The biology of radiosurgery and its clinical applications for brain tumors

Neuro-Oncology

Volumn 17, Issue 1, 2015, Pages 29-44

  Kondziolka, Douglas ^a,b   Shin, Samuel M ^a,b   Brunswick, Andrew ^a,b   Kim, Irene ^a,b   Silverman, Joshua S ^a,b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain tumor; Metastases; Radiobiology; Radiosurgery; Schwannoma

Indexed keywords

ACOUSTIC NEURINOMA; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL; BRAIN METASTASIS; BRAIN TUMOR; CANCER RADIOTHERAPY; CANCER SURGERY; CRANIAL NERVE; CRANIOPHARYNGIOMA; EPENDYMOMA; GLIOBLASTOMA; HUMAN; HYPOPHYSIS ADENOMA; MENINGIOMA; NONHUMAN; OUTCOME ASSESSMENT; PATIENT SAFETY; RADIOSURGERY; STEREOTACTIC RADIOSURGERY; THERAPY EFFECT; BRAIN NEOPLASMS; GLIOMA; METASTASIS; NEUROECTODERMAL TUMORS; PATHOPHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

BRAIN NEOPLASMS; GLIOMA; HUMANS; MENINGIOMA; NEOPLASM METASTASIS; NEUROECTODERMAL TUMORS; RADIOSURGERY; TREATMENT OUTCOME;

EID: 84922583188     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou284     Document Type: Article

References (202)

1. Sheehan JP, Williams BJ, Yen CP. Stereotactic radiosurgery for WHO grade I meningiomas. J Neurooncol. 2010;99(3):407-416.
2. Withers HR. The Four Rs of Radiotherapy. In: Adler H, Lett JT, Zelle M, eds, Advances in Radiation Biology. Vol 1. New York: Academic Press; 1975;241-247.
3. Steel GG, McMillan TJ, Peacock JH. The 5Rs of radiobiology. Int J Radiat Biol. 1989;56(6):1045-1048.
4. Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925-931.
5. Golden EB, Demaria S, Schiff PB, et al. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res. 2013;1(6):365-372.
6. Deepak Khuntia JH, Suh WT, et al. Stereotactic irradiation: Linear accelerator and gamma knife. In: Tepper LLGaJE, eds. Clinical Radiation Oncology. 2nd Ed. Philadelphia, PA: Elsevier; 2007; 331-343.
7. Kondziolka D, Niranjan A, Lunsford LD, et al. Radiobiology of radiosurgery. Prog Neurol Surg. 2007;20:16-27.
8. Santacroce A, Kamp MA, Budach W, et al. Radiobiology of radiosurgery for the central nervous system. BioMed Res Intl. 2013;2013:362761.
9. Hall EJ, Brenner DJ. The radiobiology of radiosurgery: rationale for different treatment regimes for AVMs and malignancies. Int J Radiat Oncol Biol Phys. 1993;25(2):381-385.
10. Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol. 1989;62(740):679-694.
11. Kirkpatrick JP, Meyer JJ, Marks LB. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Semin Radiat Oncol. 2008;18(4):240-243.
12. Hanin LG, Zaider M. Cell-survival probability at large doses: an alternative to the linear-quadratic model. Phys Med Biol. 2010; 55(16):4687-4702.
13. Park HJ, Griffin RJ, Hui S, et al. Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res. 2012; 177(3):311-327.
14. Guerrero M, Li XA. Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy. Phys Med Biol. 2004;49(20):4825-4835.
15. Brenner DJ. The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin Radiat Oncol. 2008;18(4):234-239.
16. Ma L, Larson D, Petti P, et al. Boosting central target dose by optimizing embedded dose hot spots for gamma knife radiosurgery. Stereotact Funct Neurosurg. 2007;85(6):259-263.
17. Kondziolka D, Lacomis D, Niranjan A, et al. Histological effects of trigeminal nerve radiosurgery in a primate model: implications for trigeminal neuralgia radiosurgery. Neurosurgery. 2000;46(4): 971-976, discussion 976-977.
18. Zhao ZF, Yang LZ, Jiang CL, et al. Gamma Knife irradiationinduced histopathological changes in the trigeminal nerves of rhesus monkeys. J Neurosurg. 2010;113(1):39-44.
19. Schneider BF, Eberhard DA, Steiner LE. Histopathology of arteriovenous malformations after gamma knife radiosurgery. J Neurosurg. 1997;87(3):352-357.
20. Yamamoto M, Jimbo M, Kobayashi M, et al. Long-term results of radiosurgery for arteriovenous malformation: neurodiagnostic imaging and histological studies of angiographically confirmed nidus obliteration. Surg Neurol. 1992;37(3):219-230.
