Vitamin D deficiency in the ICU: A systematic review

Minerva Endocrinologica

Volumn 39, Issue 4, 2014, Pages 275-287

  Zajic, P ^a   Amrein, K ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Critical care; Critical illness; Health care; Intensive care units; Outcome assessment; Prevalence; Vitamin D

Indexed keywords

CELL NUCLEUS RECEPTOR; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; VITAMIN D;

ADVERSE OUTCOME; CRITICAL ILLNESS; HEALTH CARE; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MORTALITY; OUTCOME ASSESSMENT; REVIEW; SEPSIS; SYSTEMATIC REVIEW; VITAMIN D DEFICIENCY; VULNERABLE POPULATION; AGE; ARTIFACT; BLOOD; CLINICAL TRIAL (TOPIC); COHORT ANALYSIS; DOUBLE BLIND PROCEDURE; ELECTROLYTE BALANCE; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; INTERVENTION STUDY; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); OBSERVATIONAL STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PROGNOSIS; TREATMENT OUTCOME;

AGE FACTORS; ARTIFACTS; CLINICAL TRIALS AS TOPIC; COHORT STUDIES; CRITICAL ILLNESS; DOUBLE-BLIND METHOD; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM; INTENSIVE CARE; INTENSIVE CARE UNITS; INTERVENTION STUDIES; META-ANALYSIS AS TOPIC; MULTICENTER STUDIES AS TOPIC; OBSERVATIONAL STUDY AS TOPIC; PROGNOSIS; RECEPTORS, CALCITRIOL; TREATMENT OUTCOME; VITAMIN D; VITAMIN D DEFICIENCY; WATER-ELECTROLYTE BALANCE;

EID: 84922481729     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Review

References (88)

