Kelleher P. CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on long-term antiretroviral therapy and correlate with CD8+ T-cell immune activation. AIDS (London, England) 2014; 28: 1690-1692