21. Szeifert GT, Kemeny AA, Timperley WR, et al. The potential role of myofibroblasts in the obliteration of arteriovenous malformations after radiosurgery. Neurosurgery. 1997;40(1): 61-65, discussion 65-66.
22. Lunsford LD, Kondziolka D, Flickinger JC, et al. Stereotactic radiosurgery for arteriovenous malformations of the brain. J Neurosurg. 1991;75(4):512-524.
23. OConnor MM, Mayberg MR. Effects of radiation on cerebral vasculature: a review. Neurosurgery. 2000;46(1):138-149, discussion 150-131.
24. Tu J, Stoodley MA, Morgan MK, et al. Responses of arteriovenous malformations to radiosurgery: ultrastructural changes. Neurosurgery. 2006;58(4):749-758, discussion 749-758.
25. Tu J, Li Y, Hu Z, et al. Radiosurgery inhibition of the Notch signaling pathway in a rat model of arteriovenous malformations. J Neurosurg. 2014;120(6):1385-1396.
26. Ding D, Yen CP, Starke RM, et al. Outcomes following singlesession radiosurgery for high-grade intracranial arteriovenous malformations. Br J Neurosurg. 2014;28(5):666-674.
27. Ding D, Yen CP, Xu Z, et al. Radiosurgery for low-grade intracranial arteriovenous malformations. J Neurosurg. 2014;121(2):457-467.
28. Alomari A, Rauch PJ, Orsaria M, et al. Radiologic and histologic consequences of radiosurgery for brain tumors. J Neurooncol. 2014;117(1):33-42.
29. Linskey ME, Martinez AJ, Kondziolka D, et al. The radiobiology of human acoustic schwannoma xenografts after stereotactic radiosurgery evaluated in the subrenal capsule of athymic mice. J Neurosurg. 1993;78(4):645-653.
30. Niranjan A, Lunsford LD, Flickinger JC, et al. Dose reduction improves hearing preservation rates after intracanalicular acoustic tumor radiosurgery. Neurosurgery. 1999;45(4): 753-762, discussion 762-755.
31. Barker M, Deen DF, Baker DG. BCNU and X-ray therapy of intracerebral 9L rat tumors. Int J Radiat Oncol Biol Phys. 1979; 5(9):1581-1583.
32. Cohen JD, Robins HI, Javid MJ. Radiosensitization of C6 glioma by thymidine and 41.8 degrees C hyperthermia. J Neurosurg. 1990; 72(5):782-785.
33. Steinbok P, Mahaley MS Jr., varia MA, et al. Treatment of autochthonous rat brain tumors with fractionated radiotherapy. The effects of graded radiation doses and of combined therapy with BCNU or steroids. J Neurosurg. 1980;53(1):68-72.
34. Wheeler KT, Kaufman K. Influence of fractionation schedules on the response of a rat brain tumor to therapy with BCNU and radiation. Int J Radiat Oncol Biol Phys. 1980;6(7):845-849.
35. Yang X, Darling JL, McMillan TJ, et al. Radiosensitivity, recovery and dose-rate effect in three human glioma cell lines. Radiother Oncol. 1990;19(1):49-56.
36. Kondziolka D, Lunsford LD, Claassen D, et al. Radiobiology of radiosurgery: Part II. The rat C6 glioma model. Neurosurgery. 1992;31(2):280-287. discussion 287-288.
37. Kondziolka D, Somaza S, Comey C, et al. Radiosurgery and fractionated radiation therapy: comparison of different techniques in an in vivo rat glioma model. J Neurosurg. 1996; 84(6):1033-1038.
38. Cabrera AR, Cuneo KC, Desjardins A, et al. Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial. Int J Radiat Oncol Biol Phys. 2013;86(5):873-879.
39. Flickinger JC, Kondziolka D, Niranjan A, et al. Results of acoustic neuroma radiosurgery: an analysis of 5 years experience using current methods. J Neurosurg. 2001;94(1):1-6.
40. Subach BR, Kondziolka D, Lunsford LD, et al. Stereotactic radiosurgery in the management of acoustic neuromas associated with neurofibromatosis Type 1. J Neurosurg. 1999; 90(5):815-822.
41. Kondziolka D, Lunsford LD, McLaughlin MR, et al. Long-term outcomes after radiosurgery for acoustic neuromas. N Engl J Med. 1998;339(20):1426-1433.
42. Ahmed OH, Mahboubi H, Lahham S, et al. Trends in demographics, charges, and outcomes of patients undergoing excision of sporadic vestibular schwannoma. Otolaryngol Head Neck Surg. 2014;150(2):266-274.
43. Patel S, Nuno M, Mukherjee D, et al. Trends in surgical use and associated patient outcomes in the treatment of acoustic neuroma. World Neurosurg. 2013;80(1-2):142-147.
44. Kano H, Kondziolka D, Khan A, et al. Predictors of hearing preservation after stereotactic radiosurgery for acoustic neuroma. J Neurosurg. 2009;111(4):863-873.
