Role of antioxidant enzymes in oxidative stress and immune response evaluation of aspartame in blood cells of wistar albino rats

International Food Research Journal

Volumn 21, Issue 6, 2014, Pages 2263-2272

  Arbind, K C ^a   Sheela Devi, R ^a   Sundareswaran, L ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidant; Aspartame; ATPase's enzymes; Neutrophil; Oxidative stress

Indexed keywords

ANIMALIA; RATTUS;

EID: 84922605541     PISSN: 19854668     EISSN: 22317546     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Ader, R. and Cohen, N. 1993. Psychoneuroimmunology conditioning and stress. Annual Review of Psychology 44: 53-85.
2. Andrew, J., Clifford. and Rosemaryl, W. 1988. Folate defiency in rats fed diets containing free aminoacid or intact proteins. Journal of Nutrition 118:1089-1096.
3. Babior, M. B. 1999. NADPH oxidase an update. Blood 93: 1464-1476.
4. Beulter, E. 1983. Active transport of glutathione disulfide from erythrocytes. In Larson, A., Orrenius, S., Holmgren, A., Manerwik, B. (Eds). Functions of glutathione biochemical physiological toxicological and clinical aspects, p. 65-71. New York: Raven Press.
5. Bonting, S.L. 1970. Sodium potassium activated adenosine triphosphates and cation transport. In Bitler, E.E. (Eds.). Membrane and ion transport, vol. 1. p. 257-263. London: Interscience Wiley.
6. Boyum, A. 1964. Separation of white blood cells. Nature 204:793-794.
7. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72:248-254.
8. Brigelius, R. 1986. Regulation of glucose-6-phosphate dehydrogenase under oxidative stress. In Rotho, G. (Eds). Superoxide and superoxide dismutase in chemistry biology and medicine, p. 401-403. BV: Elsevier Science Publishers.
9. Burgert, S. L., Andersen, D.W., Stegink, L.D., Takeuchi, H. and Schedl, H. P. 1991. Metabolism of aspartame and its L-phenylalanine methyl ester decomposition product by porcine gut. Metabolism 40: 612.
10. Butchko, H. H. and Stargel, W.W. 2001. Aspartame scientific evaluation in the post marketing period. Regulatory Toxicology and Pharmacology 34(3): 221-233.
11. Chance, B., Greenstein, D.S. and Roughton, R.J.W. 1952. The mechanism of catalase action steady state analysis. Archives of Biochemistry and Biophysics 37: 301-339.
12. Chang, J.R. and Xu, D.Q. 2006. Effects of formaldehyde on the activity of superoxide dismutase and glutathione peroxidase and the concentration of malondialdehyde. Wei Sheng Yan Jiu 35(5): 653-655.
13. Chohan, N.D., Hughes, A.A. and Johnson, P.J. 2001. Clinical laboratory test values and implication, p. 385. Pennsylvania: Springhouse.
14. Clemens, M.R., Einsele, H. and Waller, H.D. 1983. Oxidant damage of normal and glucose 6-phosphate dehydrogenase (G6PD)-deficient red blood cells is enhanced by iron-EDTA complex. International Journal of Biochemistry 7: 281-290.
15. Crockett-Torabri, E. 1998. Selectins and mechanisms of signal transduction. Journal of Leukocyte Biology 63: 1-14.
16. Davoli, E. 1986. Serum methanol concentrations in rats and in men after a single dose of aspartame. Food and Chemical Toxicology 24: 187-189.
17. Dodge J.D., Mitchell, G. and Honatian, D.J. 1963. The preparation and chemical characteristics of hemoglobin free ghosts of human red blood cells. Archives of Biochemistry and Biophysics 180:119-130.
18. European Food Safety Authority (EFSA). 2006. Opinion of the scientific panel on food additives, flavorings processing aids and materials in contact with food (AFC) on a request from the commission related to a new long-term carcinogenicity study on aspartame. European Food Safety Authority Journal 356:1-44.
19. Fallon, J., Eddy, L., Weiner, J. and Pizzo, P.A. 1989. Human immunodeficiency virus infection in children. The Journal of Pediatrics 144: 1-30
20. Feldman, S. and Conforti, N. 1980. Participation of dorsal hippocampus in the glucocorticoids feedback effect on adrenocortical activity. Neuroendocrinology 30:52-55.
21. Fiske, C.H. and Subbarow, Y. 1925. The colorimetric determination of phosphorous. The Journal of Biological Chemistry 63:75-80.
22. George, J. 2003. Ascorbic acid concentrations in dimethyl nitrosamine-induced hepatic fibrosis in rats. Clinica Chimica Acta Journal 35: 39-47.
