메뉴 건너뛰기




Volumn 211, Issue 4, 2015, Pages 571-581

Dual impact of live staphylococcus aureus on the osteoclast lineage, leading to increased bone resorption

Author keywords

bone and joint infections; osteoclastogenesis; resorption; Staphylococcus aureus

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUSION; CELL LINEAGE; CONTROLLED STUDY; CYTOKINE RELEASE; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY;

EID: 84922475654     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu386     Document Type: Article
Times cited : (82)

References (45)
  • 1
    • 84869752700 scopus 로고    scopus 로고
    • Osteoblasts, osteoclasts and osteocytes: Unveiling their intimate-associated responses to applied orthodontic forces
    • Lerner U. Osteoblasts, osteoclasts and osteocytes: unveiling their intimate-associated responses to applied orthodontic forces. Sem Orthod 2012; 18:237-48.
    • (2012) Sem Orthod , vol.18 , pp. 237-248
    • Lerner, U.1
  • 2
    • 84865360603 scopus 로고    scopus 로고
    • Bone and joint infections in hospitalized patients in France, 2008: Clinical and economic outcomes
    • Grammatico-Guillon L, Baron S, Gettner S, et al. Bone and joint infections in hospitalized patients in France, 2008: clinical and economic outcomes. J Hosp Infect 2008; 82:40-8.
    • (2008) J Hosp Infect , vol.82 , pp. 40-48
    • Grammatico-Guillon, L.1    Baron, S.2    Gettner, S.3
  • 4
    • 45849148216 scopus 로고    scopus 로고
    • Periprosthetic joint infection: The incidence, timing, and predisposing factors
    • Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res 2008; 466:1710-5.
    • (2008) Clin Orthop Relat Res , vol.466 , pp. 1710-1715
    • Pulido, L.1    Ghanem, E.2    Joshi, A.3    Purtill, J.J.4    Parvizi, J.5
  • 5
    • 0036384321 scopus 로고    scopus 로고
    • Local levels of interleukin-1beta,-4,-6 and tumor necrosis factor alpha in an experimental model of murine osteomyelitis due to staphylococcus aureus
    • Yoshii T, Magara S, Miyai D, et al. Local levels of interleukin-1beta,-4,-6 and tumor necrosis factor alpha in an experimental model of murine osteomyelitis due to staphylococcus aureus. Cytokine 2002; 19:59-65.
    • (2002) Cytokine , vol.19 , pp. 59-65
    • Yoshii, T.1    Magara, S.2    Miyai, D.3
  • 6
    • 73649112355 scopus 로고    scopus 로고
    • Interaction of staphylococci with bone
    • Wright JA, Nair SP. Interaction of staphylococci with bone. Int J Med Microbiol 2010; 300:193-204.
    • (2010) Int J Med Microbiol , vol.300 , pp. 193-204
    • Wright, J.A.1    Nair, S.P.2
  • 7
    • 84877745311 scopus 로고    scopus 로고
    • PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected oste-oblasts
    • Rasigade JP, Trouillet-Assant S, Ferry T, et al. PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected oste-oblasts. PLoS One 2013; 8:e63176.
    • (2013) PLoS One , vol.8 , pp. e63176
    • Rasigade, J.P.1    Trouillet-Assant, S.2    Ferry, T.3
  • 8
    • 77956900585 scopus 로고    scopus 로고
    • Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence
    • Tuchscherr L, Heitmann V, Hussain M, et al. Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence. J Infect Dis 2010; 202:1031-40.
    • (2010) J Infect Dis , vol.202 , pp. 1031-1040
    • Tuchscherr, L.1    Heitmann, V.2    Hussain, M.3
  • 9
    • 0035055294 scopus 로고    scopus 로고
    • Staphylococcus aureus fibronectin binding proteins are essential for in-ternalization by osteoblasts but do not account for differences in intra-cellular levels of bacteria
    • Ahmed S, Meghji S, Williams RJ, Henderson B, Brock JH, Nair SP. Staphylococcus aureus fibronectin binding proteins are essential for in-ternalization by osteoblasts but do not account for differences in intra-cellular levels of bacteria. Infect Immun 2001; 69:2872-7.
