-
2
-
-
8144228952
-
Friends or foes - bipolar effects of the tumour stroma in cancer
-
Mueller MM, Fusenig NE. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004;4:839-49.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 839-849
-
-
Mueller, M.M.1
Fusenig, N.E.2
-
3
-
-
80155192769
-
HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers
-
Murata T, Mizushima H, Chinen I et al. HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers. Cancer Res 2011;71:6633-42.
-
(2011)
Cancer Res
, vol.71
, pp. 6633-6642
-
-
Murata, T.1
Mizushima, H.2
Chinen, I.3
-
4
-
-
79952712906
-
Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression
-
Wu MH, Hong HC, Hong TM, Chiang WF, Jin YT, Chen YL. Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression. Clin Cancer Res 2011;17:1306-16.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1306-1316
-
-
Wu, M.H.1
Hong, H.C.2
Hong, T.M.3
Chiang, W.F.4
Jin, Y.T.5
Chen, Y.L.6
-
5
-
-
71549136169
-
Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ
-
Jedeszko C, Victor BC, Podgorski I, Sloane BF. Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Res 2009;69:9148-55.
-
(2009)
Cancer Res
, vol.69
, pp. 9148-9155
-
-
Jedeszko, C.1
Victor, B.C.2
Podgorski, I.3
Sloane, B.F.4
-
6
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumour growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
Orimo A, Gupta PB, Sgroi DC et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumour growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005;121:335-48.
-
(2005)
Cell
, vol.121
, pp. 335-348
-
-
Orimo, A.1
Gupta, P.B.2
Sgroi, D.C.3
-
7
-
-
84897506018
-
Regulation of the anti-tumour immune response by cancer associated fibroblasts
-
Harper J, Sainson RC. Regulation of the anti-tumour immune response by cancer associated fibroblasts. Semin Cancer Biol 2014;25:69-77.
-
(2014)
Semin Cancer Biol
, vol.25
, pp. 69-77
-
-
Harper, J.1
Sainson, R.C.2
-
8
-
-
33847384529
-
FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis
-
Kobayashi N, Hiraoka N, Yamagami W et al. FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 2007;13:902-11.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 902-911
-
-
Kobayashi, N.1
Hiraoka, N.2
Yamagami, W.3
-
9
-
-
77949266099
-
CD8+CD28- cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients
-
Karagöz B, Bilgi O, Gümüs M et al. CD8+CD28- cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients. Med Oncol 2010;27:29-33.
-
(2010)
Med Oncol
, vol.27
, pp. 29-33
-
-
Karagöz, B.1
Bilgi, O.2
Gümüs, M.3
-
10
-
-
70350133511
-
IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients
-
Mandruzzato S, Solito S, Falisi E et al. IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients. J Immunol 2009;182:6562-8.
-
(2009)
J Immunol
, vol.182
, pp. 6562-6568
-
-
Mandruzzato, S.1
Solito, S.2
Falisi, E.3
-
11
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel TJ, Coukos G, Zou L et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-9.
-
(2004)
Nat Med
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
Coukos, G.2
Zou, L.3
-
12
-
-
46049098560
-
A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells
-
Hoechst B, Ormandy LA, Ballmaier M et al. A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells. Gastroenterology 2008;135:234-43.
-
(2008)
Gastroenterology
, vol.135
, pp. 234-243
-
-
Hoechst, B.1
Ormandy, L.A.2
Ballmaier, M.3
-
13
-
-
0036187615
-
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
-
Bingle L, Brown NJ, Lewis CE. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002;196:254-65.
-
(2002)
J Pathol
, vol.196
, pp. 254-265
-
-
Bingle, L.1
Brown, N.J.2
Lewis, C.E.3
-
14
-
-
0028286026
-
Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
-
Scanlan MJ, Raj BK, Calvo B et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci USA 1994;91:5657-61.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5657-5661
-
-
Scanlan, M.J.1
Raj, B.K.2
Calvo, B.3
-
15
-
-
78049442950
-
Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model
-
Wen Y, Wang CT, Ma TT et al. Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model. Cancer Sci 2010;101:2325-32.
