Combination of polymorphisms in the β2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension

Journal of Hypertension

Volumn 27, Issue 7, 2009, Pages 1377-1383

  Misono, Maiko ^a   Maeda, Seiji ^a   Iemitsu, Motoyuki ^a   Nakata, Yoshio ^a   Otsuki, Takeshi ^a   Sugawara, Jun ^b   Zempo, Hirofumi ^a   Yoshizawa, Mutsuko ^a   Miyaki, Asako ^a   Kuno, Shinya ^a   Matsuda, Mitsuo ^a   Ajisaka, Ryuichi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Combination; Hypertension; Nitric oxide synthase 3; Single nucleotide polymorphism; 2 adrenergic receptor

Indexed keywords

ARGININE; ASPARTIC ACID; BETA 2 ADRENERGIC RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTAMIC ACID; GLYCINE; NOS3 PROTEIN, HUMAN; PRIMER DNA;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR RISK; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REST; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; GENETICS; JAPAN; MIDDLE AGED; NUCLEOTIDE SEQUENCE;

AGED; AGED, 80 AND OVER; BASE SEQUENCE; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DNA PRIMERS; FEMALE; HUMANS; HYPERTENSION; JAPAN; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 67649755199     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32832b7ead     Document Type: Article

References (44)

1. Ueshima H, Zhang XH, Choudhury SR. Epidemiology of hypertension in China and Japan. J Hum Hypertens 2000; 14:765-769.
2. Singh RB, Suh IL, Singh VP, Chaithiraphan S, Laothavorn P, Sy RG, et al.Hypertension and stroke in Asia: prevalence, control and strategies in developing countries for prevention. J Hum Hypertens 2000; 14:749- 763.
3. Hernandez-Hernandez R, Armas-Padilla MC, Armas-Hernandez MJ, Velasco M. Hypertension and cardiovascular health in Venezuela and Latin American countries. J Hum Hypertens 2000; 14 (Suppl 1):S2-S5.
4. Halberstein RA. Blood pressure in the Caribbean. Hum Biol 1999; 71:659-684.
5. Gupta R. Hypertension in India: definition, prevalence and evaluation. J Indian Med Assoc 1999; 97:74-80.
6. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003; 289:2363- 2369.
7. He J, Whelton PK. Epidemiology and prevention of hypertension. Med Clin North Am 1997; 81:1077-1097.
8. Miyamoto Y, Saito Y, Kajiyama N, Yoshimura M, Shimasaki Y, Nakayama M, et al. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 1998; 32:3-8.
9. Bray MS, Krushkal J, Li L, Ferrell R, Kardia S, Sing CF, et al. Positional genomic analysis identifies the beta2-adrenergic receptor gene as a susceptibility locus for human hypertension. Circulation 2000; 101:2877- 2882.
10. Lacolley P, Gautier S, Poirier O, Pannier B, Cambien F, Benetos A. Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects. J Hypertens 1998; 16:31-35.
11. Kotanko P, Binder A, Tasker J, DeFreitas P, Kamdar S, Clark AJ, et al.Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Hypertension 1997; 30:773-776.
12. Pereira AC, Floriano MS, Mota GF, Cunha RS, Herkenhoff FL, Mill JG, et al.b2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population. Hypertension 2003; 42:685-692.
13. Ge D, Huang J, He J, Li B, Duan X, Chen R, et al. b2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese. Ann Hum Genet 2005; 69:36-44.
14. Ranade K, Shue WH, Hung YJ, Hsuing CA, Chiang FT, Pesich R, et al. The glycine allele of a glycine/arginine polymorphism in the b2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin. Am J Hypertens 2001; 14:1196-1200.
15. Mitchell GF, Guo CY, Kathiresan S, Vasan RS, Larson MG, Vita JA, et al.Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study. Hypertension 2007; 49:1285-1290.
16. Chen W, Srinivasan SR, Bond MG, Tang R, Urbina EM, Li S, et al. Nitric oxide synthase gene polymorphism (G894T) influences arterial stiffness in adults: the Bogalusa Heart Study. Am J Hypertens 2004; 17:553-559.
17. Chen W, Srinivasan SR, Li S, Boerwinkle E, Berenson GS. Gender-specific influence of NO synthase gene on blood pressure since childhood: the Bogalusa Heart Study. Hypertension 2004; 44:668-673.
