Metformin ameliorates β-cell dysfunction by regulating inflammation production, ion and hormone homeostasis of pancreas in diabetic KKAy mice

Yaoxue Xuebao

Volumn 49, Issue 11, 2014, Pages 1554-1562

  Liu, Shuai Nan ^a   Liu, Quan ^a   Sun, Su Juan ^a   Hou, Shao Cong ^a   Wang, Yue ^a   Shen, Zhu Fang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Diabetic KKAy mice; Inflammation; Ion homeostasis; Metformin; cell function

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM MAGNESIUM); GLUCAGON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 6; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; METFORMIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SIRTUIN 5; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HORMONE HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; ION HOMEOSTASIS; MOUSE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PANCREATITIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; INFLAMMATION; METABOLISM; SECRETION (PROCESS);

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; FEMALE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTERLEUKIN-6; METFORMIN; MICE; NF-KAPPA B; PANCREAS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84922568426     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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