    • (2001) Infect Immun , vol.69 , pp. 2872-2877
    • Ahmed, S.1    Meghji, S.2    Williams, R.J.3    Henderson, B.4    Brock, J.H.5    Nair, S.P.6
  • 10
    • 9444241592 scopus 로고    scopus 로고
    • Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin al-pha5beta1
    • Sinha B, Francois PP, Nusse O, et al. Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin al-pha5beta1. Cell Microbiol 1999; 1:101-17.
    • (1999) Cell Microbiol , vol.1 , pp. 101-117
    • Sinha, B.1    Francois, P.P.2    Nusse, O.3
  • 11
    • 84871674150 scopus 로고    scopus 로고
    • Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection
    • Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien FJ, Kerrigan SW. Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin-6 in bone infection. Microbiology 2013; 159: 147-54.
    • (2013) Microbiology , vol.159 , pp. 147-154
    • Claro, T.1    Widaa, A.2    McDonnell, C.3    Foster, T.J.4    O'Brien, F.J.5    Kerrigan, S.W.6
  • 12
    • 79954458075 scopus 로고    scopus 로고
    • Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis
    • Claro T, Widaa A, O'Seaghdha M, et al. Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis. PLoS One 2011; 6:e18748.
    • (2011) PLoS One , vol.6 , pp. e18748
    • Claro, T.1    Widaa, A.2    O'Seaghdha, M.3
  • 13
    • 0034607623 scopus 로고    scopus 로고
    • Intracellular Staphylococ-cus aureus induces apoptosis in mouse osteoblasts
    • Tucker KA, Reilly SS, Leslie CS, Hudson MC. Intracellular Staphylococ-cus aureus induces apoptosis in mouse osteoblasts. FEMS Microbiol Lett 2000; 186:151-6.
    • (2000) FEMS Microbiol Lett , vol.186 , pp. 151-156
    • Tucker, K.A.1    Reilly, S.S.2    Leslie, C.S.3    Hudson, M.C.4
  • 14
    • 84878894078 scopus 로고    scopus 로고
    • Staphylococcus aureus bio-films decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro
    • Sanchez CJ Jr, Ward CL, Romano DR, et al. Staphylococcus aureus bio-films decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro. BMC Musculoskelet Disord 2013; 14:187.
    • (2013) BMC Musculoskelet Disord , vol.14 , pp. 187
    • Sanchez, C.J.1    Ward, C.L.2    Romano, D.R.3
  • 15
    • 84879101014 scopus 로고    scopus 로고
    • A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis
    • Cassat JE, Hammer ND, Campbell JP, et al. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host Microbe 2013; 13:759-72.
    • (2013) Cell Host Microbe , vol.13 , pp. 759-772
    • Cassat, J.E.1    Hammer, N.D.2    Campbell, J.P.3
  • 16
    • 77950654521 scopus 로고    scopus 로고
    • New immune connections in osteoclast formation
    • Takayanagi H. New immune connections in osteoclast formation. Ann N Y Acad Sci 2010; 1192:117-23.
    • (2010) Ann N y Acad Sci , vol.1192 , pp. 117-123
    • Takayanagi, H.1
  • 17
    • 79957931329 scopus 로고    scopus 로고
    • The unexpected link between osteoclasts and the immune system
    • Takayanagi H. The unexpected link between osteoclasts and the immune system. Adv Exp Med Biol 2010; 658:61-8.
    • (2010) Adv Exp Med Biol , vol.658 , pp. 61-68
    • Takayanagi, H.1
  • 18
    • 77955475327 scopus 로고    scopus 로고
    • Cross talk between the bone and immune systems: Osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells
    • Li H, Hong S, Qian J, Zheng Y, Yang J, Yi Q. Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood 2010; 116:210-7.
