Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension

American Journal of Hypertension

Volumn 28, Issue 2, 2015, Pages 239-247

  Kumar, Rahul ^a,d   Kohli, Samantha ^a,b   Mishra, Aastha ^a   Garg, Ritu ^a   Alam, Perwez ^a   Stobdan, Tsering ^a,d,e   Nejatizadeh, Azim ^a,d,f   Gupta, Mohit ^c   Tyagi, Sanjay ^c   Qadar Pasha, M A ^a,b  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c G B PANT HOSPITAL   (India)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Association study; blood pressure; epistasis; haplotype; hypertension; single nucleotide polymorphism

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ADRB2 PROTEIN, HUMAN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE EXPRESSION; GENE INTERACTION; GENE LOCUS; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE AGED; MULTIFACTOR DIMENSIONALITY REDUCTION; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; VASODILATATION; BLOOD PRESSURE; CASE CONTROL STUDY; EPISTASIS; GENETICS; METABOLISM;

ADULT; BLOOD PRESSURE; CASE-CONTROL STUDIES; EPISTASIS, GENETIC; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RECEPTORS, ADRENERGIC, BETA-2; VASODILATION;

EID: 84922522110     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpu130     Document Type: Article

References (38)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365:217-223.
2. Simino J, Shi G, Kume R, Schwander K, Province MA, Gu CC, Kardia S, Chakravarti A, Ehret G, Olshen RA, Turner ST, Ho LT, Zhu X, Jaquish C, Paltoo D, Cooper RS, Weder A, Curb JD, Boerwinkle E, Hunt SC, Rao DC. Five blood pressure loci identifed by an updated genome-wide linkage scan: meta-analysis of the Family Blood Pressure Program. Am J Hypertens 2011; 24:347-354.
3. Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, Haiman CA, Hartiala J, Harris TB, Hazen SL, Heckbert SR, Henderson BE, Hirschhorn JN, Keating BJ, Kritchevsky SB, Larkin E, Li M, Rudock ME, McKenzie CA, Meigs JB, Meng YA, Mosley TH, Newman AB, Newton-Cheh CH, Paltoo DN, Papanicolaou GJ, Patterson N, Post WS, Psaty BM, Qasim AN, Qu L, Rader DJ, Redline S, Reilly MP, Reiner A P, Rich SS, Rotter JI, Liu Y, Shrader P, Siscovick DS, Tang WH, Taylor HA, Tracy RP, Vasan RS, Waters KM, Wilks R, Wilson JG, Fabsitz RR, Gabriel SB, Kathiresan S, Boerwinkle E. Genome-wide association study of coronary heart disease and its risk factors in 8, 090 African Americans: the NHLBI CARe Project. PLoS Genet 2011; 7:e1001300.
4. Puppala S, Coletta DK, Schneider J, Hu SL, Farook VS, Dyer TD, Arya R, Blangero J, Duggirala R, Defronzo RA, Jenkinson CP. Genome-wide linkage screen for systolic blood pressure in the Veterans Administration Genetic Epidemiology Study (VAGES) of Mexican-Americans and con-frmation of a major susceptibility locus on chromosome 6q14.1. Hum Hered 2011; 71:1-10.
5. Williams SM, Ritchie MD, Phillips JA, III, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, Moore JH. Multilocus analysis of hypertension: a hierarchical approach. Hum Hered 2004; 57:28-38.
6. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet 1999; 22:239-247.
7. Cordell HJ. Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 2009; 10:392-404.
8. Moore JH. The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 2003; 56:73-82.
9. Olshansky B, Sabbah HN, Hauptman PJ, Colucci WS. Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy. Circulation 2008; 118:863-871.
10. Queen LR, Ji Y, Xu B, Young L, Yao K, Wyatt AW, Rowlands DJ, Siow RC, Mann GE, Ferro A. Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells. J Physiol 2006; 576:585-594.
11. Hesse C, Eisenach JH. Genetic variation in the beta(2)-adrenergic receptor: impact on intermediate cardiovascular phenotypes. Curr Pharmacogenomics Person Med 2008; 6:160-170.
12. Misono M, Maeda S, Iemitsu M, Nakata Y, Otsuki T, Sugawara J, Zempo H, Yoshizawa M, Miyaki A, Kuno S, Matsuda M, Ajisaka R. Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension. J Hypertens 2009; 27:1377-1383.
13. Zintzaras E, Kitsios G, Stefanidis I. Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis. Hypertension 2006; 48:700-710.
14. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16:1215.
