Five blood pressure loci identified by an updated genome-wide linkage scan: Meta-analysis of the family blood pressure program

American Journal of Hypertension

Volumn 24, Issue 3, 2011, Pages 347-354

  Simino, Jeannette ^a   Shi, Gang ^a   Kume, Rezart ^a   Schwander, Karen ^a   Province, Michael A ^a   Gu, C Charles ^a   Kardia, Sharon ^b   Chakravarti, Aravinda ^c   Ehret, Georg ^c,d   Olshen, Richard A ^e   Turner, Stephen T ^f   Ho, Low Tone ^g   Zhu, Xiaofeng ^h   Jaquish, Cashell ⁱ   Paltoo, Dina ⁱ   Cooper, Richard S ^j   Weder, Alan ^k   Curb, J David ^l   Boerwinkle, Eric ^m   Hunt, Steven C ⁿ   Rao, Dabeeru C ^a   more..

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e STANFORD UNIVERSITY   (United States)

^f MAYO CLINIC   (United States)

^g TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^h CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^j LOYOLA UNIVERSITY CHICAGO   (United States)

^k UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^l UNIVERSITY OF HAWAII   (United States)

^m UNIVERSITY OF TEXAS   (United States)

ⁿ UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

more..

Author keywords

blood pressure; genetics; hypertension; linkage; meta analysis; QTL

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ADULT; AFRICAN AMERICAN; ARTICLE; BLOOD PRESSURE; CAUCASIAN; CHROMOSOME 20Q; CHROMOSOME 21Q; CHROMOSOME 6P; CHROMOSOME 8Q; ETHNIC DIFFERENCE; FAMILY; FEMALE; FISHER EXACT TEST; GENE LOCATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; HISPANIC; HUMAN; MALE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SCORING SYSTEM;

EID: 79951681492     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2010.238     Document Type: Article

References (39)