23. Gifford, R.H. and Malawista, S.E. 1970. A simple rapid micro method for detecting chronic granulomatous disease of childhood. Journal of Clinical Laboratory Analysis 75: 511-519.
24. Gokkuou, C., Ademolu, E. and Turkolu. 1996. Thymosin protects liver and aorta from oxidative damage in atherosclerotic rabbits. Life Science Journal 59:1059-1067.
25. Gulec, M., Gurel, A. and Armutcu, F. 2006. Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats. Molecular and Cellular Biochemistry 90: 61-67.
26. Halliwell, B. and Gutteridge, J.M.C. 1999. Free radicals in biology and medicine, 3rd edn. p. 246-350. New York: Oxford University Press.
27. Hjerten, S. and Pan, H. 1983. Purification and characterization of two forms of a low affinity Ca2+ atpase from erythrocyte membranes. Biochimica et Biophysica Acta 28: 281-288.
28. Horn, H.D. and Burns, F.H. 1978. Assay of glutathione reductase activity. In Bergemeyer, H.V. (Eds). Methods of Enzymatic Analysis, p. 142-146. New York: Academic Press.
29. Jain, K.S. and Shohet, S.B. 1981. Calcium potentiates the peroxidation of erythrocyte membrane lipids. Biochimica et Biophysica Acta 42: 46-54.
30. Karim, A. and Burns, T. 1996. Metabolism and pharmacokinetics of radio labeled aspartame in normal subjects. In Tschanz, C., Butchko, H.H., Stargel, W.W. and Kotsonis, F.N. (Eds). The clinical evaluation of a food additive assessment of aspartame, p.87-113. New York: Boca Raton.
31. Khan, S.M. 2006. Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticide induced liver injury. Cell Biochemistry and Function 24: 327-332.
32. Kobayashi, T. and Seguchi, H. 1999. Novel insight into current models of NADPH oxidase regulation, assembly and localization in human polymorph nuclear leukocytes. Histology and Histopathology 14:1295-1308.
33. Kobayashi, T., Robinson, J. M. and Seguchi, H. 1998. Identification of intracellular sites of superoxide production in stimulated neutrophils. Journal of Cell Science 111: 81-91.
34. Kosawer, N.J., Zipser, Y. and Faltin, Z. 1991. Membrane thiol disulfide status in glucose-6-phosphate dehydrogenase deficient red cells. Relationship to cellular glutathione. Biochimica et Biophysica Acta 58:152-160.
35. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. 1951. Protein measurement with folin phenol reagent. The Journal of Biological Chemistry 193: 265-275.
36. Maker, A.B. and Tephly, T.R. 1976. Methanol in poisoning folate deficient rats. Nature 261: 715-716.
37. Marklund, S. and Marklund, G. 1974. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry 47: 469-474.
38. Matsumoto, K., Yobimoto, K., Huong, N.T., Abdel-Fattah, M., Hien, T.V. and Watanabe, H. 1999. Psychological stress-induced enhancement of lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice. Brain Research 39: 74-84.
39. Mccann, S.M. 1997. The nitric oxide hypothesis of brain aging. Experimental Gerentology 32: 431-440.
40. McEver, R., Moore, K.L. and Cummings, R.D. 1995. Leukocyte trafficking mediated by selectin carbohydrate interaction. The Journal of Biological Chemistry 70: 11025-11028.
41. Ming, H., Wang, S.Y., Craig, A., Meadows. and Shirley, W. 1989. Methotrexate effects on folate status and the deoxyuridine suppression test in rats. Nutrition Research 9(4): 431-444.
42. Moncada, S. and Higgs, A. 1993. The L-arginine-nitric oxide pathway. The New England Journal of Medicine 29: 2002-2012.
43. Moron, M.S., Difieree, J.W. and Mannervik, K.B. 1979. Levels of glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochimica et Biophysica Acta 82: 67-68.
44. Mosmann, T. R. and Sad, S. 1996. The expanding universe of t-cell subsets Th1, Th2 and more. Immunology Today 17: 138-146.
45. Ohkawa, H., Ohishi, N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95: 351-358.
46. Ohnishi, T., Suzuki, T., Suzuki, Y. and Ozawa, K. 1982. A comparative study of plasma membrane Mg2+ atpase activities in normal, regenerating and malignant cells. Biochimica et Biophysica Acta 84: 67-74.
47. Omaye, S. T., Turnbull, J.D. and Sauberlich, H. E. 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods in Enzymology 62: 1-11.
48. Oyama, Y., Sakai, H., Arata, T., Okano, Y., Akaike, N., Sakai, K. and Noda, K. 2002. Cytotoxic effects of methanol, formaldehyde and formate on dissociated rat thymocytes a possibility of aspartame toxicity. Cell Biology and Toxicology 18(1): 43-50.
