Tranilast inhibits cell proliferation and collagen synthesis by rabbit corneal and Tenon's capsule fibroblasts

Current Eye Research

Volumn 20, Issue 4, 2000, Pages 283-286

  Oshima, Takeshi ^a,c   Kurosaka, Daijiro ^a   Kato, Katsuhiko ^a   Kurosaka, Hiroyo ^a   Mashima, Yukihiko ^a   Tanaka, Yasuhiko ^a   Tajima, Singo ^b  

^a KEIO UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c NONE   (Japan)

Author keywords

Collagen synthesis; Corneal stromal fibroblasts; Tenon's capsule fibroblasts; Tranilast; Wound healing

Indexed keywords

TRANILAST;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FIBROBLAST; GLAUCOMA; KERATECTOMY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCAR FORMATION;

EID: 0033934320     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/0271-3683(200004)2041-5FT283     Document Type: Article

References (20)

1. Skuta GL, Parrish RK2d. Wound healing in glaucoma filtering surgery. Surv Ophthalmol. 1987;32:149-170.
2. Schäffer MR, Tantry U, Ahrendt GM, Wasserkrug HL, Barbul A Stimulation of fibroblast proliferation and matrix contraction by wound fluid. Int J Biochem Cell Biol. 1997; 29:231-239.
3. Suzawa H, Kikuchi S, Ichikawa K. Koda A. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages. Jpn J Pharmacol. 1992; 60:85-90.
4. Suzawa H, Kikuchi S, Arai N, Koda A. The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keroid fibroblasts. Jpn J Pharmacol. 1992; 60:91-96.
5. Isaji M, Aruga N, Naito J, Miyata H. Inhibition by tranilast of collagen accumulation in hypersensitive granulomatous inflammation in vivo and of morphological changes and functions of fibroblasts in vitro. Life Sci. 1994;55:PL287-PL292.
6. Costa VP, Spaeth GL, Eifermam RA, Orego-Nania S. Wound healing modulation in glaucoma filtration surgery. Ophthalmic Surg. 1993;24:152-170.
7. Ellis DG, Cheng Q, Lee DA. The effects of growth factors on Tenon's capsule fibroblasts in serum-free culture. Curr Eye Res. 1996;15:27-35.
8. Yamada H, Tajima S, Nishikawa T, Murad S, Pinnell SR. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem. 1994;116:892-897.
9. Fukuyama J, Miyazawa K, Hamano S, Ujiie A. Inhibitory effects of tranilast on proliferation, migration, and collagen synthesis of human vascular smooth muscle cells. Can J Physiol Pharmacol. 1996;74:80-84.
10. Okamoto S. Effect of tranilast on corneal haze after photorefractive keratectomy (in Japanese). Atarashii Ganka (Journal of the Eye). 1997;14:239-243.
11. Sakai T, Okamoto S, Iwaki Y. The effect of tranilast on subepithelial corneal opacity after excimer laser keratectomy (in Japanese). J Jpn Ophthalmol Soc. 1997; 101:783-787.
12. Furukawa H, Nakayasu K, Gotoh T, Watanabe Y, Takano T, IshikawaT, Kanai A. Effect of topical tranilast and corticosteroids on subepithelial haze after photorefractive keratectomy in rabbits. J Refract Surg. 1997;13:S457-S458.
13. Peterkofsky B, Diegelmann R. Use of a mixture of proteinase-free collagenases for the specific assay of radio-active collagen in the presence of other proteins. Biochemistry. 1971;10:988-994.
14. 1 increase collagen biosynthesis via different mechanisms: coordinate regulation of proα1(I) and proα1(III) collagens. Arch Biochem Biophys. 1992;295:397-403.
15. Goto Y, Nishiyama M, Miyata H, Motoji N, Okuyama M, Kuroiwa H, Shigematsu A. Studies on the metabolic fate of tranilast ophthalmic solution: ocular distribution, absorption and excretion after a single and repeated ophthalmic instillation in guinea pig and rabbit eyes (in Japanese). Yakubutu-Doutai. 1993;8:151-164.
16. Assil KK, Quantock AJ. Wound healing in response to keratorefractive surgery. Surve Ophthalmol. 1993;38: 289-302.
17. Waseda T. Concentrations of tranilast in keloid tissues (in Japanese). Jpn J Dermatol. 1989;99:1159-1165.
18. Cunliffe IA, Rees RC, Rennie IG. The effect of TGF-beta 1 and TGF-beta 2 on the proliferation of human Tenon's capsule fibroblasts in tissue culture. Acta Ophthalmol Scand. 1996;74:31-35.
19. Tripathi RC, Li J, Chalam KV, Tripathi BJ. Expression of growth factor mRNAs by human Tenon's capsule fibroblasts. Exp Eye Res. 1996;63:339-346.
20. Jester JV, Barry-Lane PA, Petroll WM, Olsen DR, Cavanagh HD. Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF beta in the rabbit. Cornea. 1997;16:177-187.