45. Niranjan A, Mathieu D, Flickinger JC, et al. Hearing preservation after intracanalicular vestibular schwannoma radiosurgery. Neurosurgery. 2008;63(6):1054-1062. discussion 1062-1053.
46. Baschnagel AM, Chen PY, Bojrab D, et al. Hearing preservation in patients with vestibular schwannoma treated with Gamma Knife surgery. J Neurosurg. 2013;118(3):571-578.
47. Link MJ, Pollock BE. Chasing the Holy Grail of vestibular schwannoma management. World Neurosurg. 2013;80(3-4): 276-278.
48. Kopp C, Fauser C, Muller A, et al. Stereotactic fractionated radiotherapy and LINAC radiosurgery in the treatment of vestibular schwannoma-report about both stereotactic methods from a single institution. Int J Radiat Oncol Biol Phys. 2011;80(5):1485-1491.
49. Collen C, Ampe B, Gevaert T, et al. Single fraction versus fractionated linac-based stereotactic radiotherapy for vestibular schwannoma: a single-institution experience. Int J Radiat Oncol Biol Phys. 2011;81(4):e503-e509.
50. Henzel M, Hamm K, Sitter H, et al. Comparison of stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neurinomas according to 3-D tumor volume shrinkage and quality of life. Strahlenther Onkol. 2009;185(9):567-573.
51. Meijer OW, Vandertop WP, Baayen JC, et al. Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: a single-institution study. Int J Radiat Oncol Biol Phys. 2003;56(5):1390-1396.
52. Kim YH, Kim DG, Han JH, et al. Radiosurgery for para-IAC meningiomas: the effect of radiation dose to the cochlea on hearing outcome. Int J Radiat Oncol Biol Phys. 2012;84(3): 675-680.
53. Jacob JT, Carlson ML, Schiefer TK, et al. Significance of cochlear dose in the rRadiosurgical treatment of vestibular schwannoma: controversies and unanswered questions. Neurosurgery. 2014; 74(5):466-474.
54. Lasak JM, Klish D, Kryzer TC, et al. Gamma knife radiosurgery for vestibular schwannoma: early hearing outcomes and evaluation of the cochlear dose. Otol Neurotol. 2008;29(8):1179-1186.
55. Massager N, Nissim O, Delbrouck C, et al. Irradiation of cochlear structures during vestibular schwannoma radiosurgery and associated hearing outcome. J Neurosurg. 2007;107(4): 733-739.
56. Pacholke HD, Amdur RJ, Schmalfuss IM, et al. Contouring the middle and inner ear on radiotherapy planning scans. Am J Clin Oncol. 2005;28(2):143-147.
57. Lunsford LD, Niranjan A, Flickinger JC, et al. Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg. 2005;102(Suppl):195-199.
58. Roos DE, Potter AE, Brophy BP. Stereotactic radiosurgery for acoustic neuromas: what happens long term?. Int J Radiat Oncol Biol Phys. 2012;82(4):1352-1355.
59. Carlson ML, Jacob JT, Pollock BE, et al. Long-term hearing outcomes following stereotactic radiosurgery for vestibular schwannoma: patterns of hearing loss and variables influencing audiometric decline. J Neurosurg. 2013;118(3):579-587.
60. Yomo S, Carron R, Thomassin JM, et al. Longitudinal analysis of hearing before and after radiosurgery for vestibular schwannoma. J Neurosurg. 2012;117(5):877-885.
61. Lobato-Polo J, Kondziolka D, Zorro O, et al. Gamma knife radiosurgery in younger patients with vestibular schwannomas. Neurosurgery. 2009;65(2):294-300, discussion 300-291.
62. Chee GH, Nedzelski JM, Rowed D. Acoustic neuroma surgery: the results of long-term hearing preservation. Otol Neurotol. 2003; 24(4):672-676.
63. Pollock BE, Driscoll CL, Foote RL, et al. Patient outcomes after vestibular schwannoma management: a prospective comparison of microsurgical resection and stereotactic radiosurgery. Neurosurgery. 2006;59(1):77-85. discussion 77-85.
64. Friedman WA, Bradshaw P, Myers A, et al. Linear accelerator radiosurgery for vestibular schwannomas. J Neurosurg. 2006; 105(5):657-661.
65. Hayashi M, Chernov MF, Lipski SM, et al. Do we really still need an open surgery for treatment of patients with vestibular schwannomas?. Acta Neurochir Suppl. 2013;116:25-36.
66. Flickinger JC, Kondziolka D, Niranjan A, et al. Acoustic neuroma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2004;60(1):225-230.
67. Yanamadala V, Williamson RW, Fusco DJ, et al. Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery. World Neurosurg. 2013;79(3-4):593 e591-598.