49. Parthasarathy, J.N., Ramasundaram, S.K., Sundaramahalingam, M. and Pathinasamy, S.D. 2006. Methanol induced oxidative stress in rat lymphoid organs. Journal of Occupational Health 48: 20-27.
50. Pasoe, G. A., Olafsdottir, K. and Reed, D.J. 1987. Vitamin E protection against chemical induced injury maintenance of cellular protein thiols as a cytoprptective mechanism. Archives of Biochemistry and Biophysics 56:150-168.
51. Pigeolet, E., Corbisler, P., Houbion, A., Lambert, D., Mitchiels, C., Raes, M., Zachary. and Remaele, J. 1990. Glutathione peroxidase superoxide dismutase and catalase inactivation by peroxides and oxygen derived free radicals. Mechanism of Ageing and Development 51: 283-297.
52. Pragasam, V., Kalaiselvi, P., Sumitra, K., Srinivasan, S. and Varalakshmi, P. 2005. Counteraction of oxalate induced nitrosative stress by supplementation of L-arginine, a potent antilithic agent. Clinica Chimica Acta Journal 54:159-166.
53. Puri, A., Saxena, R., Saxena, R.P., Saxena, K.C., Srivastava, T. and Andon, J.S. 1994. Immunostimulant activity of nyctanthes arbor-tristis. Journal of Ethno Pharmacology 42: 31-37.
54. Quist, E.E. 1980. Regulation of erythrocyte membrane shape by calcium ion. Biochemical and Biophysical Research Communication 92: 631-637.
55. Rabinowitz, J.C. and Pricer, W.E. 1956. Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid. Journal of American Chemical Society 78 (21): 5702-5704.
56. Robinson, J.M. and Badwey, J.A. 1995. The NADPH oxidase complex of phagocytic leukocytes A biochemical and cytochemical view. Histochemistry and Cell Biology 103:163-180.
57. Rotruck, J.T., Pope, A.L., Ganther, H.E., Swanson, A.B., Hafeman, D.G. and Hoekstra, W.G. 1973. Selenium biochemical role as a component of glutathione peroxidase. Science 179: 588-590
58. Seth, P. and Srinivas, R.V. 1981. Circulating immune complex in cervical cancer simple method for detection and characterization. Indian Journal of Medical Research 73: 926-929.
59. Sinha, A. K. 1972. Colorimetric assay of catalase. Analytical Biochemistry 47: 389-394.
60. Smith, C.W., Marlin, S.D., Rothelin, R., Toman, C. and Anderson, D.C. 1989. Cooperative interaction of LFA-1 and Mac-1with intercellular adhesion molecule-1in facilitating adherence and endothelial migration of human neutrophils in vitro. Journal of Clinical Investigation 83: 2008-2017.
61. Springer, T.A. 1995. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annual Review of Physiology 57: 827-872.
62. Srinivasan, S., Pragasam, V., Jenitha, X., Kalaiselvi, P., Muthu, V. and Varalakshmi P. 2004. Oxidative stress in urogenital tuberculosis patients a predisposing factor for renal stone formation-amelioration by vitamin E supplementation. Clinica Chemica Acta Journal 50:57-63.
63. Stegink, L.D., Brummel, M. C., McMartin, K. E., Martin G-Amat, Filer, L. J. Jr., Baker, G.L. and Tephly, T.R. 1981. Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame. Journal of Toxicology and Environmental Health 7: 281-290.
64. Stern, A. 1989. Drug-induced oxidative denaturation in red blood cells. Seminar in Hematology 26: 301-306.
65. Tephly, T. R. and Maker, A. B. 1976. Methanol in poisoning folate deficient rats. Nature; 261: 715-716.
66. Trocho, C., Pardo R., Rafecas, I., Virgili, J., Remesar, X., Fernandez-Lopez, J.A. and Alemany, M. 1998. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Science 63(5): 337-349.
67. Upasani, C. D. and Balaraman, R. 2001. Effect of vitamin E, Vitamin C and Spirulina on the levels of membrane bound enzymes and lipids in some organs of rats exposed to lead. Indian Journal of Pharmacology 33:185-191.
68. Vidyasagar, J., Karunakar, N., Reddy, M.S., Rajnarayana, K., Surender, T. and Krishna, D.R. 2004. Oxidative stress and antioxidant status in acute organophosphorous insecticide poisoning. Indian Journal of Pharmacology 36:76-79.
69. Wilkinson, P.C. 1978. Neutrophil adhesion test in handbook of experimental pharmacology, p. 109. Berlin: Springer-Verlag.
70. Wilkinson, P. C. 1977. Phagocytosis of killed Candida albicans techniques in clinical immunology, p. 212. Oxford: Blackwell Publication.