-
(2010)
Cancer Sci
, vol.101
, pp. 2325-2332
-
-
Wen, Y.1
Wang, C.T.2
Ma, T.T.3
-
16
-
-
33745837774
-
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
-
Loeffler M, Krüger JA, Niethammer AG, Reisfeld RA. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J Clin Invest 2006;116:1955-62.
-
(2006)
J Clin Invest
, vol.116
, pp. 1955-1962
-
-
Loeffler, M.1
Krüger, J.A.2
Niethammer, A.G.3
Reisfeld, R.A.4
-
17
-
-
70949103794
-
Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model
-
Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA. Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS ONE 2009;4:e7965.
-
(2009)
PLoS ONE
, vol.4
, pp. e7965
-
-
Liao, D.1
Luo, Y.2
Markowitz, D.3
Xiang, R.4
Reisfeld, R.A.5
-
18
-
-
28244447726
-
Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts
-
Lee J, Fassnacht M, Nair S, Boczkowski D, Gilboa E. Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. Cancer Res 2005;65:11156-63.
-
(2005)
Cancer Res
, vol.65
, pp. 11156-11163
-
-
Lee, J.1
Fassnacht, M.2
Nair, S.3
Boczkowski, D.4
Gilboa, E.5
-
19
-
-
84880656055
-
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
-
Tran E, Chinnasamy D, Yu Z et al. Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J Exp Med 2013;210:1125-35.
-
(2013)
J Exp Med
, vol.210
, pp. 1125-1135
-
-
Tran, E.1
Chinnasamy, D.2
Yu, Z.3
-
20
-
-
0026485606
-
Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages
-
Suzawa H, Kikuchi S, Ichikawa K, Koda A. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages. Jpn J Pharmacol 1992;60:85-90.
-
(1992)
Jpn J Pharmacol
, vol.60
, pp. 85-90
-
-
Suzawa, H.1
Kikuchi, S.2
Ichikawa, K.3
Koda, A.4
-
21
-
-
4444263309
-
Inhibition by tranilast of nifedipine-induced proliferation of cultured human gingival fibroblasts
-
Hattori T, Wang PL. Inhibition by tranilast of nifedipine-induced proliferation of cultured human gingival fibroblasts. Eur J Pharmacol 2004;498:79-81.
-
(2004)
Eur J Pharmacol
, vol.498
, pp. 79-81
-
-
Hattori, T.1
Wang, P.L.2
-
22
-
-
0036386979
-
Effect of tranilast on proliferation, collagen gel contraction, and transforming growth factor beta secretion of retinal pigment epithelial cells and fibroblasts
-
Yasukawa T, Kimura H, Dong J et al. Effect of tranilast on proliferation, collagen gel contraction, and transforming growth factor beta secretion of retinal pigment epithelial cells and fibroblasts. Ophthalmic Res 2002;34:206-12.
-
(2002)
Ophthalmic Res
, vol.34
, pp. 206-212
-
-
Yasukawa, T.1
Kimura, H.2
Dong, J.3
-
23
-
-
0034028237
-
Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts
-
Isaji M, Kikuchi S, Miyata H et al. Inhibitory effects of tranilast on the proliferation and functions of human pterygium-derived fibroblasts. Cornea 2000;19:364-8.
-
(2000)
Cornea
, vol.19
, pp. 364-368
-
-
Isaji, M.1
Kikuchi, S.2
Miyata, H.3
-
24
-
-
0033934320
-
Tranilast inhibits cell proliferation and collagen synthesis by rabbit corneal and Tenon's capsule fibroblasts
-
Oshima T, Kurosaka D, Kato K et al. Tranilast inhibits cell proliferation and collagen synthesis by rabbit corneal and Tenon's capsule fibroblasts. Curr Eye Res 2000;20:283-6.
-
(2000)
Curr Eye Res
, vol.20
, pp. 283-286
-
-
Oshima, T.1
Kurosaka, D.2
Kato, K.3
-
25
-
-
0026452457
-
The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts
-
Suzawa H, Kikuchi S, Arai N, Koda A. The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol 1992;60:91-6.