68. Demetriades AK, Saunders N, Rose P, et al. Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery. Skull Base. 2010;20(5):381-387.
69. Kondziolka D, Mousavi SH, Kano H, et al. The newly diagnosed vestibular schwannoma: radiosurgery, resection, or observation?. Neurosurg Focus. 2012;33(3):E8.
70. Myrseth E, Moller P, Pedersen PH, et al. Vestibular schwannomas: clinical results and quality of life after microsurgery or gamma knife radiosurgery. Neurosurgery. 2005;56(5):927-935, discussion 927-935.
71. Inoue HK. Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J eurosurg. 2005;102(Suppl):111-113.
72. Hasegawa T, Kida Y, Kobayashi T, et al. Long-term outcomes in patients with vestibular schwannomas treated using gamma knife surgery: 10-year follow up. J Neurosurg. 2005;102(1): 10-16.
73. Chung WY, Liu KD, Shiau CY, et al. Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg. 2005;102:(Suppl):87-96.
74. Kondziolka D, Lunsford LD, Flickinger JC. Acoustic neuroma radiosurgery. Origins, contemporary use and future expectations. Neurochirurgie. 2004;50(2-3 Pt 2):427-435.
75. Ishihara H, Saito K, Nishizaki T, et al. CyberKnife radiosurgery for vestibular schwannoma. Minim Invasive Neurosurg. 2004;47(5): 290-293.
76. Kondziolka D, Nathoo N, Flickinger JC, et al. Long-term results after radiosurgery for benign intracranial tumors. Neurosurgery. 2003;53(4):815-821, discussion 821-812.
77. Delbrouck C, Hassid S, Massager N, et al. Preservation of hearing in vestibular schwannomas treated by radiosurgery using Leksell Gamma Knife: preliminary report of a prospective Belgian clinical study. Acta Otorhinolaryngol Belg. 2003;57(3):197-204.
78. Karpinos M, Teh BS, Zeck O, et al. Treatment of acoustic neuroma: stereotactic radiosurgery vs. microsurgery. Int J Radiat Oncol Biol Phys. 2002;54(5):1410-1421.
79. Horstmann GA, Van Eck AT. Gamma knife model C with the automatic positioning system and its impact on the treatment of vestibular schwannomas. J Neurosurg. 2002;97(5 Suppl): 450-455.
80. Petit JH, Hudes RS, Chen TT, et al. Reduced-dose radiosurgery for vestibular schwannomas. Neurosurgery. 2001;49(6):1299-1306, discussion 1306-1297.
81. Maesawa S, Kondziolka D, Thompson TP, et al. Brain metastases in patients with no known primary tumor. Cancer. 2000;89(5): 1095-1101.
82. Fuss M, Debus J, Lohr F, et al. Conventionally fractionated stereotactic radiotherapy (FSRT) for acoustic neuromas. Int J Radiat Oncol Biol Phys. 2000;48(5):1381-1387.
83. Flickinger JC, Kondziolka D, Pollock BE, et al. Evolution in technique for vestibular schwannoma radiosurgery and effect on outcome. Int J Radiat Oncol Biol Phys. 1996;36(2):275-280.
84. Pollock BE, Lunsford LD, Kondziolka D, et al. Outcome analysis of acoustic neuroma management: a comparison of microsurgery and stereotactic radiosurgery. Neurosurgery. 1995;36(1): 215-224, discussion 224-219.
85. Regis J, Carron R, Park MC, et al.Wait-and-see strategy compared with proactive Gamma Knife surgery in patients with intracanalicular vestibular schwannomas. J Neurosurg. 2010; 113(Suppl):105-111.
86. Regis J, Pellet W, Delsanti C, et al. Functional outcome after gamma knife surgery or microsurgery for vestibular schwannomas. J Neurosurg. 2002;97(5):1091-1100.
87. Zeiler FA, Bigder M, Kaufmann A, et al. Gamma knife radiosurgery for large vestibular schwannomas: a Canadian experience. Can J Neurol Sci. 2013;40(3):342-347.
88. Pollock BE. Management of vestibular schwannomas that enlarge after stereotactic radiosurgery: treatment recommendations based on a 15 year experience. Neurosurgery. 2006;58(2):241-248, discussion 241-248.
89. Hasegawa T, Kida Y, Yoshimoto M, et al. Evaluation of tumor expansion after stereotactic radiosurgery in patients harboring vestibular schwannomas. Neurosurgery. 2006;58(6): 1119-1128, discussion 1119-1128.
90. Nakaya K, Niranjan A, Kondziolka D, et al. Gamma knife radiosurgery for benign tumors with symptoms from brainstem compression. Int J Radiat Oncol Biol Phys. 2010; 77(4):988-995.
91. Yang HC, Kano H, Awan NR, et al. Gamma Knife radiosurgery for larger-volume vestibular schwannomas. Clinical article. J Neurosurg. 2011;114(3):801-807.
