Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1

Immunology

Volumn 144, Issue 2, 2015, Pages 312-320

  Yeon, Sang Hyeon ^a   Song, Moon Jung ^b   Kang, Hye Ri ^b   Lee, Joo Young ^a  

^a The Catholic University of Korea   (South Korea)

^b Korea University   (South Korea)

Author keywords

Innate immunity; Macrophages; Pattern recognition receptor; Type I interferon; Virus infection

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADAPTOR PROTEIN; BETA INTERFERON; CASPASE; INTERFERON BETA PROMOTER STIMULATOR 1; INTERFERON REGULATORY FACTOR 3; PATTERN RECOGNITION RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLECKSTRIN; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE B; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANTIVIRUS AGENT; CHROMONE DERIVATIVE; DDX58 PROTEIN, MOUSE; DEAD BOX PROTEIN; ENZYME INHIBITOR; INTERFERON INDUCING AGENT; IPS-1 PROTEIN, MOUSE; IRF3 PROTEIN, MOUSE; MORPHOLINE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENDAI VIRUS; SENDAI VIRUS INFECTION; SIGNAL TRANSDUCTION; VIRUS IMMUNITY; VIRUS INFECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; ENZYME ACTIVATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; RESPIROVIRUS INFECTION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; CHROMONES; DEAD-BOX RNA HELICASES; DIMERIZATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; INTERFERON INDUCERS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; POLY I-C; PROTO-ONCOGENE PROTEINS C-AKT; RESPIROVIRUS INFECTIONS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SENDAI VIRUS; SIGNAL TRANSDUCTION;

EID: 84922573027     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12373     Document Type: Article

References (16)

1. Kato H, Takahasi K, Fujita T. RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol Rev 2011; 243:91-8.
2. Kato H, Sato S, Yoneyama M et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005; 23:19-28.
3. Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006; 441:101-5.
4. Yoneyama M, Kikuchi M, Natsukawa T et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004; 5:730-7.
5. Kawai T, Takahashi K, Sato S et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6:981-8.
6. Saha SK, Pietras EM, He JQ et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J 2006; 25:3257-63.
7. Schabbauer G, Luyendyk J, Crozat K, Jiang Z, Mackman N, Bahram S, Georgel P. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol 2008; 45:2790-6.
8. Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY. Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol 2011; 186:499-507.
9. Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 2004; 11:1060-7.
10. Hrincius ER, Dierkes R, Anhlan D, Wixler V, Ludwig S, Ehrhardt C. Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production. Cell Microbiol 2011; 13:1907-19.
11. Kim SY, Koo JE, Seo YJ et al. Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2. Br J Pharmacol 2013; 168:1933-45.
12. Kato H, Takeuchi O, Mikamo-Satoh E et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008; 205:1601-10.
13. Jeong E, Koo JE, Yeon SH, Kwak MK, Hwang DH, Lee JY. PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. Mol Carcinog 2014, doi: 10.1002/mc.22144.
14. Kim SY, Koo JE, Song MR, Lee JY. Retinol suppresses the activation of Toll-like receptors in MyD88- and STAT1-independent manners. Inflammation 2013; 36:426-33.
15. Zhirnov OP, Konakova TE, Wolff T, Klenk HD. NS1 protein of influenza A virus down-regulates apoptosis. J Virol 2002; 76:1617-25.
16. White CL, Chattopadhyay S, Sen GC. Phosphatidylinositol 3-kinase signaling delays Sendai virus-induced apoptosis by preventing XIAP degradation. J Virol 2011; 85:5224-7.