-
(1992)
Jpn J Pharmacol
, vol.60
, pp. 91-96
-
-
Suzawa, H.1
Kikuchi, S.2
Arai, N.3
Koda, A.4
-
26
-
-
0036288203
-
Anti-tumor effect of N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) on experimental pancreatic cancer
-
Hiroi M, Onda M, Uchida E, Aimoto T. Anti-tumor effect of N-[3, 4-dimethoxycinnamoyl]-anthranilic acid (tranilast) on experimental pancreatic cancer. J Nippon Med Sch 2002;69:224-34.
-
(2002)
J Nippon Med Sch
, vol.69
, pp. 224-234
-
-
Hiroi, M.1
Onda, M.2
Uchida, E.3
Aimoto, T.4
-
27
-
-
67650609666
-
Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor beta1-associated osteoblastic changes
-
Izumi K, Mizokami A, Li YQ et al. Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor beta1-associated osteoblastic changes. Prostate 2009;69:1222-34.
-
(2009)
Prostate
, vol.69
, pp. 1222-1234
-
-
Izumi, K.1
Mizokami, A.2
Li, Y.Q.3
-
28
-
-
77949372619
-
Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer
-
Subramaniam V, Chakrabarti R, Prud'homme GJ, Jothy S. Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer. Anticancer Drugs 2010;21:351-61.
-
(2010)
Anticancer Drugs
, vol.21
, pp. 351-361
-
-
Subramaniam, V.1
Chakrabarti, R.2
Prud'homme, G.J.3
Jothy, S.4
-
29
-
-
0036924727
-
Tranilast inhibits the proliferation of uterine leiomyoma cells in vitro through G1 arrest associated with the induction of p21(waf1) and p53
-
Shime H, Kariya M, Orii A et al. Tranilast inhibits the proliferation of uterine leiomyoma cells in vitro through G1 arrest associated with the induction of p21(waf1) and p53. J Clin Endocrinol Metab 2002;87:5610-7.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5610-5617
-
-
Shime, H.1
Kariya, M.2
Orii, A.3
-
30
-
-
0035400114
-
N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-beta relesase and reduces migration and invasiveness of human malignant glioma cells
-
Platten M, Wild-Bode C, Wick W, Leitlein J, Dichgans J, Weller M. N-[3, 4-dimethoxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-beta relesase and reduces migration and invasiveness of human malignant glioma cells. Int J Cancer 2001;93:53-61.
-
(2001)
Int J Cancer
, vol.93
, pp. 53-61
-
-
Platten, M.1
Wild-Bode, C.2
Wick, W.3
Leitlein, J.4
Dichgans, J.5
Weller, M.6
-
31
-
-
84878114531
-
Stromal cells in tumor microenvironment and breast cancer
-
Mao Y, Keller ET, Garfield DH, Shen K, Wang J. Stromal cells in tumor microenvironment and breast cancer. Cancer Metastasis Rev 2013;32:303-15.
-
(2013)
Cancer Metastasis Rev
, vol.32
, pp. 303-315
-
-
Mao, Y.1
Keller, E.T.2
Garfield, D.H.3
Shen, K.4
Wang, J.5
-
32
-
-
78649638459
-
T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets
-
Barnas JL, Simpson-Abelson MR, Yokota SJ, Kelleher RJ, Bankert RB. T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets. Cancer Microenviron 2010;3:29-47.
-
(2010)
Cancer Microenviron
, vol.3
, pp. 29-47
-
-
Barnas, J.L.1
Simpson-Abelson, M.R.2
Yokota, S.J.3
Kelleher, R.J.4
Bankert, R.B.5
-
33
-
-
84865687576
-
Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders
-
Rogosnitzky M, Danks R, Kardash E. Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders. Anticancer Res 2012;32:2471-8.