92. Williams BJ, Xu Z, Salvetti DJ, et al. Gamma Knife surgery for large vestibular schwannomas: a single-center retrospective case-matched comparison assessing the effect of lesion size. J Neurosurg. 2013;119(2):463-471.
93. Hansasuta A, Choi CY, Gibbs IC, et al. Multisession stereotactic radiosurgery for vestibular schwannomas: single-institution experience with 383 cases. Neurosurgery. 2011;69(6):1200-1209.
94. Chung HT, Ma R, Toyota B, et al. Audiologic and treatment outcomes after linear accelerator-based stereotactic irradiation for acoustic neuroma. Int J Radiat Oncol Biol Phys. 2004;59(4): 1116-1121.
95. Sawamura Y, Shirato H, Sakamoto T, et al. Management of vestibular schwannoma by fractionated stereotactic radiotherapy and associated cerebrospinal fluid malabsorption. J Neurosurg. 2003;99(4):685-692.
96. Champ CE, Shen X, Shi W, et al. Reduced-dose fractionated stereotactic radiotherapy for acoustic neuromas: maintenance of tumor control with improved hearing preservation. Neurosurgery. 2013;73(3):489-496.
97. Kondziolka D, Mathieu D, Lunsford LD, et al. Radiosurgery as definitive management of intracranial meningiomas. Neurosurgery. 2008;62(1):53-58, discussion 58-60.
98. Kondziolka D, Levy EI, Niranjan A, et al. Long-term outcomes after meningioma radiosurgery: physician and patient perspectives. J Neurosurg. 1999;91(1):44-50.
99. Lall RR, Lall RR, Smith TR, et al. Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery. J Clin Neurosci. 2014;21(7):1225-1228.
100. Lee HS, Kim JH, Lee JI. Glioblastoma following radiosurgery for meningioma. J Korean Neurosurg Soc. 2012;51(2):98-101.
101. Kondziolka D, Madhok R, Lunsford LD, et al. Stereotactic radiosurgery for convexity meningiomas. J Neurosurg. 2009; 111(3):458-463.
102. Flannery TJ, Kano H, Lunsford LD, et al. Long-term control of petroclival meningiomas through radiosurgery. J Neurosurg. 2010;112(5):957-964.
103. Zenonos G, Kondziolka D, Flickinger JC, et al. Gamma Knife surgery in the treatment paradigm for foramen magnum meningiomas. J Neurosurg. 2012;117(5):864-873.
104. Ding D, Xu Z, McNeill IT, et al. Radiosurgery for parasagittal and parafalcine meningiomas. J Neurosurg. 2013;119(4):871-877.
105. Lee JY, Niranjan A, McInerney J, et al. Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomas. J Neurosurg. 2002;97(1):65-72.
106. Condra KS, Buatti JM, Mendenhall WM, et al. Benign meningiomas: primary treatment selection affects survival. Int J Radiat Oncol Biol Phys. 1997;39(2):427-436.
107. Coke CC, Corn BW,Werner-Wasik M, et al. Atypical and malignant meningiomas: an outcome report of seventeen cases. J Neurooncol. 1998;39(1):65-70.
108. Hug EB, Devries A, Thornton AF, et al. Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neurooncol. 2000;48(2):151-160.
109. Sheehan JP, Niranjan A, Sheehan JM, et al. Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. J Neurosurg. 2005;102(4):678-691.
110. Killory BD, Kresl JJ, Wait SD, et al. Hypofractionated CyberKnife radiosurgery for perichiasmatic pituitary adenomas: early results. Neurosurgery. 2009;64(2 Suppl):A19-A25.
111. Sheehan JP, Starke RM, Mathieu D, et al. Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg. 2013;119(2): 446-456.
112. Mingione V, Yen CP, Vance ML, et al. Gamma surgery in the treatment of nonsecretory pituitary macroadenoma. J Neurosurg. 2006;104(6):876-883.
113. Sheehan JP, Xu Z, Salvetti DJ, et al. Results of gamma knife surgery for Cushings disease. J Neurosurg. 2013;119(6): 1486-1492.
114. Liu X, Kano H, Kondziolka D, et al. Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas. Pituitary. 2013;16(1):68-75.
115. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363(9422): 1665-1672.
116. Atteberry D, Szeifert G, Kondziolka D, et al. Radiosurgical pathology observations on cerebral metastases after gamma knife radiosurgery. Radiosurgery. 2006;6:173-185.
117. Bhatnagar AK, Flickinger JC, Kondziolka D, et al. Stereotactic radiosurgery for four or more intracranial metastases. Int J Radiat Oncol Biol Phys. 2006;64(3):898-903.
118. Firlik KS, Kondziolka D, Flickinger JC, et al. Stereotactic radiosurgery for brain metastases from breast cancer. Ann Surg Oncol. 2000;7(5):333-338.