1. Ostchega Y, Yoon SS, Hughes J, Louis T. Hypertension awareness, treatment, and control-continued disparities in adults: United States, 2005-2006. NCHS Data Brief 2008:1-8.
2. Multi-center genetic study of hypertension: the Family Blood Pressure Program (FBPP). Hypertension 2002;39:3-9.
3. Boerwinkle E; Family Blood Pressure Program. All for one and one for all: introduction to a coordinated analysis of the Gly-460-Trp α-adducin polymorphism. Am J Hypertens 2000; 13:734-735. (Pubitemid 30459888)
4. Bielinski SJ, Lynch AI, Miller MB, Weder A, Cooper R, Oberman A, Chen YD, Turner ST, Fornage M, Province M, Arnett DK. Genome-wide linkage analysis for loci affecting pulse pressure: the Family Blood Pressure Program. Hypertension 2005; 46:1286-1293. (Pubitemid 43189725)
5. Province MA, Kardia SL, Ranade K, Rao DC, Thiel BA, Cooper RS, Risch N, Turner ST, Cox DR, Hunt SC, Weder AB, Boerwinkle E; National Heart, Lung and Blood Institute Family Blood Pressure Program. A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program. Am J Hypertens 2003; 16:144-147. (Pubitemid 36143434)
6. Wu X, Kan D, Province M, Quertermous T, Rao DC, Chang C, Mosley TH, Curb D, Boerwinkle E, Cooper RS. An updated meta-analysis of genome scans for hypertension and blood pressure in the NHLBI Family Blood Pressure Program (FBPP). Am J Hypertens 2006; 19:122-127. (Pubitemid 43217046)
7. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009; 461:747-753.
8. Marshfield Clinic mammalian genotyping service. . http://research. marshfieldclinic.org/genetics/GeneticResearch/screeningsets.asp
9. Cui JS, Hopper JL, Harrap SB. Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension 2003; 41:207-210. (Pubitemid 36204890)
10. Tobin MD, Sheehan NA, Scurrah KJ, Burton PR. Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med 2005; 24:2911-2935. (Pubitemid 41419179)
11. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30:97-101.
12. Province MA. The significance of not finding a gene. Am J Hum Genet 2001; 69:660-663.
13. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM. Genome-wide association study of blood pressure and hypertension. Nat Genet 2009; 41:677-687.
14. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight B F, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan D P, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009; 41:666-676.
15. Topol EJ, Frazer KA. The resequencing imperative. Nat Genet 2007; 39:439-440. (Pubitemid 46514758)
16. Ciullo M, Bellenguez C, Colonna V, Nutile T, Calabria A, Pacente R, Iovino G, Trimarco B, Bourgain C, Persico MG. New susceptibility locus for hypertension on chromosome 8q by efficient pedigree-breaking in an Italian isolate. Hum Mol Genet 2006; 15:1735-1743. (Pubitemid 43904839)
17. Gu CC, Hunt SC, Kardia S, Turner ST, Chakravarti A, Schork N, Olshen R, Curb D, Jaquish C, Boerwinkle E, Rao DC. An investigation of genome-wide associations of hypertension with microsatellite markers in the Family Blood Pressure Program (FBPP). Hum Genet 2007; 121:577-590. (Pubitemid 46706069)
18. Adeyemo A, Gerry N, Chen G, Herbert A, Doumatey A, Huang H, Zhou J, Lashley K, Chen Y, Christman M, Rotimi C. A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 2009; 5:e1000564.
19. Adeyemo A, Luke A, Wu X, Cooper RS, Kan D, Omotade O, Zhu X. Genetic effects on blood pressure localized to chromosomes 6 and 7. J Hypertens 2005; 23: 1367-1373. (Pubitemid 40933957)
20. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D. The human genome browser at UCSC. Genome Res 2002; 12:996-1006. (Pubitemid 34662293)
21. Nadar SK, Blann AD, Lip GY. Plasma and platelet-derived vascular endothelial growth factor and angiopoietin-1 in hypertension: effects of antihypertensive therapy. J Intern Med 2004; 256:331-337. (Pubitemid 39304345)
22. Pankow JS, Rose KM, Oberman A, Hunt SC, Atwood LD, Djoussé L, Province MA, Rao DC. Possible locus on chromosome 18q influencing postural systolic blood pressure changes. Hypertension 2000; 36:471-476.
23. Broeckel U, Hengstenberg C, Mayer B, Holmer S, Martin LJ, Comuzzie AG, Blangero J, Nürnberg P, Reis A, Riegger GA, Jacob HJ, Schunkert H. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 2002; 30:210-214.
24. Vidan-Jeras B, Gregoric A, Jurca B, Jeras M, Bohinjec M. Possible influence of genes located on chromosome 6 within or near to the major histocompatibility complex on development of essential hypertension. Pflugers Arch 2000; 439: R60-R62.
25. Pausova Z, Deslauriers B, Gaudet D, Tremblay J, Kotchen TA, Larochelle P, Cowley AW, Hamet P. Role of tumor necrosis factor-α gene locus in obesity and obesity-associated hypertension in French Canadians. Hypertension 2000; 36:14-19. (Pubitemid 30602146)
26. Rutherford S, Cai G, Lopez-Alvarenga JC, Kent JW, Voruganti VS, Proffitt JM, Curran JE, Johnson M P, Dyer TD, Jowett JB, Bastarrachea RA, Atwood LD, Goring HH, Maccluer JW, Moses EK, Blangero J, Comuzzie AG, Cole SA. A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study. Am J Hum Genet 2007; 81:744-755. (Pubitemid 47596542)
27. Xu X, Rogus JJ, Terwedow HA, Yang J, Wang Z, Chen C, Niu T, Wang B, Xu H, Weiss S, Schork NJ, Fang Z. An extreme-sib-pair genome scan for genes regulating blood pressure. Am J Hum Genet 1999; 64:1694-1701. (Pubitemid 30481522)
28. Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosley T, Gu CC, Tang H, Rao DC, Risch N, Weder A. Admixture mapping for hypertension loci with genome-scan markers. Nat Genet 2005; 37:177-181.
29. Zhu X, Cooper RS. Admixture mapping provides evidence of association of the VNN1 gene with hypertension. PLoS ONE 2007; 2:e1244.
30. Ding K, Feng D, de Andrade M, Mosley TH Jr, Turner ST, Boerwinkle E, Kullo IJ. Genomic regions that influence plasma levels of inflammatory markers in hypertensive sibships. J Hum Hypertens 2008; 22:102-110.
31. Wilhelmsen L, Svärdsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med 1984; 311:501-505. (Pubitemid 14059351)
32. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342:836-843. (Pubitemid 30165206)
33. Jacobs KB, Gray-McGuire C, Cartier KC, Elston RC. Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure. BMC Genet 2003; 4 Suppl 1:S82.
34. Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, Boerwinkle E. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation 1999; 99:1407-1410. (Pubitemid 29140903)
35. Barbalic M, Narancic NS, Skaric-Juric T, Salihovic M P, Klaric IM, Lauc LB, Janicijevic B, Farrall M, Rudan I, Campbell H, Wright AF, Hastie ND, Rudan P. A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate. Am J Hypertens 2009; 22:663-668.
36. Iwai N, Katsuya T, Ishikawa K, Mannami T, Ogata J, Higaki J, Ogihara T, Tanabe T, Baba S. Human prostacyclin synthase gene and hypertension: the Suita Study. Circulation 1999; 100:2231-2236.
37. Hunt SC, Ellison RC, Atwood LD, Pankow JS, Province MA, Leppert MF. Genome scans for blood pressure and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension 2002; 40:1-6. (Pubitemid 34755970)
38. Kardia SL, Rozek LS, Krushkal J, Ferrell RE, Turner ST, Hutchinson R, Brown A, Sing C F, Boerwinkle E. Genome-wide linkage analyses for hypertension genes in two ethnically and geographically diverse populations. Am J Hypertens 2003; 16:154-157. (Pubitemid 36143437)
39. Rao DC, Province MA, Leppert M F, Oberman A, Heiss G, Ellison RC, Arnett DK, Eckfeldt JH, Schwander K, Mockrin SC, Hunt SC; HyperGEN Network. A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network. Am J Hypertens 2003; 16:148-150. (Pubitemid 36143435)