Abnormal functional connectivity of the amygdala-based network in resting-state fMRI in adolescents with generalized anxiety disorder

Medical Science Monitor

Volumn 21, Issue , 2015, Pages 459-467

  Liu, Wen Jing ^a   Yin, Da Zhi ^b   Cheng, Wen Hong ^a   Fan, Ming Xia ^b   You, Mei Na ^a   Men, Wei Wei ^b   Zang, Li Li ^b   Shi, Dian Hong ^a   Zhang, Fang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Adolescent; Amygdala; Anxiety disorders

Indexed keywords

ADOLESCENT; ADOLESCENT BEHAVIOR; ADULT; AMYGDALOID NUCLEUS; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CONNECTOME; CONTROLLED STUDY; DISEASE SEVERITY; DSM-IV; EMOTIONAL DISORDER; FEMALE; FUNCTIONAL CONNECTIVITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENERALIZED ANXIETY DISORDER; HUMAN; INSULA; MALE; PREFRONTAL CORTEX; PUTAMEN; RESTING STATE NETWORK; SELF-RATING ANXIETY SCALE; SUPERIOR TEMPORAL GYRUS; ABNORMALITIES; AMYGDALA; ANXIETY DISORDER; CHINA; EMOTION; NERVE CELL NETWORK; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHYSIOLOGY; QUESTIONNAIRE;

ADOLESCENT; AMYGDALA; ANXIETY DISORDERS; CHINA; EMOTIONS; HUMANS; MAGNETIC RESONANCE IMAGING; NERVE NET; PREFRONTAL CORTEX; SURVEYS AND QUESTIONNAIRES;

EID: 84922521943     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.893373     Document Type: Article

References (51)