119. Flickinger JC, Kondziolka D. Radiosurgery instead of resection for solitary brain metastasis: the gold standard redefined. Int J Radiat Oncol Biol Phys. 1996;35(1):185-186.
120. Hasegawa T, Kondziolka D, Flickinger JC, et al. Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy?. Neurosurgery. 2003;52(6):1318-1326, discussion 1326.
121. Hasegawa T, Kondziolka D, Flickinger JC, et al. Stereotactic radiosurgery for brain metastases from gastrointestinal tract cancer. Surg Neurol. 2003;60(6):506-514, discussion 514-505.
122. Kondziolka D, Martin JJ, Flickinger JC, et al. Long-term survivors after gamma knife radiosurgery for brain metastases. Cancer. 2005;104(12):2784-2791.
123. Mori Y, Kondziolka D, Flickinger JC, et al. Stereotactic radiosurgery for cerebral metastatic melanoma: factors affecting local disease control and survival. Int J Radiat Oncol Biol Phys. 1998; 42(3):581-589.
124. Mori Y, Kondziolka D, Flickinger JC, et al. Stereotactic radiosurgery for brain metastasis from renal cell carcinoma. Cancer. 1998; 83(2):344-353.
125. Peterson AM, Meltzer CC, Evanson EJ, et al. MR imaging response of brain metastases after gamma knife stereotactic radiosurgery. Radiology. 1999;211(3):807-814.
126. Sheehan JP, Sun MH, Kondziolka D, et al. Radiosurgery in patients with renal cell carcinoma metastasis to the brain: long-term outcomes and prognostic factors influencing survival and local tumor control. J Neurosurg. 2003;98(2):342-349.
127. Chang EL,Wefel JS, Maor MH, et al. A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone. Neurosurgery. 2007;60(2):277-283, discussion 283-274.
128. Kondziolka D, Niranjan A, Flickinger JC, et al. Radiosurgery with or without whole-brain radiotherapy for brain metastases: the patients perspective regarding complications. Am J Clin Oncol. 2005;28(2):173-179.
129. Gondi V, Hermann BP, Mehta MP, et al. Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Oncol Biol Phys. 2013;85(2):348-354.
130. Gondi V, Tolakanahalli R, Mehta MP, et al. Hippocampal-sparing whole-brain radiotherapy: a how-to technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2010;78(4): 1244-1252.
131. Gondi V, Tome WA, Mehta MP. Why avoid the hippocampus? A comprehensive review. Radiother Oncol. 2010;97(3):370-376.
132. Roberge D, Parker W, Niazi TM, et al. Treating the contents and not the container: dosimetric study of hair-sparing whole brain intensity modulated radiation therapy. Technol Cancer Res Treat. 2005;4(5):567-570.
133. Welsh JS, Mehta MP, Mackie TR, et al. Helical tomotherapy as a means of delivering scalp-sparing whole brain radiation therapy. Technol Cancer Res Treat. 2005;4(6):661-662, author reply 11
134. Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 1990;322(8):494-500.
135. Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA. 1998;280(17):1485-1489.
136. Aoyama H, Shirato H, Tago M, et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA. 2006;295(21):2483-2491.
137. Chang EL, Wefel JS, Hess KR, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009;10(11):1037-1044.
138. Mathieu D, Kondziolka D, Cooper PB, et al. Gamma knife radiosurgery in the management of malignant melanoma brain metastases. Neurosurgery. 2007;60(3):471-481, discussion 481-472.
139. Shaw E, Scott C, Souhami L, et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47(2):291-298.
140. Manon R, ONeill A, Knisely J, et al. Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397). J Clin Oncol. 2005; 23(34):8870-8876.
141. Truman JP, Garcia-Barros M, Kaag M, et al. Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PloS One. 2010; 5(9). doi: 10.1371/ annotation/6e222ad5-b175-4a00-9d04-4d120568a897.
142. Garcia-Barros M, Paris F, Cordon-Cardo C, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003;300(5622):1155-1159.
143. Brown JM, Carlson DJ, Brenner DJ. The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?. Int J Radiat Oncol Biol Phys. 2014;88(2):254-262.
144. Grandhi R, Kondziolka D, Panczykowski D, et al. Stereotactic radiosurgery using the Leksell Gamma Knife Perfexion unit in the management of patients with 10 or more brain metastases. J Neurosurg. 2012;117(2):237-245.
145. Yamamoto M, Serizawa T, Shuto T, et al. Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol. 2014;15(4):387-395.
146. Monaco EA 3rd, Faraji AH, Berkowitz O, et al. Leukoencephalopathy after whole-brain radiation therapy plus radiosurgery versus radiosurgery alone for metastatic lung cancer. Cancer. 2013;119(1):226-232.