15. Stephens M, Smith NJ, Donnelly P. A new statistical method for hap-lotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
16. Li Y, Sung WK, Liu JJ. Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows. Am J Hum Genet 2007; 80:705-715.
17. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, Li MD. A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet 2007; 80:1125-1137.
18. Curk T, Rot G, Zupan B. SNPsyn: detection and exploration of SNP-SNP interactions. Nucleic Acids Res 2011; 39:W444-W449.
19. Potter MA, De Jong KA. Cooperative coevolution: an architecture for evolving coadapted subcomponents. Evol Comput 2000; 8:1-29.
20. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
21. Stanzione R, Di AE, Evangelista A, Barbato D, Marchitti S, Zanda B, Pirisi A, Quarta G, Volpe M, Rubattu S. Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke. Am J Hypertens 2007; 20:657-662.
22. Heckbert SR, Hindorf LA, Edwards KL, Psaty BM, Lumley T, Siscovick DS, Tang Z, Durda J P, Kronmal RA, Tracy RP. Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. Circulation 2003; 107:2021-2024.
23. Lou Y, Liu J, Huang Y, Liu J, Wang Z, Liu Y, Li Z, Li Y, Xie Y, Wen S. A46G and C79G polymorphisms in the beta2-adrenergic receptor gene (ADRB2) and essential hypertension risk: a meta-analysis. Hypertens Res 2010; 33:1114-1123.
24. Souza-Costa DC, Belo VA, Silva PS, Metzger IF, Lanna CM, Machado MA, Tanus-Santos JE. eNOS haplotype associated with hypertension in obese children and adolescents. Int J Obes (Lond) 2011; 35:387-392.
25. Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Sikdar S, Gupta M, Javed S, Qadar Pasha MA. Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels signifcantly associate with risk of essential hypertension. Free Radic Biol Med 2008; 44:1912-1918.
26. Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, Schork NJ, O'Connor DT. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension 2007; 49:96-106.
27. Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfeld M, Farrall M. Two-dimensional genome-scan identifes novel epistatic loci for essential hypertension. Hum Mol Genet 2006; 15:1365-1374.
28. Kumar R, Nejatizadeh A, Gupta M, Markan A, Tyagi S, Jain SK, Qadar Pasha MA. The epistasis between vascular homeostasis genes is apparent in essential hypertension. Atherosclerosis 2012; 220:418-424.
29. Zhao Q, Wang L, Yang W, Chen S, Huang J, Fan Z, Li H, Lu X, Gu D. Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population. Pharmacogenet Genomics 2008; 18:459-466.
30. Kumar R, Kohli S, Alam P, Barkotoky R, Gupta M, Tyagi S, Jain SK, Qadar Pasha MA. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. PLoS One 2013; 8:e63934.
31. Castellano M, Rossi F, Giacche M, Perani C, Rivadossi F, Muiesan ML, Salvetti M, Beschi M, Rizzoni D, Agabiti-Rosei E. Beta(2)-adrenergic receptor gene polymorphism, age, and cardiovascular phenotypes. Hypertension 2003; 41:361-367.
32. Kullo IJ, Greene MT, Boerwinkle E, Chu J, Turner ST, Kardia SL. Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults. Atherosclerosis 2008; 196:905-912.
33. Kumar R, Nejatizadeh A, Arif E, Akhtar S, Gupta M, Tyagi S, Goyal AK, Jain SK, Qadar Pasha MA. Multi-locus interactions of vascular homeo-stasis genes in essential hypertension: a gender-based study. Clin Chim Acta 2009; 405:87-93.
34. Queen LR, Xu B, Horinouchi K, Fisher I, Ferro A. beta(2)-adrenocep-tors activate nitric oxide synthase in human platelets. Circ Res 2000; 87:39-44.
35. Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Tyagi S, Jain SK, Qadar Pasha MA. CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension. Clin Biochem 2010; 43:136-141.
36. Charron S, Duong C, Menard A, Roy J, Eliopoulos V, Lambert R, Deng AY. Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension 2005; 46:1300-1308.
37. Hoit BD, Suresh D P, Craf L, Walsh RA, Liggett SB. beta2-adrenergic receptor polymorphisms at amino acid 16 diferentially infuence agonist-stimulated blood pressure and peripheral blood fow in normal individuals. Am Heart J 2000; 139:537-542.
38. Nakamura Y, Koyama K, Matsushima M. VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators. J Hum Genet 1998; 43:149-152.