    • (2010) Blood , vol.116 , pp. 210-217
    • Li, H.1    Hong, S.2    Qian, J.3    Zheng, Y.4    Yang, J.5    Yi, Q.6
  • 19
    • 10244259169 scopus 로고    scopus 로고
    • Immature dendritic cell trans-differentiation into osteoclasts: A novel pathway sustained by the rheumatoid arthritis microenvironment
    • Rivollier A, Mazzorana M, Tebib J, et al. Immature dendritic cell trans-differentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment. Blood 2004; 104:4029-37.
    • (2004) Blood , vol.104 , pp. 4029-4037
    • Rivollier, A.1    Mazzorana, M.2    Tebib, J.3
  • 20
    • 58149398636 scopus 로고    scopus 로고
    • Bone marrow microenviron-ment controls the in vivo differentiation of murine dendritic cells into osteoclasts
    • Wakkach A, Mansour A, Dacquin R, et al. Bone marrow microenviron-ment controls the in vivo differentiation of murine dendritic cells into osteoclasts. Blood 2008; 112:5074-83.
    • (2008) Blood , vol.112 , pp. 5074-5083
    • Wakkach, A.1    Mansour, A.2    Dacquin, R.3
  • 21
    • 84886863244 scopus 로고    scopus 로고
    • Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation
    • Kim J, Yang J, Park OJ, et al. Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation. J Bone Miner Res 2013; 28:2381-91.
    • (2013) J Bone Miner Res , vol.28 , pp. 2381-2391
    • Kim, J.1    Yang, J.2    Park, O.J.3
  • 22
    • 81355142848 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus
    • Pietrocola G, Arciola CR, Rindi S, et al. Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus. Int J Artif Organs 2011; 34:799-810.
    • (2011) Int J Artif Organs , vol.34 , pp. 799-810
    • Pietrocola, G.1    Arciola, C.R.2    Rindi, S.3
  • 23
    • 0036681842 scopus 로고    scopus 로고
    • Stimulation by toll-like receptors inhibits osteoclast differentiation
    • Takami M, Kim N, Rho J, Choi Y. Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol 2002; 169:1516-23.
    • (2002) J Immunol , vol.169 , pp. 1516-1523
    • Takami, M.1    Kim, N.2    Rho, J.3    Choi, Y.4
  • 24
    • 70349643035 scopus 로고    scopus 로고
    • Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88
    • Yang J, Ryu YH, Yun CH, Han SH. Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88. J Leukoc Biol 2009; 86:823-31.
    • (2009) J Leukoc Biol , vol.86 , pp. 823-831
    • Yang, J.1    Ryu, Y.H.2    Yun, C.H.3    Han, S.H.4
  • 25
    • 0028859357 scopus 로고
    • Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes
    • Greene C, McDevitt D, Francois P, Vaudaux PE, Lew DP, Foster TJ. Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes. Mol Microbiol 1995; 17:1143-52.
    • (1995) Mol Microbiol , vol.17 , pp. 1143-1152
    • Greene, C.1    McDevitt, D.2    Francois, P.3    Vaudaux, P.E.4    Lew, D.P.5    Foster, T.J.6
  • 27
    • 79959713600 scopus 로고    scopus 로고
    • A novel flow cytometry-based assay for the quantification of Staphylococcus aureus adhesion to and invasion of eukaryotic cells
    • Trouillet S, Rasigade JP, Lhoste Y, et al. A novel flow cytometry-based assay for the quantification of Staphylococcus aureus adhesion to and invasion of eukaryotic cells. J Microbiol Methods 2011; 86: 145-9.
    • (2011) J Microbiol Methods , vol.86 , pp. 145-149
    • Trouillet, S.1    Rasigade, J.P.2    Lhoste, Y.3
  • 28
    • 77955491869 scopus 로고    scopus 로고
    • The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate
    • James DE, Nestor BJ, Sculco TP, et al. The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate. J Immunol 2010; 185:1265-73.