18. Ferro A, Queen LR, Priest RM, Xu B, Ritter JM, Poston L, Ward JP. Activation of nitric oxide synthase by b2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol 1999; 126:1872-1880.
19. Sugawara J, Hayashi K, Yokoi T, Cortez-Cooper MY, DeVan AE, Anton MA, et al. Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens 2005; 19:401-406.
20. Yamashina A,Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002; 25:359-364.
21. Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med 1997; 157:2413-2446.
22. Kumahara H, Schutz Y, Ayabe M, Yoshioka M, Yoshitake Y, Shindo M, et al.The use of uniaxial accelerometry for the assessment of physical-activityrelated energy expenditure: a validation study against whole-body indirect calorimetry. Br J Nutr 2004; 91:235-243.
23. Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 1993; 25:71-80.
24. Ranade K, Chang MS, Ting CT, Pei D, Hsiao CF, Olivier M, et al. Highthroughput genotyping with single nucleotide polymorphisms. Genome Res 2001; 11:1262-1268.
25. Guimaraes S, Moura D. Vascular adrenoceptors: an update. Pharmacol Rev 2001; 53:319-356.
26. Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33:9414-9419.
27. Gratze G, Fortin J, Labugger R, Binder A, Kotanko P, Timmermann B, et al.b-2 adrenergic receptor variants affect resting blood pressure and agonistinduced vasodilation in young adult Caucasians. Hypertension 1999; 33:1425-1430.
28. Hoit BD, Suresh DP, Craft L, Walsh RA, Liggett SB. beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agoniststimulated blood pressure and peripheral blood flow in normal individuals. Am Heart J 2000; 139:537-542.
29. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43:109-142.
30. Huang PL, Huang Z,Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, et al.Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377:239-242.
31. Sander M, Chavoshan B, Victor RG. A large blood pressure-raising effect of nitric oxide synthase inhibition in humans. Hypertension 1999; 33:937- 942.
32. Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci U S A 2000; 6:2832-2835.
33. Jia H, Sharma P, Hopper R, Dickerson C, Lloyd DD, Brown MJ. b2- Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians. J Hypertens 2000; 18:687-693.
34. Xie HG, Stein CM, Kim RB, Gainer JV, Sofowora G, Dishy V, et al. Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin Pharmacol Ther 2000; 67:670-675.
35. Kishimoto T, Misawa Y, Kaetu A, Nagai M, Osaki Y, Okamoto M, et al.eNOS Glu298Asp polymorphism and hypertension in a cohort study in Japanese. Prev Med 2004; 39:927-931.
36. Karvonen J, Kauma H, Kervinen K, Rantala M, Ikäheimo M, Pä ivä nsalo M, et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort. J Intern Med 2002; 251:102-110.
37. Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, Boerwinkle E. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation 1999; 99:1407-1410.
38. Xu X, Rogus JJ, Terwedow HA, Yang J, Wang Z, Chen C, et al. An extremesib- pair genome scan for genes regulating blood pressure. Am J Hum Genet 1999; 64:1694-1701.
39. Sharma P, Fatibene J, Ferraro F, Jia H, Monteith S, Brown C, et al. A genome-wide search for susceptibility loci to human essential hypertension. Hypertension 2000; 35:1291-1296.
40. Rice T, Rankinen T, Chagnon YC, Province MA, Pe' russe L, Leon AS, et al.Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics. Hypertension2002; 39:1037-1043.
41. Yang M, Choi Y, Hwangbo B, Lee JS. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility. Lung Cancer 2007; 57:135-142.
42. Hizawa N, Maeda Y, Konno S, Fukui Y, Takahashi D, Nishimura M. Genetic polymorphisms at FCER1B and PAI-1 and asthma susceptibility. Clin Exp Allergy 2006; 36:872-876.
43. Ellsworth DL, Coady SA, Chen W, Srinivasan SR, Elkasabany A, Gustat J, et al. Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2002; 26:928-937.
44. Tanus-Santos JE, Desai M, Flockhart DA. Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics 2001; 11:719-725.