VNTR (variable number of tandem repeat) sequences as transcriptional, translational, or functional regulators

Journal of Human Genetics

Volumn 43, Issue 3, 1998, Pages 149-152

  Nakamura, Yusuke ^a   Koyama, Kumiko ^a   Matsushima, Mieko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Disease susceptibility; Personality traits; Transcriptional regulator; Translational regulator; VNTR (variable number of tendem repeat)

Indexed keywords

GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; PERSONALITY; PROTEIN SYNTHESIS; REGULATORY SEQUENCE; REVIEW; VARIABLE NUMBER OF TANDEM REPEAT;

GENE EXPRESSION REGULATION; HUMANS; MINISATELLITE REPEATS; PERSONALITY; PROTEIN BIOSYNTHESIS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 0031613041     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050059     Document Type: Article

References (28)

1. Asghari V, Schoots O, van Kats S, Ohara K, Jovanovic V, Guan HC, Bunzow JR, Petronis A, Van Tol HH (1994) Dopamine D4 receptor repeat: Analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 46: 364-373
2. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH (1996) Population and familial association between the D4 dopamine receptor gene and measures of novel seeking. Nature Genet 12: 81-84
3. Bennett ST, Wilson AJ, Esposito L, Bouzekri N, Undelien DE, Cucca F, Nistico L, Buzzetti R, the IMDIAB group, Bosi E, Pociot F, Nerup J, Cambon-Thomsen A, Pugliese A, Shield JPH, McKinney PA, Bain SC, Polychronakos C, Todd JA (1997) Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untranslated paternal allele. Nature Genet 17: 350-353
4. Chinen K, Takahashi E, Nakamura Y (1996) Isolation and mapping of a human gene (SEC14L). partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3′ untranslated region. Cytogenet Cell Genet 73: 218-223
5. Ebstein RP, Novik O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH (1996) Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novel seeking. Nature Genet 12: 78-80
6. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624
7. Kasai K, Nakamura Y, White R (1990) Amplification of a VNTR locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J Forensic Sci 35: 1196-1200
8. Krontiris TG, Devlin B, Karp DD, Robert NJ, Risch N (1993) An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med 329: 517-523
9. Lafreniere RG, Rochefort DL, Chretien N, Rommens JM, Cochius JI, Kalviainen R, Nousiainen U, Patry G, Farrell K, Soderfeldt B, Federico A, Hale BR, Cossio OH, Sorensen T, Pouliot MA, Kmiec T, Uldall P, Janszky J, Pranzatelli MR, Andermann F, Andermann E, Rouleau GA (1997) Unstable insertion in the 5′ flanking region of the cystatin B gene is the most common mutation in progressive myoclonus epilepsy type 1, EPM1. Nature Genet 15: 298-302
10. Lalioti MD, Scott HS, Buresi C, Rossier C, Bottani A, Morris MA, Malafosse A, Antonarakis SE (1997) Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy. Nature 386: 847-850
11. Lancaster CA, Peat N, Duhig T, Wilson D, Taylor-Papadimitriou J, Gendler SJ (1990) Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit. Biochem Biophys Res Com 173: 1019-1029
12. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531
13. Lichter JB, Barr CL, Kennedy JL, Van Tol HHM, Kidd KK, Livak KJ (1993) A hypervariable segment in the human dopamine receptor D4 (D4DR) gene. Hum Mol Genet 2: 767-773
14. Lucassen AM, Julier C, Beressi J-P, Boitard C, Froguel P, Lathrop M, Bell JI (1993) Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nature Genet 4: 305-310
15. Meloni R, Albanese V, Ravassard P, Treihou F, Mallet J (1998) A tetranucleotide polymorphic microsatellite, located in the first intron of the tyrosine hydroxylase gene, acts as a transcription regulatory element in vitro. Hum Molec Genet 7: 423-428
16. Nakamura Y, Leppert M, O'Connell P, Wolff R, Holm T, Culver M, Martin C, Fujimoto E, Hoff M, Kumlin E, White R (1987) Variable Number of Tandem Repeat (VNTR) markers for human gene mapping. Science 235: 1616-1622
17. Nakamura Y, Carlson M, Krapcho K, Kanamori M, White R (1988) A new approach for isolating VNTR markers. Am J Hum Genet 43: 854-859
18. Odelberg SJ, Plaetke R, Eldridge JR, Ballard L, O'Connell P, Nakamura Y, Leppert M, Lalouel J-M, White R (1989) Characterization of VNTR loci by high-resolution agarose gel electrophoresis: Implications for parentage testing and forensic individualization Genomics 5: 915-924
19. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD (1996) Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347: 731-733
20. Phelan CM, Rebbeck TR, Weber BL, Devilee P, Ruttledge MH, Lynch HT, Lenoir GM, Stratton MR, Easton DF, Ponder BAJ, Cannon-Albright L, Larsson C, Goldgar DE, Narod SA (1996) Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nature Genet 12: 309-314
21. Pugliese A, Zeller M, Fernandez A, Zalcberg LJ, Bartlett RJ, Ricordi C, Pietropaolo M, Eisenbarth GS, Bennett ST, Patel DD (1997) The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes Nature Genet 15: 293-296
22. Rubinstein, M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougall JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, Grandy DK (1997) Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90: 991-1001
23. Trepicchio WL, Krontiris TG (1992) Members of the rel/NF-χB family of transcriptional regulatory proteins bind the HRAS minisatellite DNA sequence. Nucl Acids Res 20: 2427-2434
24. Trepicchio WL, Krontiris TG (1993) IGH minisatellite suppression of USF-binding-site- and Eμ-mediated transcriptional activation of the adenovirus major late promoter. Nucl Acids Res 21: 977-985
25. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C (1997) Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM locus. Nature Genet 15: 289-296
26. Van Tol HHM, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O, Kennedy J, Seaman P, Niznik HB, Jovanovic V (1992) Multiple dopamine D4 receptor variants in the human population. Nature 358: 149-152
27. Wiseman SA, Powell JT, Humphries SE, Press M (1993) The magnitude of the hypercholesterolemia of hypothyroidism is associated with variation in the low density lipoprotein receptor gene. J Clin Endocrinol Metab 77: 108-112
28. Zhao H, Zhang H, Rotter JI (1997) Cost-effective sib-pair designs in the mapping of quantitative trait loci. Am J Hum Genet 60: 1211-1221