1. Finn R, Flapan D, Rotach D Vitamin D: is it the best thing under the sun? [Internet] Medscap 2013. Available from http//www.medscape.com/features/slide-show/vitamin-d [cited 2014, Sep 1]
2. Bilde D. Nonclassic actions of vitamin D. J Clin Endocrinol Meta 200n, 9):2-34.
3. Holick MF. Vitamin D deficiency N Engl J Me 2007,357 26-81
4. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nails et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans N Engl J Me 2011,(36) 199-2000.
5. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D Am J Physio 2 2001.(28):F-28.
6. Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, Kato et al. Duodenal calcium absorption in vitamin D receptor-knockout mice functional and molecular aspects Proc Natl Acad Sci U S 2 2006.(9)1332-9.
7. Panda DK, Miao D, Bolivar I, Li J, Huo R, Hendy G et al. Inactivation of the 25-hydroxyvitamin D lalpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis J Biol Che2 2006;27):1675-66.
8. Quarles L. Role of FGF23 in vitamin D and phosphate metabolism implications in chronic kidney disease Exp Cell Re2 2012,31) 104-8
9. Haddad J, Chyu K. Competitive protein-binding radioassay for 25-hydroxycholecalciferol J Clin Endocrinol Meta 1971,3)99-5
10. Malabanan A, Veronikis I, Holick M. Redefining vitamin D insufficiency Lance 1998,351 80-6
11. Bischoff-Ferrari H a, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nut2 2006,(8) 1-28
12. Hohck MF, Binkley NC, Bischoff-Ferran HA, Gordon CM, Hanley DA, Heaney R et al. Evaluatio, treatment, and prevention of vitamin D deficiency, J Clin Endocrinol Meta2 2011;9):191-30
13. Institute of Medicine. Dietary reference intakes for calcium and vitamin D Natl Acad Pres2 2011
14. Holick M. Vitamin D status measurement, interpretation, and clinical application Ann Epidemio2 2009,1)7-8
15. Lensmeyer G, Poquette M, Wiebe D, Binkley N. The C-3 epimer of 25-hydroxyvitamin D(3) is present in adult serum J Clin Endocrinol Meta2 201n, 9) 16-8
16. Singh RJ, Taylor RL, Reddy GS, Grebe SKG. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status J Clin Endocrinol Meta2 200g, 9) 305-61
17. Jeng L, Yamshchikov A V, Judd SE, Blumberg HM, Martin GS, Ziegler T et al. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transi Me2 200n;7 28
18. Heijboer AC, Blankenstein M a, Kema IP, Buijs MM. Accuracy of 6 routine 25-hydroxyvitamin D assays influence of vitamin D binding protein concentration Clin Che2 201r, 5):54-8.
19. Krishnan A, Venkatesh B. Vitamin D measurement in the intensive care unit methodology, clinical relevance and interpretation of a random value Inflamm Allergy Drug Target2 2013;(1).23-8.
20. Genzen JR, Gossehn JT, Wilson TC, Racila E, Krasowski MD. Analysis of vitamin D status at two academic medical centers and a national reference laboratory result patterns vary by age, gender, season, and patient location BMC Endocr Disord BMC Endocrine Disorder, 201n, 1) 52
21. Amrein K, Zajic P, Schnedl C, Waltensdorfer A, Fruhwald S, Holl et al. Vitamin D status and its association with season, hospital and sepsis mortality in critical illness. Crit Car2 2014;1) R47
22. Sauneuf B, Brunet J, Lucidarme O, du Cheyron D. Prevalence and risk factors of vitamin D deficiency in critically ill patients Inflamm Allergy Drug Target2 201g, 1):22-9.
23. Quraishi SA, Camargo CA. Vitamin D in acute stress and critical illness. Curr Opin Clin Nutr22012,33:66-5
24. Krishnan A, Ochola J, Mundy J, Jones M. Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients Crit Care 2010;14:R216
25. Waldron JL, Ashby HL, Cornes MP, Bechervaise J, Razavi C, Thomas O et al. Vitamin D. a negative acute phase reactant. J Clin Patho2 2011,6):62-2
26. Ghashut Ra, Talwar D, Kinsella J, Duncan A, McMillan DC. The effect of the systemic inflammatory response on plasma vitamin 25 (OH) D concentrations adjusted for albumin PLoS On2 201n.) e92614
27. ∗. Crit Care Me2 201n, 4) 136-71
28. Muhairi SJ, Mehairi AE, Khouri A a, Naqbi MM, Maskari F a, Kaabi et al. Vitamin D deficiency among healthy adolescents in Al Ain, United Arab Emirates BMC Public Healt2 2014,(1) 33
29. Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde et al. Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis Osteoporos In2 200n, 2) 13-40
30. Lee P, Eisman J a, Center JR. Vitamin D deficiency in critically ill patients N Engl J Me2 2000;36H91-4
31. Lucidarme O, Messai E, Mazzoni T, Arcade M, du Cheyron D. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Me2 201p;3) 160-11.
