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Angewandte Chemie - International Edition

Volumn 54, Issue 2, 2015, Pages 490-494

Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors

(7) Maric, Hans Michael a Kasaragod, Vikram Babu b Haugaard Kedström, Linda a Hausrat, Torben Johann c Kneussel, Matthias c Schindelin, Hermann b Strømgaard, Kristian a

a UNIVERSITY OF COPENHAGEN (Denmark)

b UNIVERSITY OF WÜRZBURG (Germany)

c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF (Germany)

Author keywords

Calorimetry; Drug design; Medicinal chemistry; Structural biology; Structure activity relationship

Indexed keywords

BINDING ENERGY; CALORIMETRY; DIMERS; NEUROPHYSIOLOGY; PEPTIDES; SCAFFOLDS (BIOLOGY);

DRUG DESIGN; INHIBITORY NEUROTRANSMITTER RECEPTORS; MEDICINAL CHEMISTRY; SCAFFOLDING PROTEINS; STRUCTURAL BIOLOGY; STRUCTURE ACTIVITY RELATIONSHIPS; THERAPEUTIC POTENTIALS; X RAY CRYSTAL STRUCTURES;

CRYSTAL ATOMIC STRUCTURE;

CARRIER PROTEIN; GEPHYRIN; MEMBRANE PROTEIN; NEUROTRANSMITTER RECEPTOR;

AMINO ACID SEQUENCE; CHEMISTRY; DIMERIZATION; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; CARRIER PROTEINS; DIMERIZATION; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; RECEPTORS, NEUROTRANSMITTER;

EID: 84922606169 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201409043 Document Type: Article

Times cited : (20)

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