    • (2010) J Immunol , vol.185 , pp. 1265-1273
    • James, D.E.1    Nestor, B.J.2    Sculco, T.P.3
  • 29
    • 84862924311 scopus 로고    scopus 로고
    • Platinum nanoparticles suppress osteoclastogenesis through scavenging of reactive oxygen species produced in RAW264.7 cells
    • Nomura M, Yoshimura Y, Kikuiri T, et al. Platinum nanoparticles suppress osteoclastogenesis through scavenging of reactive oxygen species produced in RAW264.7 cells. J Pharmacol Sci 2011; 117:243-52.
    • (2011) J Pharmacol Sci , vol.117 , pp. 243-252
    • Nomura, M.1    Yoshimura, Y.2    Kikuiri, T.3
  • 30
    • 0035151975 scopus 로고    scopus 로고
    • Ultrastructural evidence in vitro of osteoclast-induced degradation of calcium phosphate ceramic by simultaneous resorption and phagocytosis mechanisms
    • Heymann D, Guicheux J, Rousselle AV. Ultrastructural evidence in vitro of osteoclast-induced degradation of calcium phosphate ceramic by simultaneous resorption and phagocytosis mechanisms. Histol Histo-pathol 2001; 16:37-44.
    • (2001) Histol Histo-pathol , vol.16 , pp. 37-44
    • Heymann, D.1    Guicheux, J.2    Rousselle, A.V.3
  • 31
    • 84873828600 scopus 로고    scopus 로고
    • Osteoclast migration, differentiation and function: Novel therapeutic targets for rheumatic diseases
    • Kikuta J, Ishii M. Osteoclast migration, differentiation and function: novel therapeutic targets for rheumatic diseases. Rheumatology (Oxford) 2013; 52:226-34.
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 226-234
    • Kikuta, J.1    Ishii, M.2
  • 32
    • 18144393375 scopus 로고    scopus 로고
    • MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation
    • Kim MS, Day CJ, Morrison NA. MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. J Biol Chem 2005; 280:16163-9.
    • (2005) J Biol Chem , vol.280 , pp. 16163-16169
    • Kim, M.S.1    Day, C.J.2    Morrison, N.A.3
  • 33
    • 33144460421 scopus 로고    scopus 로고
    • Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human oste-oclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES
    • Kim MS, Magno CL, Day CJ, Morrison NA. Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human oste-oclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES. J Cell Biochem 2006; 97:512-8.
    • (2006) J Cell Biochem , vol.97 , pp. 512-518
    • Kim, M.S.1    Magno, C.L.2    Day, C.J.3    Morrison, N.A.4
  • 34
    • 34248545487 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption
    • Lu Y, Cai Z, Xiao G, et al. Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption. Cancer Res 2007; 67:3646-53.
    • (2007) Cancer Res , vol.67 , pp. 3646-3653
    • Lu, Y.1    Cai, Z.2    Xiao, G.3
  • 35
    • 67349232758 scopus 로고    scopus 로고
    • MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner
    • Miyamoto K, Ninomiya K, Sonoda KH, et al. MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner. Biochem Biophys Res Commun 2009; 383:373-7.
    • (2009) Biochem Biophys Res Commun , vol.383 , pp. 373-377
    • Miyamoto, K.1    Ninomiya, K.2    Sonoda, K.H.3
  • 36
    • 0033608227 scopus 로고    scopus 로고
    • Macrophage-inflammatory protein-1alpha regulates preosteoclast differentiation in vitro
    • Scheven BA, Milne JS, Hunter I, Robins SP. Macrophage-inflammatory protein-1alpha regulates preosteoclast differentiation in vitro. Biochem Biophys Res Commun 1999; 254:773-8.
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 773-778
    • Scheven, B.A.1    Milne, J.S.2    Hunter, I.3    Robins, S.P.4
  • 37
    • 9344269652 scopus 로고    scopus 로고
    • CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts
    • Yu X, Huang Y, Collin-Osdoby P, Osdoby P. CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts. J Bone Miner Res 2004; 19:2065-77.