32. Wabitsch M, Koletzko B, Mois a Erratum zu Vitamin-D-Versorgung im Sauglings-, Kindes- und Jugendalter. Monatsschrift Kinderheilk2 2010,15) 1084
33. Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents Pediatric2 200v, 12) 114-52
34. Godel JC, Society CP. Vitamin D supplementation-Recommendations for Canadian mothers and infants Paediatr Child Healt2 200p, 1):58-98
35. Rippel C, South M, Butt WW, Shekerdemian LS. Vitamin D status in critically ill children. Intensive Care Me2 201c, 3).205-62.
36. Ayulo Jr M, Katyal C, Agarwal C, Sweberg T, Rastogi D, Markowitz et al. The prevalence of vitamin D deficiency and its relationship with disease severity in an urban pediatric critical care unit Endocr Regu2 2014;4):6-76.
37. Rey C, Sánchez-Arango D, López-Herce J, Martínez-Camblor P, García-Hernández I, Prieto et al. Vitamin D deficiency at pediatric intensive care admission J Pediatr (Rio J) Sociedade Brasileira de Pediatri; 2014,9) 13-42
38. Braun A, Chang D. Association of low serum 25-hy-droxyvitamin D levels and mortality in the critically ill Crit Car2 2011,3)67-7
39. Braun AB, Gibbons FK, Litonjua A a, Giovannucci E, Christopher KB. Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Me2 201n, 4) 6-72
40. Murray MJ. Vitamin d-do our patients need not just a room with a view, but one with sunshine? Crit Care Me2 201n;4):154-2
41. Venkatram S, Chilimuri S, Adrish M, Salako A, Patel M, Diaz-Fuentes G. Vitamin D deficiency is associated with mortality in the medical intensive care unit Crit Care. BioMed Central Lt; 201n, 1).R292
42. McKinney JD, Bailey B a, Garrett LH, Peiris P, Manning T, Peins AN. Relationship between vitamin D status and ICU outcomes in veterans J Am Med Dir Assoc. Elsevier Lt; 201r;1):20-11.
43. Padhi R, Jagati S, Panda B, Patra S. Vitamin D status in adult critically ill patients in Eastern India: An observational retrospective study Lung Indi2 2014;3) 212.
44. Cecchi A. Bonizzoli M, Douar S, Mangini M, Paladini S, Gazzini et al. Vitamin D deficiency in septic patients at ICU admission is not a mortality predictor Minerva Anestesio2 2011,7):118-9.
45. Arnson Y, Gringauz I, Itzhaky D, Amital H. Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients. QJ2 2011;10):63-9
46. Flynn L, Zimmerman LH, McNorton K, Dolman M, Tyburski J, Baylor et al. Effects of vitamin D deficiency in critically ill surgical patients. Am J Surg. Elsevier Inc, 201r;20):37-82; discussion 382.
47. Aygencel G, Turkoglu M, Tuncel AF, Candir BA, Bildaci YD, Pasaoglu H. Is vitamin d insufficiency associated with mortality of critically ill patients? Crit Care Res Prac2 201n;2013:856747.
48. Nair P, Lee P, Reynolds C, Nguyen ND, Myburgh J, Eisman J et al. Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes in critically ill patients. Intensive Care Me2 201b;(3):26-74.
49. ∗. Crit Care Me2 2011,4) 207-81
50. Madden K, Feldman H a, Smith EM, Gordon CM, Keisling SM, Sullivan R. et al. Vitamin D deficiency in critically ill children Pediatnc2 201p;13):42-8.
51. McNally JD, Menon K, Chakraborty P, Fisher L, Williams K a, Al-Dirbashi O et al. The association of vitamin D status with pediatric critical illness Pediatric2 201p;13):42-36.
52. Kempker J, Han J. Vitamin D and sepsis An emerging relationship. Dermatoendocrino2 2012;) 10-8
53. Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf)2 201r;7) 31-25
54. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrient2 2011;).250-21.
55. Science M, Maguire JL, Russell ML, Smieja M, Walter SD, Loeb M. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Di2 201g;5):39-7.
56. Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nut2 201v, 10) 143-40.
57. Camargo CA, Ganmaa D, Frazier AL, Kirchberg FF, Stuart JJ, Kleinman et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatric2 201p, 13) e56-7
58. Bergman P, Lindh AU, Bjorkhem-Bergman L, Lindh JD. Vitamin D and Respiratory Tract Infections. A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS On2 201n;):e65835.
59. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik S et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (80-2 2004,31) 177-3.
60. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin J Immuno2 2005;17):206-3
61. Campbell GR, Spector S.A. Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1. PLoS Patho2 201n;):e1003017
62. Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, Borregaard et al. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults BMC Res Notes. BMC Research Note, 201n;)575