-
(2012)
Anticancer Res
, vol.32
, pp. 2471-2478
-
-
Rogosnitzky, M.1
Danks, R.2
Kardash, E.3
-
34
-
-
67650305810
-
Tranilast inhibits the growth and metastasis of mammary carcinoma
-
Chakrabarti R, Subramaniam V, Abdalla S, Jothy S, Prud'homme GJ. Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 2009;20:334-45.
-
(2009)
Anticancer Drugs
, vol.20
, pp. 334-345
-
-
Chakrabarti, R.1
Subramaniam, V.2
Abdalla, S.3
Jothy, S.4
Prud'homme, G.J.5
-
35
-
-
0028341154
-
Prominent inhibitory effects of tranilast on migration and proliferation of and collagen synthesis by vascular smooth muscle cells
-
Tanaka K, Honda M, Kuramochi T, Morioka S. Prominent inhibitory effects of tranilast on migration and proliferation of and collagen synthesis by vascular smooth muscle cells. Atherosclerosis 1994;107:179-85.
-
(1994)
Atherosclerosis
, vol.107
, pp. 179-185
-
-
Tanaka, K.1
Honda, M.2
Kuramochi, T.3
Morioka, S.4
-
36
-
-
38049181485
-
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
-
Pan PY, Wang GX, Yin B et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood 2008;111:219-28.
-
(2008)
Blood
, vol.111
, pp. 219-228
-
-
Pan, P.Y.1
Wang, G.X.2
Yin, B.3
-
37
-
-
37349100945
-
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
-
Yang L, Huang J, Ren X et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 2008;13:23-35.
-
(2008)
Cancer Cell
, vol.13
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
-
38
-
-
34249300128
-
Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
-
Sinha P, Clements VK, Fulton AM, Ostrand-Rosenberg S. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res 2007;67:4507-13.
-
(2007)
Cancer Res
, vol.67
, pp. 4507-4513
-
-
Sinha, P.1
Clements, V.K.2
Fulton, A.M.3
Ostrand-Rosenberg, S.4
-
39
-
-
37049006066
-
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma
-
Melani C, Sangaletti S, Barazzetta FM, Werb Z, Colombo MP. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma. Cancer Res 2007;67:11438-46.
-
(2007)
Cancer Res
, vol.67
, pp. 11438-11446
-
-
Melani, C.1
Sangaletti, S.2
Barazzetta, F.M.3
Werb, Z.4
Colombo, M.P.5
-
40
-
-
84875598583
-
Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma
-
Kinoshita T, Ishii G, Hiraoka N et al. Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma. Cancer Sci 2013;104:409-15.
-
(2013)
Cancer Sci
, vol.104
, pp. 409-415
-
-
Kinoshita, T.1
Ishii, G.2
Hiraoka, N.3
-
41
-
-
0344010953
-
Tranilast (N-3,4-dimethoxycinamoyl anthranilic acid): a novel inhibitor of invasion-stimulating interaction between gastric cancer cells and orthotopic fibroblasts
-
Yashiro M, Murahashi K, Matsuoka T et al. Tranilast (N-3, 4-dimethoxycinamoyl anthranilic acid): a novel inhibitor of invasion-stimulating interaction between gastric cancer cells and orthotopic fibroblasts. Anticancer Res 2003;23:3899-904.
-
(2003)
Anticancer Res
, vol.23
, pp. 3899-3904
-
-
Yashiro, M.1
Murahashi, K.2
Matsuoka, T.3
-
42
-
-
84879674829
-
Inhibition of transforming growth factor-β release from tumor cells reduces their motility associated with epithelial-mesenchymal transition
-
Ohshio Y, Teramoto K, Hashimoto M, Kitamura S, Hanaoka J, Kontani K. Inhibition of transforming growth factor-β release from tumor cells reduces their motility associated with epithelial-mesenchymal transition. Oncol Rep 2013;30:1000-6.
-
(2013)
Oncol Rep
, vol.30
, pp. 1000-1006
-
-
Ohshio, Y.1
Teramoto, K.2
Hashimoto, M.3
Kitamura, S.4
Hanaoka, J.5
Kontani, K.6
|