    • (2004) J Bone Miner Res , vol.19 , pp. 2065-2077
    • Yu, X.1    Huang, Y.2    Collin-Osdoby, P.3    Osdoby, P.4
  • 38
    • 0036231873 scopus 로고    scopus 로고
    • Transcriptional activity of nuclei in multinucleated osteoclasts and its modulation by calcitonin
    • Boissy P, Saltel F, Bouniol C, Jurdic P, Machuca-Gayet I. Transcriptional activity of nuclei in multinucleated osteoclasts and its modulation by calcitonin. Endocrinology 2002; 143:1913-21.
    • (2002) Endocrinology , vol.143 , pp. 1913-1921
    • Boissy, P.1    Saltel, F.2    Bouniol, C.3    Jurdic, P.4    Machuca-Gayet, I.5
  • 39
    • 0035128622 scopus 로고    scopus 로고
    • Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films
    • Lees RL, Sabharwal VK, Heersche JN. Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films. Bone 2001; 28:187-94.
    • (2001) Bone , vol.28 , pp. 187-194
    • Lees, R.L.1    Sabharwal, V.K.2    Heersche, J.N.3
  • 40
    • 0026728085 scopus 로고
    • The relationship between the number of nuclei of an osteoclast and its resorptive capability in vitro
    • Piper K, Boyde A, Jones SJ. The relationship between the number of nuclei of an osteoclast and its resorptive capability in vitro. Anat Embryol (Berl) 1992; 186:291-9.
    • (1992) Anat Embryol (Berl) , vol.186 , pp. 291-299
    • Piper, K.1    Boyde, A.2    Jones, S.J.3
  • 41
    • 34247468008 scopus 로고    scopus 로고
    • Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases
    • Trebec DP, Chandra D, Gramoun A, Li K, Heersche JN, Manolson MF. Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases. J Cell Biochem 2007; 101:205-20.
    • (2007) J Cell Biochem , vol.101 , pp. 205-220
    • Trebec, D.P.1    Chandra, D.2    Gramoun, A.3    Li, K.4    Heersche, J.N.5    Manolson, M.F.6
  • 42
    • 55849107728 scopus 로고    scopus 로고
    • Staphylo-coccus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts
    • Somayaji SN, Ritchie S, Sahraei M, Marriott I, Hudson MC. Staphylo-coccus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts. Infect Immun 2008; 76:5120-6.
    • (2008) Infect Immun , vol.76 , pp. 5120-5126
    • Somayaji, S.N.1    Ritchie, S.2    Sahraei, M.3    Marriott, I.4    Hudson, M.C.5
  • 43
    • 84891721706 scopus 로고    scopus 로고
    • A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts
    • Clarke MS, Sundaresan A, Vanderburg CR, Banigan MG, Pellis NR. A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts. Acta Biomater 2013; 9:7908-16.
    • (2013) Acta Biomater , vol.9 , pp. 7908-7916
    • Clarke, M.S.1    Sundaresan, A.2    Vanderburg, C.R.3    Banigan, M.G.4    Pellis, N.R.5
  • 44
    • 77955843622 scopus 로고    scopus 로고
    • Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice
    • Kasahara T, Imai S, Kojima H, et al. Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice. Bone 2010; 47:617-25.
    • (2010) Bone , vol.47 , pp. 617-625
    • Kasahara, T.1    Imai, S.2    Kojima, H.3
  • 45
    • 84910017093 scopus 로고    scopus 로고
    • Intravital multiphoton microscopy for dissecting cellular dynamics in arthritic inflammation and bone destruction
    • Kikuta J, Ishii M. Intravital multiphoton microscopy for dissecting cellular dynamics in arthritic inflammation and bone destruction. Methods Mol Biol 2014; 1142:1-10.
    • (2014) Methods Mol Biol , vol.1142 , pp. 1-10
    • Kikuta, J.1    Ishii, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.