63. Honda JR, Connick E, MaWhinney S, Chan ED, Flores SC. Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy J Med Microbio2 2014,63 99-1003.
64. Tangpricha V, Judd SE, Ziegler TR, Hao L, Alvarez J, Fitzpatrick A et al. LL-37 Concentrations and the Relationship to Vitamin D, Immune Status, and Inflammation in HIV-infected Children and Young Adults AIDS Res Hum Retroviruse2 20L4;(3):67-6.
65. Barbeiro DF, Barbeiro HV, Zampieri FG, César Machado MC, Torggler Filho F, Gomes Cunha D. et al. Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock. Microbes Infec2 201y;1):34-6.
66. Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immuno2 200r,(3):36-70.
67. Equils O, Naiki Y, Shapiro a M, Michelsen K, Lu D, Adams. et al. 1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immuno2 200n;14)5-64.
68. Khoo A-L, Chai LY a, Koenen HJPM, Kullberg B-J, Joosten I, van der Ven AJ a. et al. 1,25-dihydroxy-vitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses J Infect Di2 2011,20). 12-30
69. Li P, Xu X, Cao E, Yu B, Li W. Fan M et al. Vitamin D Deficiency Causes Defective Resistance to Aspergillus fumigatus in Mice via Aggravated and Sustained Inflammation PLoS One 20l4;9:e99805
70. Moromizato T, Litonjua A a, Braun AB, Gibbons FK, Giovannucci E, Christopher KB. Association of Low Serum 25-Hydroxyvitamin D Levels and Sepsis in the Critically Ill Crit Care Med 2013:1-11
71. Su L-X, Jiang Z-X, Cao L-C, Xiao K, Song J-P, Li H et al. Significance of low serum vitamin D for infection risk, disease severity and mortality in critically ill patients. Chin Med T (Engl) 2013,126 2725-30
72. Barnett N, Zhao Z, Koyama T, Janz DR, Wang C-Y, May AK et al. Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study. Ann Intensive Care. Ann Int Care 2014;4.5
73. Ginde A, Camargo C, Shapiro N. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med 2011;18:551-4.
74. Izadpanah M, Khalili H. Potential benefits of vitamin D supplementation in critically ill patients. Immunotherapy 2013,5:843-53.
75. Schnedl C, Pieber TR, Amrein K. Vitamin D intervention trials in critical illness. Inflamm Allergy Drug Targets 2013;12 282-7.
76. Van den Berghe G, van Roosbroeck D, Vanhove P, Wouters PJ, de Pourcq L, Bouillon R. Bone turnover in prolonged critical illness effect of vitamin D. J Clin Endocrinol Metab 2003,88(July):4623-32.
77. Mata-Granados JM, Vargas-Vasserot J, Ferreiro-Vera C, Luque de Castro MD, Pavón RG, Quesada Gómez JM. Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/ MS method. J Steroid Biochem Mol Biol Elsevier Ltd; 2010 Jul, 121(1-2)452-5
78. Ingels C, Van Cromphaut S, Wouters P, Moller H, Van Herck E, Jans I et al. Effect of restoration of 250HD3 status in prolonged critical illness on serum innate immunity parameters LL-37 and sCD163. Crit Care 2010;14(Suppl 1).P590
79. Amrein K, Sourij H, Wagner G, Holl A, Pieber TR, Smolle KH et al. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Crit Care BioMed Central Ltd 2011;15:R104
80. Amrein K, Schnedl C, Berghold A, Pieber TR, Dobnig H. Correction of vitamin D deficiency in critically ill patients - VLTdAL@ICU study protocol of a double-blind, placebo-controlled randomized clinical trial BMC Endocr Disord BMC Endocrine Disorders 2012;12:27.
81. Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS. Randomized controlled trial of calcitriol in severe sepsis Am J Respir Crit Care Med 2014 Sep 1,190(5)533-41.
82. Jones G. Pharmacokinetics of vitamin D toxicity Am J Clin Nutr 2008;88:582S-586S
83. Amrein K, Quraishi S a, Litonjua A a, Gibbons FK, Pieber TR, Camargo C a et al. Evidence for a U-shaped relationship between prehospital vitamin D status and mortality. a cohort study J Clin Endocrinol Metab 2014,99 1461-9
84. Zittermann A, Kuhn J, Dreier J, Knabbe C, Gummert JF, Borgermann J. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J 2013;34:1358-64
85. Ralph R, Peter JV Chrispal A, Zachariah A, Dian J, Sebastian T et al. Supraphysiological 25-hydroxy vitamin D3 level at admission is associated with illness severity and mortality in critically ill patients J Bone Miner Metab 2014,3-7
86. Vigersky RA. Mad about "U" J Clin Endocrinol Metab 2014;99:771-3
87. Heaney RP. Guidelines for optimizing design and analysis of clinical studies of nutrient effects Nutr Rev 2014;72:48-54
88. The Mayo Medical Laboratories Difference Vitamin D Testing [Internet] 2013 [Internet], Available from: http//www.mayomedicallaboratories.com/articles/vitamind/ [cited 2014, Sep 1].