147. Luther N, Kondziolka D, Kano H, et al. Predicting tumor control after resection bed radiosurgery of brain metastases. Neurosurgery. 2013;73(6):1001-1006, discussion 1006.
148. Gans JH, Raper DM, Shah AH, et al. The role of radiosurgery to the tumor bed after resection of brain metastases. Neurosurgery. 2013;72(3):317-325, discussion 325-316.
149. Brennan C, Yang TJ, Hilden P, et al. A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases. Int J Radiat Oncol Biol Phys. 2014;88(1):130-136.
150. Mehta M, Noyes W, Craig B, et al. A cost-effectiveness and cost-utility analysis of radiosurgery vs. resection for single-brain metastases. Int J Radiat Oncol Biol Phys. 1997;39(2):445-454.
151. Lee WY, Cho DY, Lee HC, et al. Outcomes and cost-effectiveness of gamma knife radiosurgery and whole brain radiotherapy for multiple metastatic brain tumors. J Clin Neurosci. 2009;16(5): 630-634.
152. Kondziolka D, Patel A, Lunsford LD, et al. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45(2):427-434.
153. Kurtz G, Zadeh G, Gingras-Hill G, et al. Salvage radiosurgery for brain metastases: prognostic factors to consider in patient selection. Int J Radiat Oncol Biol Phys. 2014;88(1):137-142.
154. Gaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 1997;37(4):745-751.
155. Sperduto PW, Chao ST, Sneed PK, et al. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys. 2010;77(3):655-661.
156. Kondziolka D, Parry PV, Lunsford LD, et al. The accuracy of predicting survival in individual patients with cancer. J Neurosurg. 2014;120(1):24-30.
157. Linskey ME, Andrews DW, Asher AL, et al. The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010; 96(1):45-68.
158. Kondziolka D, Kano H, Harrison GL, et al. Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer. Clinical article. J Neurosurg. 2011;114(3):792-800.
159. Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncology. 2009;10(5):459-466.
160. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-996.
161. Kondziolka D, Flickinger JC, Bissonette DJ, et al. Survival benefit of stereotactic radiosurgery for patients with malignant glial neoplasms. Neurosurgery. 1997;41(4):776-783, discussion 783-775.
162. Souhami L, Seiferheld W, Brachman D, et al. Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol. Int J Radiat Oncol Biol Phys. 2004;60(3):853-860.
163. Tanaka S, Shin M, Mukasa A, et al. Stereotactic radiosurgery for intracranial gliomas. Neurosurg Clin N Am. 2013;24(4):605-612.
164. Gorski DH, Beckett MA, Jaskowiak NT, et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 1999; 59(14):3374-3378.
165. Park KJ, Kano H, Iyer A, et al. Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study. J Neurooncol. 2012;107(2):323-333.
166. Cuneo KC, Vredenburgh JJ, Sampson JH, et al. Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2012;82(5):2018-2024.
167. McGirt MJ, Chaichana KL, Attenello FJ, et al. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008;63(4):700-707, author reply 707-708.
168. Smith JS, Chang EF, Lamborn KR, et al. Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 2008;26(8):1338-1345.
169. Heppner PA, Sheehan JP, Steiner LE. Gamma knife surgery for low-grade gliomas. Neurosurgery. 2008;62(Suppl 2):755-762.
170. Kano H, Kondziolka D, Niranjan A, et al. Stereotactic radiosurgery for pilocytic astrocytomas part 1: outcomes in adult patients. J Neurooncol. 2009;95(2):211-218.
171. Park KJ, Kano H, Kondziolka D, et al. Early or delayed radiosurgery for WHO grade II astrocytomas. J Neurooncol. 2011;103(3): 523-532.
172. Kano H, Niranjan A, Kondziolka D, et al. Stereotactic radiosurgery for pilocytic astrocytomas part 2: outcomes in pediatric patients. J Neurooncol. 2009;95(2):219-229.
173. Mansur DB, Drzymala RE, Rich KM, et al. The efficacy of stereotactic radiosurgery in the management of intracranial ependymoma. J Neurooncol. 2004;66(1-2):187-190.
174. Kano H, Niranjan A, Kondziolka D, et al. Outcome predictors for intracranial ependymoma radiosurgery. Neurosurgery. 2009; 64(2):279-287, discussion 287-278.
175. Kano H, Yang HC, Kondziolka D, et al. Stereotactic radiosurgery for pediatric recurrent intracranial ependymomas. J Neurosurg Pediatr. 2010;6(5):417-423.
176. Lo SS, Chang EL, Sloan AE. Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in the management of intracranial ependymoma. Expert Rev Neurother. 2006;6(4): 501-507.
177. Healey EA, Barnes PD, Kupsky WJ, et al. The prognostic significance of postoperative residual tumor in ependymoma. Neurosurgery. 1991;28(5):666-671, discussion 671-662.