1. Costello EJ, Egger HL, Angold A: The developmental epidemiology of anxiety disorders: phenomenology,prevalence, and comorbidity. Child Adolesc Psychiatr Clin N Am, 2005; 14(4): 631–48
2. Beesdo K, Pine DS, Lieb R, Wittchen HU: Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Arch Gen Psychiatry, 2010; 67(1): 47–57
3. Jacobson CM, Muehlenkamp JJ, Miller AL, Turner JB: Psychiatric impairment among adolescents engaging in different types of deliberate self-harm. J Clin Child Adolesc Psychol, 2008; 37(2): 363–75
4. Foley DL, Goldston DB, Costello EJ, Angold A: Proxiamal psychiatric risk factors for suicidality in youth: the Great Smoky Moutains Study. Arch Gen Psychiatry, 2006; 63(9): 1017–24
5. Asbahr FR: Anxiety disorders in childhood and adolescence: clinical and neurobiological aspects. J Pediatr, 2004; 80(2 Suppl.): 28–34
6. Birmaher B, Yelovich AK, Renaud J: Pharmacologic treatment for children and adolescents with anxiety disorders. Pediatr Clin North Ann, 1998; 45: 1187–204
7. Chavira DA, Stein MB, Bailey K, Stein MT: Child anxiety in primary care: prevalent but untreated. Depress Anxiety, 2004; 20(4): 155–64
8. Etkin A, Wager T: Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Procesing in PTSD, Social Anxiety Disorder, and Specific Phobia. Am J Psychiatry, 2007; 164(10): 1476–88
9. Cannistraro PA, Rauch SL: Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies. Psychopharmacol Bull, 2003; 37(4): 8–25
10. Strawn JR, Adler CM, Chu W et al: Adolescent generalized anxiety disorder: neurophysiology and neurochemistry. Annual Meeting of the American Academy of Child and Adolescent Psychiatry(AACAP), New York, NY, 2010 October; 26–31
11. Behar E, DiMarco ID, Hekler EB et al: Current theoretical models of generalized anxiety disorder (GAD): Conceptual review and treatment implications. J Anxiety Disord, 2009; 23: 1011–23
12. Strawn JR, Wehry AM, DelBello MP et al: Establishing the neurobiologic basis of treatment in children and adolescents with generalized anxiety disorder. Depress Anxiety, 2012; 29: 328–39
13. Strawn JR, Bitter SM, Weber WA et al: Neurocircuitry of generalized anxiety disorder in adolescents: a pilot functional neuroimaging and functional connectivity study. Depress Anxiety, 2012; 29: 939–47
14. Mc Clure EB, Monk CS, Nelson EE et al: Abormal attention Modulation of fear circuit functiona in pediatric generalized anxiety disorder. Arch Gen Psychiatry, 2007; 64: 97–106
15. Etkin A, Katherine E, Alan FS et al: Disrupted Amygdala Subregein Functional Connectivity in Generalized Anxiety Disorder. Arch Gen Psychiatry, 2009; 66(12): 1361–72
16. Roy AK, Fudge JL, Kelly C et al: Intrinsic Functional Connectivity of Amygdala- Based Networks in Adolescent Generalized Anxiety Disorder. J Am Acad Child Adolesc Psychiatry, 2013; 2(3): 290–99.e2
17. Hoehn-Saric R, Schlund MW, Wong SH: Effects of citalopram on worry and brain activation in patients with generalized anxiety disorder. Psychiatry Res, 2004; 131(1): 11–21
18. American Psychiatric Association. Diagnostic and Statistical Manual of MentalDisorders. 4th ed. Washington, DC: American Psychiatric Association; 1994
19. Wang K, Su LY, Zhu Z et al: Norms of the Screen for Child Anxiety Related Emotional Disorders in Chinese Urban Children. Chinese Journal of Clinical Psychology, 2002; 10(4): 270–72
20. Busner J, Targum SD: The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont), 2007; 4(7): 28–37
21. Liu YX, Liu J, Wang YF: Reliability and validity of Chinese version of the Mini International Neuropsychiatric Interview for Children and Adolescents (Child Version). Chinese Mental Health Journal, 2001; 25(1): 8–13
22. Chao Gan Y, Yu Feng Z: DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI. Front Syst Neurosci, 2001; 4(13): 1–7
23. Song XW, Zhang YD, Xiang YL et al: Rest: a toolkit for resting-state functional magnetic resonance imaging data processing. PloS One, 2011; 6(9): e25031
24. Hampson M, Peterson BS, Skudlarski P et al: Detection of functional connectivity using temporal correlations in MR images. Hum Brain Mapp, 2002; 15(4): 247–62
25. Prater KE, Hosanagar A, Klumpp H et al: Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depress Anxiety, 2013; 30(3): 234–41
26. Balconi M: Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques. Neurosci Bull, 2013; 29(3): 381–89
27. Yiniu W, Yuejia L: Emotional Disorders in Patients with Prefrontal Cortex Lesions, 2004; 12(2): 161–67
28. Fitzgerald KD, Liu Y, Stern ER et al: Reduced error-related activation of dorsolateral prefrontal cortex across pediatric anxiety disorders. J Am Acad Child Adolesc Psychiatry, 2013; 52(11): 1183–91
29. Ball TM, Ramsawh HJ, Campbell-Sills L et al: Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders. Psychol Med, 2013; 43(7): 1475–86
30. Mathew SJ, Mao X, Coplan JD et al: Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study. Am J Psychiatry, 2004; 161(6): 1119–21
31. Behar E, DiMarco ID, Hekler EB et al: Current theoretical models of generalized anxiety disorder (GAD): conceptual review and treatment implications. J Anxiety Disord, 2009; 23(8): 1011–23
32. Pfeifer JH, Blakemore SJ: Adolescent social cognitive and affective neuroscience: past, prescent, and future. Soc Cogn Affect Neurosci, 2012; 7(1): 1–10
33. McClure EB, Monk CS, Nelson EE et al: Abormal attention Modulation of fear circuit functiona in pediatric generalized anxiety disorder. Arch Gen Psychiatry, 2007; 64: 97–106
34. Baur V, Hänggi J, Langer N et al: Resting-state functional and structural connectivity within an insula-amygdala route specifically index state and trait anxiety. Biol Psychiatry, 2013; 73(1): 85–92
35. Nieuwenhuys R: The insular cortex: a review. Prog Brain Res, 2012; 195: 123–63
36. Paulus MP, Stein MB: Interoception in anxiety and depression. Brain Struct Funct, 2010; 214: 451–63
37. LeDoux J: The emotional brain, fear, and the amygdala. Cell Mol Neurobiol, 2003; 23(45): 727–38
38. Seymour B, Daw N, Dayan P et al: Differential encoding of losses and gains in the human striatum. J Neurosci, 2007; 27(18): 4826–31
39. Pohlack ST, Nees F, Ruttorf M, Jäncke L: Activation of the ventral striatum during aversive contextual conditioning in humans. Biological Psychology, 2012; 91: 74–80
40. Guyer AE, Choate VR, Detloff A et al: Striatal functional alteration during incentive anticipation in pediatric anxiety disorders. Am J Psychiatry, 2012; 169(2): 205–12
41. Yang H, Spence JS, Devous MD Sr et al: Striatal-limbic activation is associated with intensity of anticipatory anxiety. Psychiatry Res, 2012; 204(2– 3): 123–31
42. Liao W, Qiu CJ, Gentill C et al: Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state fMRI study. Plos One, 2010; 5(12): e15238
43. Miyahara M, Harada T, Ruffman T et al: Functional connectivity between amygdala and facial regions involved in recognitionof facial threat. Soc Cogn Affect Neurosci, 2013; 8(2): 181–89
44. De Bellis MD, Keshavan MS, Shifflett H et al: Superior temporal gyrus volumes in pediatric generalized anxiety disorder. Biol Psychiatry, 2012; 51(7): 553–62
45. Supple WF, Leaton RN, Fanselow MS: Effects of cerebellar vermal lesions on species-specific fear responses,neophobia, and taste-aversion learning in rats. Psysiol Behav, 1987; 39: 579–86
46. Sacchetti B, Scelfo B, Strata P: The cerebellum: synaptic changes and fear conditioning. Neuroscientist, 2005; 11(3): 217–27
47. Sacchetti B, Sacco T, Strata P: Reversible inactivation of amygdala and cerebellum but not perirhinal cortex impairs reactivated fear memories. Eur J Neurosci, 2007; 25(9): 2875–84
48. Schmahmann JD, Caplan D: Cognition, emotion and the cerebellum. Brain, 2006; 129: 290–92
49. Stoodley CJ: The cerebellum and cognition: evidence from functional imaging studies. Cerebellum, 2012; 11(2): 352–65
50. De Smet HJ, Paquier P, Verhoeven J, Mariën P: The cerebellum: Its role in language and related cognitive and affective functions. Brain Lang, 2013; 127(3): 334–42
51. Schutter DJ, Enter D, Hoppenbrouwers SS: High-frequency repetitive transcranial magnetic stimulation to the cerebellum and implicit processing of happy facial expressions. J Psychiatry Neurosci, 2009; 34(1): 60–65