178. Horn B, Heideman R, Geyer R, et al. A multi-institutional retrospective study of intracranial ependymoma in children: identification of risk factors. J Pediatr Hematol Oncol. 1999; 21(3):203-211.
179. Pollack IF, Gerszten PC, Martinez AJ, et al. Intracranial ependymomas of childhood: long-term outcome and prognostic factors. Neurosurgery. 1995;37(4):655-666, discussion 666-657.
180. Robertson PL, Zeltzer PM, Boyett JM, et al. Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Childrens Cancer Group. J Neurosurg. 1998;88(4):695-703.
181. Krieger MD, McComb JG. The role of stereotactic radiotherapy in the management of ependymomas. Childs Nerv Syst. 2009; 25(10):1269-1273.
182. Stauder MC, Ni Laack N, Ahmed KA, et al. Stereotactic radiosurgery for patients with recurrent intracranial ependymomas. J Neurooncol. 2012;108(3):507-512.
183. Hodgson DC, Goumnerova LC, Loeffler JS, et al. Radiosurgery in the management of pediatric brain tumors. Int J Radiat Oncol Biol Phys. 2001;50(4):929-935.
184. Lo SS, Abdulrahman R, Desrosiers PM, et al. The role of Gamma Knife Radiosurgery in the management of unresectable gross disease or gross residual disease after surgery in ependymoma. J Neurooncol. 2006;79(1):51-56.
185. Merchant TE, Boop FA, Kun LE, et al. A retrospective study of surgery and reirradiation for recurrent ependymoma. Int J Radiat Oncol Biol Phys. 2008;71(1):87-97.
186. Stafford SL, Pollock BE, Foote RL, et al. Stereotactic radiosurgery for recurrent ependymoma. Cancer. 2000;88(4):870-875.
187. Niranjan A, Kano H, Mathieu D, et al. Radiosurgery for craniopharyngioma. Int J RadiatOncol Biol Phys. 2010;78(1):64-71.
188. Suh JH, Gupta N. Role of radiation therapy and radiosurgery in the management of craniopharyngiomas. Neurosurg Clin N Ama. 2006;17(2):143-148, vi-vii.
189. Kobayashi T, Tanaka T, Kida Y. Stereotactic gamma radiosurgery of craniopharyngiomas. Pediatr Neurosurg. 1994;21(Suppl 1):69-74.
190. Veeravagu A, Lee M, Jiang B, et al. The role of radiosurgery in the treatment of craniopharyngiomas. Neurosurg Focus. 2010;28(4): E11.
191. Chiou SM, Lunsford LD, Niranjan A, et al. Stereotactic radiosurgery of residual or recurrent craniopharyngioma, after surgery, with or without radiation therapy. Neuro Oncol. 2001; 3(3):159-166.
192. Kobayashi T, Kida Y, Mori Y, et al. Long-term results of gamma knife surgery for the treatment of craniopharyngioma in 98 consecutive cases. J Neurosurg Pediatr. 2005;103(6):482-488.
193. Mokry M. Craniopharyngiomas: A six year experience with Gamma Knife radiosurgery. Stereotact Funct Neurosurg. 1999; 72(Suppl 1):140-149.
194. Xu Z, Yen CP, Schlesinger D, et al. Outcomes of Gamma Knife surgery for craniopharyngiomas. J Neurooncol. 2011;104(1): 305-313.
195. Chung WY, Pan DH, Shiau CY, et al. Gamma knife radiosurgery for craniopharyngiomas. J Neurosurg. 2000;93(Suppl 3):47-56.
196. Gopalan R, Dassoulas K, Rainey J, et al. Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas. Neurosurg Focus. 2008;24(5):E5.
197. Minniti G, Esposito V, Amichetti M, et al. The role of fractionated radiotherapy and radiosurgery in the management of patients with craniopharyngioma. Neurosurgl Rev. 2009;32(2):125-132.
198. Hasegawa T, Kobayashi T, Kida Y. Tolerance of the optic apparatus in single-fraction irradiation using stereotactic radiosurgery: evaluation in 100 patients with craniopharyngioma. Neurosurgery. 2010;66(4):688-694, discussion 694-685.
199. Leber KA, Bergloff J, Pendl G. Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery. J Neurosurg. 1998;88(1):43-50.
200. Tishler RB, Loeffler JS, Lunsford LD, et al. Tolerance of cranial nerves of the cavernous sinus to radiosurgery. Int J Radiat Oncol Biol Phys. 1993;27(2):215-221.
201. Lee M, Kalani MY, Cheshier S, et al. Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas. Neurosurg Focus. 2008;24(5):E4.
202. Iwata H, Tatewaki K, Inoue M, et al. Single and hypofractionated stereotactic radiotherapy with CyberKnife for craniopharyngioma. J Neurooncol. 2012;106(3):571-577.